Sentences with phrase «targeted phages»

For example, specially targeted phages have been suggested as a possible therapy for conditions like cystic fibrosis, which is caused by frequent bacterial lung infections.

In one experiment, the ARS researchers inoculated melon slices with a million Salmonella and then spritzed on a flavorfree solution containing 100 million Salmonella - targeting phages.

The findings mean that drugs that target phages could offer a potential new path to mitigate antibiotic resistance.

Not exact matches

The antibiotic, Epimerox, targets weaknesses in bacteria that have long been exploited by viruses that attack them, known as phage, and has even been shown to protect animals from fatal infection by Bacillus anthracis, the bacteria that causes anthrax.

«The long - term evolutionary interaction between phage and bacteria has allowed us to identify targets that bacteria can not easily change or circumvent.

Unlike antibiotics, which act like sledgehammers, wiping out all bacteria, phages specifically target single strains of these germs, leaving beneficial microbes unharmed.

Fischetti and his colleagues used a phage - encoded molecule to identify a bacterial target enzyme called 2 - epimerase, which is used by Bacillus anthracis to synthesize an essential cell wall structure.

«We're taking advantage of what phage have «learned» during this period for us to identify new antibiotic targets that we believe will escape the problem of resistance found for other antibiotics.»

Since phages have evolved with their bacterial targets for billions of years, they could solve the problem of antibiotic resistance for good; the downside is that each bacterial strain requires its own tailored phage cocktail, so it could be many years before doctors have a suitably broad range of phages at their disposal.

Each strain of phage is highly targeted and has evolved to home in on specific bacteria, which means a precise match between prey and predator is necessary for any phage - based treatment to be effective.

Unraveling the underlying mechanism could help pave the way toward making phages a targeted therapy for diseases like cholera.

Bellen and Venken attached artificial docking sites to phages — a virus that targets bacteria — which they introduced in both the bacteria and in the fruit fly genomes to act as sticky points for the DNA segment being implanted in the latter's genome.

With no candidate targets, the team took an objective approach by applying a peptide phage library to MDSCs, which permitted mass screening for candidate peptides — short sequences of amino acids — that bind to the surface of the MDSCs.

Engineered phage viruses show promise as targeted assassins - genetic manipulation might make it easier for them to gain regulatory approval

Now, the team has found that another type of dwarf phage also targets a gene responsible for a cell wall - building enzyme.

Thus, the two small phages characterized for their lysis strategy, Qβ and the small DNA phage φX174, effect host lysis by targeting different enzymes in the multistep, universally conserved pathway of cell wall biosynthesis.

But when the researchers added a phage that targets E. coli to the cultures, survival rates skyrocketed for the mucus - producing cells.

These phage libraries have tremendous diversity, so you can use them to find very unique antibody protein sequences that target specific molecules within disease pathways,» says Coyle.

Together with CSL we embarked on a collaborative project aiming to identify novel antibodies to target melanoma cells using phage display technology.

After the last coffee break Emmanuelle Charpentier (Umeå University, Sweden) entered the scene and shared her knowledge about how to use phages (viruses that target bacteria) for genome engineering via CRISPRs.

Liu J, Lubelski D, Schonberg D, Wu Q, Hale J, Flavahan W, Man J, Hjelmeland A, Yu JS, Lathia J, Mulkearns - Hubert E, Rich JN, Phage Display Discovery of Novel Molecular Targets in Glioblastoma Initiating Cells.