Additionally, there were greater activity in
the targeted brain region in participants who took fructose, meaning they had heightened desire to eat.
Drugs taken orally, he says, can not
target brain regions with the specificity that a CEO might wish.
Further, transcranial magnetic stimulation isn't a precise tool for
targeting brain regions.
What's more, the same mechanisms are likely at play in one of the most common forms of epilepsy, called temporal lobe epilepsy (TLE), which
targets brain regions responsible for learning and memory.
Cells in
the targeted brain regions fired when researchers asked subjects about their own views; they would also activate if such questions were followed by queries about the character with whom the volunteer most identified.
This theoretical consistency is important, as it allows researchers to better focus future studies of brain connectivity in schizophrenia, by
targeting the brain regions known to be affected.
He injected two colors of beads — magenta and green — into two different
target brain regions.
Not exact matches
Spurred on by the finding, Johnson and Wemmie conducted an extensive search of the scientific literature on bipolar disorder and began to find pieces of evidence that suggested that the cerebellum may function abnormally in bipolar disorder and that lithium might potentially
target the cerebellum and alter glucose levels in this
brain region.
WHITE MAGIC
Targeting parts of the
brain's white matter, the tissue that connects different
brain regions (shown), may be key to whether stimulating the
brain with electricity will work as a treatment for memory problems and other ills.
The researchers
targeted inhibitory neurons in the visual cortex to turn them «on,» thus silencing that
region of the
brain.
And customizing the feedback fMRI is generally more difficult than customizing the dose of a drug, because each person might be helped best by
targeting a different
brain region with a different mental exercise.
Much of the research so far has
targeted single
regions of the
brain, yet it is possible that multiple
regions are involved.
Psychoactive drugs,
targeting general
brain regions and cell types, were too broad as well.
In humans, this
region could be a
target for bringing some
brain injury patients out of a comatose state via electrical stimulation, says lead author Nigel Pedersen, MD, assistant professor of neurology at Emory University School of Medicine and an epilepsy specialist at Emory Brain Health Ce
brain injury patients out of a comatose state via electrical stimulation, says lead author Nigel Pedersen, MD, assistant professor of neurology at Emory University School of Medicine and an epilepsy specialist at Emory
Brain Health Ce
Brain Health Center.
His work suggests that deep -
brain stimulation — whether electrical or optical — may be most effective when it
targets not the neurons themselves but the connections between cells, thereby affecting the flow of activity between
brain regions.
They have developed a new, non-invasive method for modulating deep sleep in humans in a
targeted region of the
brain.
By tracing the wiring that connects one
brain region to the next, researchers hope to develop more precisely
targeted medications.
«This study illustrates the potential of gaining fundamental insights into
brain function while helping patients with debilitating diseases, and provides us with a powerful way of selecting
targets based on their connectivity to other
regions that can be widely applied to help guide
brain stimulation therapy across multiple neurological and psychiatric disorders.»
The pilot study found that DBS
targeting frontal
brain regions can reduce the overall performance decline typically seen in people with mild or early stage Alzheimer's, Scharre said.
The finding, published in Nature, could pave the way for these so - called intercalated cells in the amygdala, a
brain region that processes fear, to become drug
targets for treating phobias (such as fear of heights and closed spaces) as well as post-traumatic stress disorder in soldiers and others.
«A better understanding of the
brain region and cell type - specific binding
targets of Hnrnph1 will tell us more about the function of this gene and possibly identify new therapeutic strategies for minimizing risk and treating psychostimulant addiction — a disorder for which there is currently no FDA - approved drug,» explained corresponding author Camron Bryant, PhD, assistant professor of Pharmacology and Experimental Therapeutics & Psychiatry at BUSM.
The solution was
targeted to each animal's striatum, a
brain region involved in motor control; it is the dopamine - producing nerve cells in this area that die during Parkinson's disease.
We therefore hypothesized that theta - burst microstimulation,
targeted to
brain regions containing afferent fibers to the hippocampus, would improve episodic memory performance in humans.
The results of the study reveal that transcranial direct current stimulation designed to simultaneously
target motor and cognitive
regions apparently induces immediate aftereffects in the
brain that translate into reduced freezing of gait and improvements in executive function and mobility.»
They show that a gradient of Wnt3 along the medial - lateral axis within the developing
brain is the opposing regulating force — working along with ephrinB1 to specify the topographic
target selection in the optic tectum, a
brain region that processes information from the eye.
As previously noted, these animals accumulate CTTAS in vulnerable
brain regions in a pattern consistent with that observed in humans suffering with diagnosed PD and LBD, [16] making them a good model for testing mAbs intended to
target these species.
The system, originally developed in 2007 and refined by Wall and Callaway for
targeting specific cell types in 2010, uses a modified version of the rabies virus to «infect» a
brain region, which in turn
targets neurons that are connected to it.
FlyMAD, or Fly Mind Altering Device, with its inbuilt video tracking system allows the researchers to
target light or to heat specific body
regions within the fly's body even while the insect is in motion and to simultaneously analyse
brain cell activity.
One might speculate that each of these damage - repair therapeutics may exhibit differential
targeting of particular AS species or
brain regions, as different clinical synucleinopathies exhibit distinct regional localizations and conformations of AS pathology.
A selected set of
targets have been analyzed by using the antibodies in serial sections of mouse
brain which covers 129 areas and subfields of the
brain, several of these
regions difficult to cover in the human
brain.
Such complexity is reflected by the involvement of various
brain regions and multiple pathways in the etiology of neurodegenerative diseases that render single drug
target approaches ineffective.
These network maps are essential in pinpointing key
regions in the
brain that are affected in neurological disorders, and thus may be viable
targets for treatment.
«Several studies have
targeted the thalamus with deep
brain stimulation to treat Parkinson's, but the
region's role in the disease was not well established,» adds Dr. Kreitzer, who is also an associate professor of physiology and neurology at UCSF.
Importantly, NSCs can
target breast cancer metastasis in the
brain [9] and can penetrate deep and hypoxic
regions of solid tumors [7].
Not only is this a novel way to study basic biological mechanisms of these commonly
targeted receptors inside the
brain and individual neurons, but it's also a tool scientists can use to study specific effects of drugs in various
regions of the
brain.
Also, if an ACC marker predicts better response, researchers might develop cognitive training that specifically
targets this
region, which could increase
brain activation to accelerate or boost response to more traditional intervention.
Such
targeting might be enabled by the ability to monitor changes in
brain activation within localized
brain regions in real time.