Sentences with phrase «targeted epigenetic therapies»
The researchers believe there are other disease entities, aside from cancers, that may be significantly affected by targeted epigenetic therapies.
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«These new insights into the complexities of epigenetic regulation are contributing to our basic understanding of this process in human health and disease and gives us new vision for how to go about targeting errors in DNA methylation with innovative drug therapies.»
The current study was designed to clarify the cellular hierarchy underlying glioblastoma, to identify epigenetic factors that distinguish glioblastoma stem cells from more differentiated tumor cells and to suggest potential therapies targeting those factors.
«It is expected that this study will lay the foundation for developing a new class of potent and effective cancer therapies and the development of reagents targeting epigenetic events in immune - mediated diseases as well as other epigenetically - influenced diseases,» said Alani, who also is chief of dermatology at Boston Medical Center.
The proposed strategy reflects a continuing move toward combination therapies, particularly when it comes to epigenetic approaches, which target the mechanisms that control whether genes are switched «on» or «off.»
The researchers were able to reverse these epigenetic changes with the use of an FDA - approved drug, forcing the cancer cells out of hiding and potentially making them better targets for the same immune therapy that in the past may have failed.
«Multiple epigenetic regulators participate in the drug - desensitizing pathway, so they could serve as new targets to improve therapy for this type of cancer.»
Understanding these pathways, and the identification of the key proteins that control the ability of cancer cells to reprogram their metabolism through biochemical, and epigenetic or genetic alterations that make them resistant to therapies, is of paramount importance for the design of more targeted and therefore less toxic therapies.
For example, the discovery of cancer - causing genetic and epigenetic changes in tumors has enabled the development of therapies that target these changes as well as diagnostic tests that identify patients who may benefit from these therapies.
Increased understanding of epigenetic disease mechanisms, including natural and anthropogenic environment factors, could lead to disease risk stratification for targeted intervention and to targeted therapies.
Increased understanding of epigenetic disease mechanisms could lead to disease risk stratification for targeted intervention and to targeted therapies [6].
Epigenetic Therapy A novel two - drug treatment targets epigenetic alterations that help give cancer cells tEpigenetic Therapy A novel two - drug treatment targets epigenetic alterations that help give cancer cells tepigenetic alterations that help give cancer cells their edge.
In particular, Dr. Azad's laboratory and clinical trials explore epigenetic therapy in combination with chemotherapy and immunotherapy to improve survival for patients, as well as molecularly targeted drugs.
Understanding epigenetic mechanisms and their contribution to the persistence of diabetic complications is critical because it could suggest alternative targets for therapy to halt and reverse complications.
«This offers the opportunity for development of epigenetic targeted therapies for patients with ALL that could be broadly applicable to many patients.»