Sentences with phrase «targeted by an autoimmune disease»

Almost all organs and tissues can be targeted by an autoimmune disease.

Not exact matches

Although that marker, called IL21, had not previously been associated with autoimmune diseases, the gene that produces it sits right in the stretch of DNA known to make these mice vulnerable to diabetes, suggesting that IL21 might make a drug target, says Sarvetnick.Furthermore, by giving the animals a shot of dead bacteria — similar to an immunization in humans — when they were newborns, Sarvetnick and her colleagues prevented a surfeit of CD4 + and CD8 + cells.

He notes that in many autoimmune diseases, the immune system targets many proteins, not just the initial one mimicked by a virus.

The Penn researchers demonstrated their new technique by successfully treating an otherwise fatal autoimmune disease in a mouse model, without apparent off - target effects, which could harm healthy tissue.

Scientists were able to selectively target the cells that cause autoimmune disease by dampening down their aggression against the body's own tissues while converting them into cells capable of protecting against disease.

Patients with PNDs carry antibodies that specifically target these proteins, but identifying the target antigens — intracellular proteins — challenged the dogma that the antibodies mediate disease by causing an autoimmune attack on brain tissue.

These syndromes include conditions in which autoimmunity is clearly implicated as causal, in light of identification of autoantibodies to relevant autoantigens; diseases suspected to be autoimmune because of the presence of autoantibodies, although the autoreactive response has not been proven to be pathogenic and could be a consequence or marker of tissue damage; and other diseases often considered to be «autoimmune,» such as psoriasis or inflammatory bowel disease, characterized by organ - targeted inflammation but without evidence of a stimulating autoantigen.