Sentences with phrase «targeted by the immune system»

The predators had enough time to attack the infection before being targeted by the immune system themselves, creating an ideal treatment window.

Most cells from a foreign donor, such as in transplanted organs, are targeted by the immune system, but «this one has found a way to suppress the immune system of its hosts long enough to let it be passed along,» he says.

But by eliminating the sugar molecule, the new mutation also affects «a key region in the virus that is targeted by the immune system,» Hensley adds, making the vaccine less effective.

Not exact matches

There are actually a few of those drugs now: Cervarix, made by GSK, which targets strains 16 and 18; Gardasil, made by Merck, which preempts those two killers, plus strains 6 and 11; and Merck's Gardasil 9, which primes the body's immune system to create protective antibodies against — you guessed it — nine types of HPV.

Vaccines work by priming the immune system to recognize the target pathogen and attack it when detected.

Although the group didn't identify the toxin's target, it probably causes cells to die from within by overstimulating the immune system, says immunologist Harry Hill of the University of Utah.

Researchers at Penn State have combined the two approaches by taking biodegradable polymer nanoparticles encapsulated with cancer - fighting drugs and incorporating them into immune cells to create a smart, targeted system to attack cancers of specific types.

According to the scientists» findings, targeting c - FLIP with the OH14 compound works on two fronts: first by helping to deactivate the tumour's self - defense mechanism against the immune system and second to prevent its regrowth.

Both tasocitinib and Incyte's drug, INCB028050, target Janus kinases, which mediate signaling by immune - system proteins called cytokines.

MS drugs that target the immune system provide some benefit by reducing relapses, but these drugs can't seem to prevent long - term neurodegeneration, Popko says.

It is triggered by the immune system, and new insights into immune processes have thrown up a number of exciting drug targets.

Joseph Wu of Stanford University, California, and his team have found that a mouse's immune system can be primed to recognise and target cancer cells by vaccinating them beforehand with stem cells.

By manipulating the function of certain immune cells, called T cells, researchers could help restore the system's balance and create new treatments to target these diseases.

Johns Hopkins researchers say they have identified a set of genes that appear to predict which tumors can evade detection by the body's immune system, a step that may enable them to eventually target only the patients most likely to respond best to a new class of treatment.

Yet a virus made so weak that it can not get us sick often can not even last long enough to deliver the gene to its target, being destroyed by the human immune system before it arrives.

As with innate immunity, the adaptive immune system — the T cells and antibodies produced by B cells that target specific molecules on invading cells — contributes to pathology or may also fight against it.

In laboratory studies, daratumumab caused the targeted killing of CD38 - carrying tumor cells by several distinct and potent mechanisms, including some that involve the immune system.

By examining blood plasma of two - year - olds exposed to the disease, researchers have discovered a new vaccine target: a protein recognized by the immune systems of malaria - resistant childreBy examining blood plasma of two - year - olds exposed to the disease, researchers have discovered a new vaccine target: a protein recognized by the immune systems of malaria - resistant childreby the immune systems of malaria - resistant children.

Known as a checkpoint inhibitor, tremelimumab is an investigational monoclonal antibody that «cuts the brakes» of the immune system by targeting cytotoxic T - lymphocyte antigen 4 (CTLA - 4), a protein that can switch off a patient's immune response.

«Mouse study reveals potential drug target for arthritis caused by chikungunya virus: A specific immune system proteinase may promote arthritic inflammation after viral infection.»

He notes that in many autoimmune diseases, the immune system targets many proteins, not just the initial one mimicked by a virus.

Monitoring immune responses by measuring cytokine levels has become an integral part of disease - related research, providing clues to the state of the immune system and how it could be targeted therapeutically.

An international research team headed by the rheumatologist Dr Andreas Ramming at Friedrich - Alexander - Universität Erlangen - Nürnberg (FAU) has now managed to identify an immune system cell type that can be used in a targeted attempt to control the inflammatory response in arthritis patients.

Two types of vaccines were used for the study: one constructed with genetically engineered DNA molecules that teach immune system cells to recognize premalignant cells expressing HPV16 E7 proteins, and one that is a non-infectious, engineered virus that targets and kills precancerous cells marked by HPV16 and HPV18 E6 and E7 proteins.

«By selectively targeting the source of the immune activation rather than shutting off the innate immune system downstream, these nucleic acid scavengers are able to limit pathological inflammation without compromising one's ability to fight a viral infection,» Sullenger said.

The team believed that because these proteins might be exposed on the surface of the membrane, they could conceivably be targeted by the human immune system.

To avoid being targeted by their hosts» immune systems, tumors maintain an immunosuppressive environment by manipulating the characteristics of the immune and vascular system.

CRISPR, originally discovered by biologists studying the bacterial immune system, consists of a DNA - cutting enzyme called Cas9 and short RNA guide strands that target specific sequences of the genome, telling Cas9 where to make its cuts.

Certain molecules on tumors can serve as targets for attack by cells of the immune system.

«This is because the stress led to poor function against the cancer by T - cells, which are very important in the immune system's control and surveillance of tumours and are a major target in many immunotherapy treatments.»

«Brain cancer cells are very good at evading the host immune system, because they do not express specific targets that can be recognized by immune cells,» said Liau, professor and vice chair of neurosurgery.

Thus, the worms avoid being killed by the immune system and they eventually target the human liver,» said Batt.

By targeting CTLA - 4, ipilimumab restimulates the immune system to target tumor cells.

In the last few years, scientists in Southampton have been at the forefront of research into the role of the immune system in Alzheimer's, so it is encouraging to see this study taking these ideas forward by identifying a specific mechanism that could be a target for future treatments.

These treatments work by stimulating the patient's immune system to effectively target and...

epitope - a specific part on the surface of a virus that is targeted for destruction by the body's immune system.

Our industry - leading technology, invented by GigaGen's co-founders, interrogates immune systems with unprecedented depth and breadth — radically accelerating the selection of drug targets, identification of drug candidates and assessment of pre-clinical drug efficacy.

8.30 Hana Paculová CDK12 connects transcriptional regulation to DNA damage repair pathway 8.55 Karol Kaiser Wnt secretion during nervous system development 9.20 Simona Hankeová The role of Notch signaling in vasculogenesis 10.00 Coffee break 10.30 Tomáš Doležal Extracellular adenosine regulates complex host - pathogen interactions through the energy release for the immune response 10.55 Ondřej Bernatík and Igor Červenka Regulation of diverse function of Dvl by phosphorylation 11.20 Jan Ryneš Dissection of Axin interactome: rational approach for control of signaling cascades via intervention with specific protein - protein interactions 12.05 Targeting opportunities: discussion & sum - up 13.00 Lunch and departure

There is already evidence that senescent cells are targeted by the innate immune system.

In the new study, the team's experimental vaccine works by effectively misdirecting the immune system to fight off a more dangerous target than the allergen.

The target of «atezo» is a molecule called PD - L1, which some cancer cells make to try to avoid being killed by the immune system.

Epitopes are specific target structures recognized by the immune system of human or animal body.

By harnessing the immune system to target bladder cancer, researchers have yielded two discrete new treatment agents.

Efficient methods for tumor targeting are eagerly awaited and must satisfy several challenges: molecular specificity, transport through physiologic barriers, and capacity to withstand extracellular or intracellular degradation and inactivation by the immune system.

Sophisticated cell targeting systems such as the gene therapy approach developed for senescent cell clearance by Oisin Biotechnologies could also be turned to stem cell or immune cell destruction, given suitable markers of cell chemistry.

They are highly immunogenic and, therefore, targeted by the adaptive immune system.

• Disease - driving pathways that involve the human immune system are often targeted by antibodies, and Organ - Chips recreate complex interactions of different human cell types and aspects of the human immune system, overcoming limitations of animal models which do not reflect all human immune cells.

Considering the importance of pDCs in the pathogenesis of SSc and other diseases characterized by a type I IFN signature, miR - 618 potentially represents an important epigenetic target to regulate immune system homeostasis in these conditions.

«By bringing our research together, we want to illuminate pathways by which tumor cells and HIV evolve to avoid immune system attacks and use this knowledge to identify new targets for prevention and treatment for both diseases.&raquBy bringing our research together, we want to illuminate pathways by which tumor cells and HIV evolve to avoid immune system attacks and use this knowledge to identify new targets for prevention and treatment for both diseases.&raquby which tumor cells and HIV evolve to avoid immune system attacks and use this knowledge to identify new targets for prevention and treatment for both diseases.»

«The immune system sees the hair as foreign and targets it by mistake.»