Sentences with phrase «targeted sequencing study»

We also worked with Sam Stanley on a targeted sequencing study to characterize the immunogenetics of smallpox vaccination.

Not exact matches

Phase I funding — which allows up to $ 250,000 for an academic idea, such as decoding the genetic sequence of a protein or studying targeted drug delivery by using magnetic nanoparticles — is available from federal funding and foundations.

In the study, whole - exome sequencing and a targeted analysis of 90 genes implicated in heart disease were applied to 419 unrelated SIDS cases.

«We hope our findings will encourage others to use whole - genome sequencing as a method to determine all the off - target effects of their CRISPR techniques and study different versions for the safest, most accurate editing,» Dr. Tsang says.

Weiner, Elliott and colleagues studied the DNA sequences for two human monoclonal antibodies — one able to broadly target influenza A viruses and one able to broadly target influenza B viruses — with collaborators at Inovio and MedImmune.

The larger scale Cancer Genome Atlas study provided the information needed to alter proteins or RNA sequences that may act as «drivers» for prognostic biomarkers or therapeutic targets.

The study adds to evidence that gene editing may need to be adapted to each patient's genome, to ensure there aren't variants in DNA sequence in or near the gene being targeted that would throw off the technology.

During the last three years the Spanish Consortium for the Study of the Genome of the Chronic Lymphatic Leukemia, where the researchers of the present study already collaborate, has sequenced the genome of hundreds of patients with the more common leukemia in our society, identifying new mechanisms of tumor progression and new therapeutic tarStudy of the Genome of the Chronic Lymphatic Leukemia, where the researchers of the present study already collaborate, has sequenced the genome of hundreds of patients with the more common leukemia in our society, identifying new mechanisms of tumor progression and new therapeutic tarstudy already collaborate, has sequenced the genome of hundreds of patients with the more common leukemia in our society, identifying new mechanisms of tumor progression and new therapeutic targets.

In an attempt to answer these issues, a recent study of 31 target spider species from the Naturalis Biodiversity Center in Leiden, discovers that both time and body size are significant factors in determining which specimens can produce DNA barcode sequences.

Canadian researchers conducted a pilot study with 20 newborns to determine the effectiveness of a targeted next - generation sequencing panel that included all 4813 genes currently known to be associated with rare diseases.

«Nearly every animal has these small RNAs, and they use them as a guide to look for target sequences and silence them,» said Heng - Chi Lee, PhD, assistant professor of molecular genetics and cell biology at UChicago and senior author of the new study.

Previous studies had shown that, paradoxically, certain mismatches between a guide RNA and its target sequence don't affect Cas9's ability to cleave a specific site in the DNA.

CRISPR, originally discovered by biologists studying the bacterial immune system, consists of a DNA - cutting enzyme called Cas9 and short RNA guide strands that target specific sequences of the genome, telling Cas9 where to make its cuts.

«Our results reveal two major functions of the PAM that explain why it is so critical to the ability of Cas9 to target and cleave DNA sequences matching the guide RNA,» says Jennifer Doudna, the biochemist who led this study.

Several methodologies for performing DNA target enrichment prior to next generation sequencing have been developed and utilized in a growing number of experimental studies.

Additional studies in which we more precisely define the mechanisms of resistance and growth in an individual's tumor with genomic sequencing, and other means, will be important to maximize the ability to target all the critical pathways to achieve greater success.»

«These sequences then become the targets for a far narrower set of follow - up gene function studies in F. graminearum by reverse genetic experimentation to pinpoint the genes essential for the disease - causing abilities of this pathogen.»

Sarah Weckhuysen and colleagues report a study based on targeted sequencing of the genes encoding the components of the GATOR1 (DEPDC5, NPRL2, and NPRL3) and GATOR2 (MIOS, SEC13, SEH1L, WDR24, and WDR59) complex in European probands with focal epilepsy with or without focal cortical dysplasia.

Molecular studies of Hox - regulated target genes suggest that these changes occur through accumulation of mutations in regulatory DNA sequences.

According to the previous study, the Cas13a enzyme can be programmed to target specific sequences in viral and bacterial cells and still remain active afterwards.

The availability of a new and improved P. cynomolgi reference genome sequence will enable in - depth studies of this widely used model parasite, including investigations into dormant stages and the selection of new drug targets and vaccine candidates.

First observed in B - cell lymphoma, recurrent mutations of epigenetic modifier genes have recently been identified in PTCL - NOS. 9 In the present study, we performed targeted sequencing of the main epigenetic modifier genes in a large cohort of Chinese PTCL - NOS patients.

The most noticeable editing events found in this study occurred in the short part of the miRNA sequence that is necessary for correct target binding.

But rather than changes in doublesex itself, these studies revealed changes in downstream targets of dsx, via changes to specific DNA sequences to which DSX protein binds in the cis - regulatory regions of the bric - a-brac and desatF genes and affecting sex differences in abdominal pigmentation and pheromone production.

This month in Nature, a group from Jay Shendure's lab reported perhaps the most ambitious targeted resequencing study to date — the whole exome sequences of 12 individuals.

Modern disease studies rely heavily on exome sequencing, yet an adequate method for the detection of structural mosaicism using targeted sequencing data is lacking.

Using targeted and whole - exome sequencing, we studied 32 human and 87 rodent obesity genes in 2,548 severely obese children and 1,117 controls.

A study of 73 afterschool programs that targeted personal and social skills found that «solid» training approaches included sequenced activities to achieve skill objectives, active learning, and explicit focus on personal or social skills.