Sentences with phrase «targeted biological therapy»
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Biological markers could enable tailored therapies that target individual differences in symptoms
https://www.scientificamerican.com/
«Our results suggest that we've been looking at these cancer drugs the wrong way — as tumour - targeting drugs — instead of what we now feel is their most important biological role: as immune stimulating therapy.»
«Our study reveals a new mechanism that could be harnessed for biological therapies for lupus and other autoimmune diseases, where the immune system mistakenly targets the body's own cells,» says senior study author Boris Reizis, PhD, professor of Pathology and Medicine at NYU Langone.
Mining that data is critical to developing therapies that target key points in relevant biological pathways — and represents opportunities for bioinformatics experts, Chung says.
«Alcohol prevents ability to extinguish fearful memories in mice: Insight into cellular mechanisms illuminates biological target for PTSD therapy.»
In future, Bandyopadhyay says, better understanding how chemotherapy agents impact specific biological pathways should allow drug trials to focus on patients who are more likely to respond to the drugs being tested and enable clinicians to identify targeted or combination therapies for patients with a genetic predisposition to resistance.
The new method gives scientists more power not only to find new antibody - based therapies, but also to discover the biological pathways through which they work — pathways that may turn out to be more easily and cheaply targeted by small - molecule drugs.
Professor Sterk commented: «We are living in an era where we have new biological knowledge and new targets for therapy but we largely continue to guide patient management with diagnostic labels.
Their findings could help to improve breast cancer prevention by targeting these specific biological mechanisms with cancer therapies in at risk patients and potentially lead the way for a new strategy for the use of preventative treatments.
Where research uncovers possible mechanisms for disease, those working in drug discovery can use these data to develop novel diagnostic or monitoring tools, to develop therapies that address the biological pathways concerned, or to develop companion diagnostics to ensure that new — or existing — therapies are targeted at the correct subgroup of patients.
LA JOLLA — Scientists at the Salk Institute for Biological Studies have identified a key genetic switch linked to the development, progression and outcome of cancer, a finding that may lead to new targets for cancer therapies.
The ultimate goal is to increase the number of new diagnostics and therapies for patients while reducing the time and cost of developing them, by jointly identifying and validating promising biological targets for several diseases, including type 2 diabetes.
Researchers continue to decode the mysteries of hematologic malignancies, and the most successful therapies target the genetic or biological abnormality that is spurring the growth of cancer cells.
Given the tailored inhibition of selected genes and the added precision brought by targeted delivery systems, RNAi - based therapies are thought to carry lower risk of failure than traditional approaches as the biological effects are more predictable.
Researches the biological pathways associated with human eye disease to decipher disease mechanisms and find therapy targets.
«Preliminary optical coherence tomography [OCT] results from the REVERSE trial indicate that the biological targets of the mitochondrial DNA gene therapy have been successfully engaged in the treated eye compared to the untreated eye.
We now currently have enough information about genetic factors that contribute to glaucoma that we really can begin to identify biological processes and proteins that contribute to the disease, making it possible to develop novel therapies that actually target those processes and proteins.
However, a general heterogeneity of biological properties (including the expression of specific receptors and their ability to support endocytosis) often reduces the selectivity of NP targeting and the precision of the following diagnosis and therapy [21,41 - 43].