Sentences with phrase «targeted epigenetic modification»

To alter DNA modifications, researchers used blunt tools like histone deacetylases, but targeted epigenetic modification was impossible.

Not exact matches

Corin is particularly attractive as an inhibitor of epigenetic modifications because it has dual - target specificity which allows for more selective targeting of epigenetic complexes in treated cells.

So what we think is that probably in many cells in this section, all cells, the chromatin is encountered in a specific state, and in order to render the cell is permissive to reprogramming, you have to overcome these certain epigenetic modifications that block, for example, the binding of Ascl1 to its target chains, or the binding of other transcription factors to its target chains, then this way interfere with the possibility of reprogramming.

If you want to study the effects of one particular modification for which a targeted editor, like H3K27ac, is available, an epigenetic tool would be your best bet.