At one level, optogenetics is nothing more than using light to control
a targeted population of cells.
Not exact matches
«A biological approach to precision medicine
targets endless number
of diseases: Self - assembling platform effectively delivers inhibitory RNA molecules to
targeted cell populations.»
Participants with high - risk bacterial communities, which are commonly found in the
population of women studied, also had increased numbers
of genital CD4 + T
cells — white blood
cells that are HIV's primary
target.
Another hypothesis is that progesterone boosts the
population of Langerhans
cells in the vaginal mucosa, thought to be one
of the main
targets of HIV in the female genital tract.
When coexpressed with a recombinase, these intracellularly expressed ssDNAs
target specific genomic DNA addresses, resulting in precise mutations that accumulate in
cell populations as a function
of the magnitude and duration
of the inputs.
The second branch
of the combination therapy, the low - dose metronomic chemotherapy, was similarly found to exert its therapeutic effect through a novel, hitherto unrecognized mechanism: The metronomic chemotherapy turned out to not primarily
target the tumor
cells, but to act on the recruitment
of yet another tumor - promoting
cell population from the bone marrow.
Targeting the labeled
cells for analysis, they revealed that their organoids contained a
population of sensory
cells that have the same functional signature as
cells that detect gravity and motion in the human inner ear.
The selection strategy
targeted cell populations expressing the inducible endothelial
cell adhesion molecules, E-selectin and VCAM - 1, and proved successful in generating microvascular endothelial
cell lines from a number
of different organs.
Thus, our selection strategies, which were based on
targeting endothelial
populations that expressed both
of these inducible glycoproteins, suggest that the endothelial
cell lines generated in this study are most likely from this microcirculatory region.
The team used a combination
of experiments to zero in on the molecular activity
of melittin at the «minimal inhibitory concentration» (MIC), the lowest concentration that's been shown to slow the growth
of target cell populations.
«The successful retrieval
of memories in AD mice by increasing the number
of spines for normal memory processing only in the memory
cells, rather than in a broad
population of cells, highlights the importance
of highly -
targeted manipulation
of neurons and their circuits for future therapies.
«The successful retrieval
of memories in AD mice by increasing the number
of spines for normal memory processing only in the memory
cells, rather than in a broad
population of cells, highlights the importance
of highly -
targeted manipulation
of neurons and their circuits for future therapies,» said Tonegawa in a statement.
Unlike other studies on p53, however, which
target cell populations that average many
cells together, Dr. Lahav developed a new approach, quantifying p53 at high temporal resolution in single
cells and taking into account that «individual
cell decisions are crucial in the development and treatment
of cancer.»
When using the ClonTracer system, lentiviruses containing these barcodes infect the
target cell population at low multiplicity
of infection (MOI) such that each individual
cell receives only one barcode.
With the discovery
of VHL alterations in the majority
of clear
cell RCCs,
targeted therapies were studied in this
population.
The focus is on molecular microbiology and virology, and includes topics such as genomics, the gamut
of plant and animal host - pathogen interactions, host immune responses, characterization and evolution
of virulence determinants,
cell cycle and differentiation, symbiosis in plant and animal associations, environmental microbiology, biodiversity and evolution,
population dynamics, sex and mutagenesis, antibiotic resistance and production, drug and vaccine
targets, as well as aspects
of prion diseases and
of fungal and protozoan biology.
The players are the healthy
cells, the
targeted cancer
cells and the resistant cancer
cells and the game is played over and over again in the computer simulation as the different
populations of cells compete.
Sorting breast cancer
cells using a new reporter construct allows the interrogation
of a highly pure
population of cancer stem
cells and may allow for the discovery
of new therapeutic
targets
New CFSE - based assay to determine susceptibility to lysis by cytotoxic T
cells of leukemic precursor
cells within a heterogeneous
target cell population.
In 2016, Dmitry I. Gabrilovich, M.D., Ph.D., program leader
of Wistar's Translational Tumor Immunology program, and his research team identified a marker for myeloid - derived suppressor
cells (MDSCs), a
population of immune
cells implicated in tumor resistance to various types
of cancer treatment, including
targeted therapies, chemotherapy and immunotherapy.
We show enzymatic
targeting of an NMDA - R antagonist, MK801, to a molecularly defined neuronal
population with the
cell - type - selectivity
of genetic methods and the temporal control
of pharmacology.