Sentences with phrase «targeted by drug»

WHAT: When his estranged teenage daughter (Emily Moriarty) is targeted by a drug cartel, ex-convict John Link (Mel Gibson) must protect her by any means necessary.

For example, perhaps the amino acid interactions that stabilize the pump structure could be targeted by drug development efforts to block pump assembly or function, thereby rendering currently defunct antibiotics effective once more.

«The number of protein functions that are currently targeted by drugs is incredibly small compared to the total number of protein interactions that could be targeted for therapeutic benefit,» says Geoffrey Wahl, a professor in Salk's Gene Expression Laboratory.

The results suggested that Tye had located an anxiety circuit in the brain that could someday be targeted by drugs.

This work identifies novel steps in disease progression that could potentially be targeted by drugs to halt cognitive decline.

Overall, the research bolstered the case that the PKal pathway can be targeted by drugs independently of the VEGF pathway.

Together, deCODE and Merck are working to identify novel mechanisms to be targeted by drugs for the treatment of obesity.

For example, carbohydrates and foods that contain vitamin D boost levels of serotonin, a neurotransmitter associated with mood (and the same one targeted by drugs such as Prozac).

Decreasing soluble epoxide hydrolase has become a target by drug companies, in order to produce medication in order to reduce hypertension, inflammation and tobacco - induced lung inflammation.

«We know that the dopamine system, which is targeted by drugs of abuse, is also very interested in unpredictable rewards.

Not exact matches

The drug targets a wider variety of defence mechanisms used by antibiotic - resistant bacteria and can be used in more situations.

There are actually a few of those drugs now: Cervarix, made by GSK, which targets strains 16 and 18; Gardasil, made by Merck, which preempts those two killers, plus strains 6 and 11; and Merck's Gardasil 9, which primes the body's immune system to create protective antibodies against — you guessed it — nine types of HPV.

One approach used by Cubist is to target the enzymes produced by drug - resistant bacteria that degrade antibiotic agents and render them useless.

In a new study based on mice, scientists at Lancaster University found that a drug that goes after three diabetes - related targets «significantly reversed the memory deficit» in mice who got the drug, as measured by their performance in a maze test when compared to mice who didn't get the drug.

As the executive branch decides how to address the opioid epidemic, communities hit hardest by the prescription drug crisis are beginning to target the pharmaceutical companies responsible for selling the addictive drugs.

As the Alzheimer's Association notes, until recently, «clinical trials were conducted where up to 30 % of participants did not have the Alzheimer's disease - related brain change targeted by the experimental drug.»

Among the businesses targeted by Davis and five co-defendants were a gas station, a Walgreens drug store and a Wendy's restaurant.

Phase I funding — which allows up to $ 250,000 for an academic idea, such as decoding the genetic sequence of a protein or studying targeted drug delivery by using magnetic nanoparticles — is available from federal funding and foundations.

The 32 - year - old CEO of Turing Pharmaceuticals became a target of widespread ire in September when he boosted the price of the toxoplasmosis treatment Daraprim by over 5,000 % after acquiring the drug in August.

He opened his whirlwind speech by touting his administration's new tariffs — 25 % on steel imports and 10 % on aluminum imports — before wading into the issues surrounding North Korea, previewing his 2020 campaign slogan, discussing the merits of giving drug dealers the death penalty and attacking a series of familiar targets.

To combat the activities of Mexican, Central American, and South American transnational criminal organizations — including illicit finance and money laundering activities and the flow of illegal drugs — the FBI works side - by - side with its numerous domestic and international partners to infiltrate, disrupt, and dismantle these groups by targeting their leadership and using sensitive investigative and intelligence techniques in long - term, proactive investigations.

We need to design clinical trials and outcomes in a way that captures the downsides of aging in a quantitative way» that allows targets for drug approvals by the FDA.

Alnylam, which has been weighed down in the past by drug safety concerns, said it plans to initiate a program targeting cardiomyopathy - another symptom of the disease - alongside polyneuropathy in a late - stage study next year.

(Reuters)- Alnylam Pharmaceuticals Inc's RNAi - based drug that targets a rare genetic disease met the main goal of a key study, in a breakthrough for the new class of medicines that works by blocking disease - causing proteins.

Ought we to be surprised that black youths isolated from the labor market, marginalized by decrepit urban schools, devalued by alienating ideals of beauty and targeted by an unprecedented drug invasion exhibit high rates of crime and teen - age pregnancy?

Consistent with the Hoover Report's recommendations that the United States had to reconsider «long - standing American concepts of fair play» and «learn to subvert, sabotage and destroy our enemies,» the shadow government built alliances between U.S. government officials, the Mafia, and international drug cartels; assassinated many thousands of civilians in Southeast Asia; carried out or attempted assassination of foreign leaders; trained death squads and secret police forces; worked to shore up unpopular dictators like the Shah of Iran and the Somoza dictatorship in prerevolutionary Nicaragua; worked to destabilize «unfriendly» governments such as Allende in Chile and the Sandinistas in Nicaragua; cooperated with the Colombian drug cartel to plot the assassination of the former U.S. ambassador to Costa Rica, Lewis Tambs, with the intention of justifying a U.S. invasion of Nicaragua by blaming his death on the Sandinistas; contracted with the Reagan administration and the National Security Council to find ways of circumventing a congressional ban prohibiting aid to the contras, including the trading of arms to Iran in exchange for hostages and money for the contras; illegally shipped weapons from the United States to the contras and allowed returning planes to use the same protected flight paths to transport drugs into the United States; 11 targeted the U.S. people for disinformation campaigns; and helped prepare contingency plans for declaring a form of martial law in the United States that would have formally suspended constitutional freedoms.

The Grocery Manufacturers Association issued the following statement by Leon Bruner, Chief Science Officer, on the draft sodium reduction guidelines and food category targets released today by the U.S. Food and Drug Administration (FDA).

In June 2016, the Food and Drug Administration (FDA) announced draft voluntary sodium reduction targets, which were partly informed by the design of the National Salt Reduction Initiative.

She had years of knowledge and experience on the subject, and she had needed it all, especially with Alex. Her latest problem child had been questioned more than once about a string of rapes in New York City, a brutal series of crimes where the perpetrator gained the confidence of his targets — and intimidated them — by claiming he was a middleweight contender, then employed drugs to subdue his victims and had his way.

At about the same time two Las Vegas policemen stopped by the gym and told Tocco that Liston had recently turned up at a house that would be the target of a drug raid.

They conclude that risk reduction messages to prevent sudden infant deaths should be targeted more appropriately to unsafe infant care practices such as sleeping on sofas, bed - sharing after the use of alcohol or drugs, or bed - sharing by parents who smoke, and that advice on whether bed - sharing should be discouraged needs to take into account the important relationship with breastfeeding.

Many steps in this misfired immune response are targeted by specific treatments such as systemic and biologic drugs.

Rocky targeted not only dealers by mere USERS of drugs.

The Strike Force was formed to tackle drugs, guns and gangs in the city's high - crime neighborhoods but came under fire for its tactics and was criticized by some who claim it unfairly targeted minorities.

This program is designed to target and shut down known drug markets by establishing programs through which police can collaborate with both prosecutors and the general public.

He said the illegal drug industry begins targeting middle schoolers, so they become addicted by the time they're out of high school.

«Mathematical models target disease with drugs chosen by your DNA.»

Associate professor Mary - Ellen Taplin, of the Dana - Farber Cancer Institute, Boston, USA, will tell the 26th EORTC - NCI - AACR Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, Spain, that galeterone was well tolerated by patients in the ARMOR2 trial, and also lowered PSA levels in a subset of men with CRPC that was resistant to other drugs that target the cancer, such as enzalutamide and abiraterone.

For this study the researchers targeted very specific types of GABA receptors to improve social behaviors with clonazepam, but the team also found that by using a different drug, they could target other GABA receptors and actually reduce the ability to socially interact in normal mice — underscoring that future medications would need to target very specific receptors so as not to diminish the drug's impacts.

Richard Hargreaves, executive director of imaging at Merck Research Laboratories, says, «Nuclear imaging using radiotracers gives the opportunity to put your arms around proof - of - concept very early in a drug discovery and development program by focusing the selection of doses to study on those proven to deliver enough drug to the target therapeutic sites.»

They are working together to mesh her identification of compounds that target tumors with runaway Ras activity and tumor data (analyzed by machine learning) to find patients who could benefit from these potential cancer drugs.

The tumor - cell survival factors uncovered by this study might one day be targeted with drugs to further diminish people's risk of metastasis.

The drug works by targeting a protein carried on the surface of about 90 percent of AML cells.

That suggests that this sodium channel could be a target for the development of drugs to prevent the pain caused by acid build - up — which happens in arthritis and other inflammatory disorders.

Designing molecules that selectively target thiols produced by cancer cells that cause drug resistance is the focus of many years» work by Dimmock, Das and their collaborators.

Researchers at Penn State have combined the two approaches by taking biodegradable polymer nanoparticles encapsulated with cancer - fighting drugs and incorporating them into immune cells to create a smart, targeted system to attack cancers of specific types.

In a study published in the April issue of the Journal of Neuroscience, Saint Louis University scientists led by professor of pharmacological and physiological sciences Daniela Salvemini, Ph.D., discovered that drugs targeting the A3 adenosine receptor can «turn off» pain signals in the spinal cord to provide relief from chronic pain.

By understanding how the body's natural hormones operate, they aim to develop synthetic compounds to target these receptors in order to create drugs to treat diseases.

That means there are two routes by which GPR120 could influence diabetes, which makes it a very nice drug target, he says.

And customizing the feedback fMRI is generally more difficult than customizing the dose of a drug, because each person might be helped best by targeting a different brain region with a different mental exercise.