Sentences with phrase «targeted epigenetic modifiers»

In contrast, epigenetic marks left by targeted epigenetic modifiers may be more frequently inherited by daughter cells.

Not exact matches

In certain cases, epigenetic modifiers may work better than activators / repressors - Hilton et al. found that dCas9 - p300 increased transcriptional activation more than dCas9 - VP64, especially when targeting distal enhancers.

First observed in B - cell lymphoma, recurrent mutations of epigenetic modifier genes have recently been identified in PTCL - NOS. 9 In the present study, we performed targeted sequencing of the main epigenetic modifier genes in a large cohort of Chinese PTCL - NOS patients.

A total of 91 somatic mutations of epigenetic modifier genes were identified in 60 of 125 (48.0 %) patients with PTCL - NOS by targeted sequencing (Figure 1A).

In contrast, many scientists consider that chromatin does not form an independent epigenetic layer of the genome and that chromatin modifiers do not operate independently of a DNA sequence specific targeting mechanism, such as transcription factors.