Sentences with phrase «targeted subset»

These funds attempt to enhance the performance of a portfolio that tracks a targeted subset of the market.

The reason for NOT expending effort tp «conduct a wide scale attempt» by targeting the subset of non-citizens is that it has been determined time and again that the number of non-citizens that attempt to vote is exceedingly low (but admittedly greater than zero).

Recent research indicates that selectively targeting subsets of a species can drive unwanted population shifts — say, drastically reducing the number of males relative to females — or even genetic and behavioral changes.

The study indicates school districts will need to focus professional development on more in - depth instructional need, targeting a subset of teachers who need the most guidance.

In both cases, Skype is targeting a subset of its users with features built just for them.

Not exact matches

Only a small subset of issuers — 24 or 13 % — have set measurable targets.

The project is detailed in the contract as a seven step process — with Kogan's company, GSR, generating an initial seed sample (though it does not specify how large this is here) using «online panels»; analyzing this seed training data using its own «psychometric inventories» to try to determine personality categories; the next step is Kogan's personality quiz app being deployed on Facebook to gather the full dataset from respondents and also to scrape a subset of data from their Facebook friends (here it notes: «upon consent of the respondent, the GS Technology scrapes and retains the respondent's Facebook profile and a quantity of data on that respondent's Facebook friends»); step 4 involves the psychometric data from the seed sample, plus the Facebook profile data and friend data all being run through proprietary modeling algorithms — which the contract specifies are based on using Facebook likes to predict personality scores, with the stated aim of predicting the «psychological, dispositional and / or attitudinal facets of each Facebook record»; this then generates a series of scores per Facebook profile; step 6 is to match these psychometrically scored profiles with voter record data held by SCL — with the goal of matching (and thus scoring) at least 2M voter records for targeting voters across the 11 states; the final step is for matched records to be returned to SCL, which would then be in a position to craft messages to voters based on their modeled psychometric scores.

The data was acquired and processed by Cambridge University professor Aleksandr Kogan whose personality quiz app, running on Facebook's platform in 2014, was able to harvest personal data on tens of millions of users (a subset of which Kogan turned into psychological profiles for CA to use for targeting political messaging at US voters).

It said a «a reasonable connection» can be made «that Gov. Cuomo targeting a specific subset of an industry that would — to the exclusion of all other businesses. . .

Associate professor Mary - Ellen Taplin, of the Dana - Farber Cancer Institute, Boston, USA, will tell the 26th EORTC - NCI - AACR Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, Spain, that galeterone was well tolerated by patients in the ARMOR2 trial, and also lowered PSA levels in a subset of men with CRPC that was resistant to other drugs that target the cancer, such as enzalutamide and abiraterone.

Researchers targeting a small subset of tumor markers would end up paying for extra controls they didn't need.

«This may serve as a clinically useful biomarker to identify a subset of difficult - to - treat asthmatic children, and targeting the VNN - 1 pathway may be useful as a therapeutic strategy.»

«Our data suggests that targeting specific immune cell subsets at defined stages of disease may represent a better approach to therapeutic immunomodulation to improve heart failure.»

«We introduce a gene that encodes a light - sensitive protein, and we target the expression of that gene to a subset of retinal cells.»

In a randomized, phase 2 multi-center clinical study, led by Manisha Shah, MD of The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James), investigators tested the effectiveness of the targeted therapy drug, dabrafenib (pronounced «da bRAF e nib» and marketed as Tafinlar), given alone compared with the same drug given in combination with trametinib (pronounced «tra ME ti nib,» marketed at MeKinist) to treat a subset of advanced papillary thyroid cancer patients with B - raf mutations.

He benefits from a medication that targets the underlying cause of the disease for a small subset of cystic fibrosis patients.»

The study suggests that attacking those subsets with targeted drugs may degrade the disease's ability to spread throughout the bone marrow of affected patients, the authors say.

We show here that in a subset of these systems, the mature crRNA that is base - paired to trans - activating crRNA (tracrRNA) forms a two - RNA structure that directs the CRISPR - associated protein Cas9 to introduce double - stranded (ds) breaks in target DNA.

Targeting particular subsets electrically or pharmacologically may bypass clinical side effects.

«The results of our study could offer new treatment to this population of patients, identifying a subset of malignant pleural mesothelioma who expressed PD - L1 and could be treated with targeted therapies to PD - L1,» Cedres says.

He thinks a number of cancer cell subsets are never really affected by most targeted anticancer drugs currently used.

«The discovery of these new, natural grape - derived polyphenol compounds targeting cellular and molecular pathways associated with inflammation may provide an effective way to treat a subset of people with depression and anxiety, a condition that affects so many people.»

They hope to identify the complete set of DNA binding sites and corresponding target genes for the regulons in embryonic stem cells and a subset of the cells they differentiate into.

Firestein, who is also director of the Clinical and Translational Research Institute at UC San Diego, said the work «opens up the potential for precision medicine approaches that allow us to target all of the joints, not just a subset.

A T - cell marker panel that can identify subsets of tumor - associated T - cells allows scientists to identify and target subpopulations of T - cells playing unique roles in the immune response against a tumor.

The study also showed that WGS identified more clinically actionable mutations than the current standard of examining a limited subset of genes, known as a targeted panel.

However, it is also possible to induce such responses using protein antigens, if there is a signal that promotes cross-presentation and targeting to specific dendritic cell (DC) subsets with the capacity to cross-present antigens.

The mismatch repair defective subset of CRC selectively up - regulates at least 5 checkpoint molecules that are targets of inhibitors currently being clinically tested.

Either way, this subset of CD4 + T cells could become a target for eradicating the virus.

Because our current understanding suggests these molecules control many functional activities of T cells, and the effects might vary depending on the subset of T cell, they are therefore potential targets for either suppressing an immune response, or for promoting an immune response.

With their deep expertise in the biology of senescent cells, the Campisi lab will be focused on fundamental research into questions like how senescent cells vary in their susceptibility and resistance to immune clearance (depending on factors like their tissues of residence or the pathway that led them into senescence); the targets and mechanisms used by NK cells to clear senescent cells; and why subsets of senescent cells might persist when their similarly - situated neighbors are cleared out (and what might allow us to overcome that resistance).

In addition, the CD8 subset primarily function as cytolytic killers for clearing pathogen - infected cells or for targeting tumors.

Targeted drugs and combination therapies can drive cancer into remission, as they achieve optimal results in subsets of patients.

Because of their ability to differentiate into various effector T subsets, Th1, Th2, Th17, and Tregs, CD4 + T cells are particularly important in the initiation of GVHD in mice and have been considered potential targets for the treatment and prevention of GVHD in the clinic.

We investigate which CD4 T cell subsets serve as predominant niches for viral long - term persistence, and aim at identifying specific molecular pathways in these cells that can be targeted to reduce viral persistence.

These mutant kinases are attractive therapeutic targets, as demonstrated by the efficacy of imatinib in BCR - ABL — positive chronic myelogenous leukemia (CML), 5 as well as in MPD associated with activating alleles involving PDGFRA or PDGFRB.2, 6,7 In addition, activating mutations in the FLT3 receptor tyrosine kinase are the most common genetic event in acute myeloid leukemia (AML), and specific inhibitors of the FMS - like tyrosine kinase 3 (FLT3) have entered late - stage clinical trials.8 Although mutations in tyrosine kinases and in other genes have been identified in a subset of MPD and AML, in many cases the genetic events that contribute to the molecular pathogenesis of these diseases remain unknown.

It is the first treatment targeting the underlying cause of CF in a subset of patients with a specific mutation.

This modification is of special interest to p53 - dependent anti-senescence and pro-longevity functions because genetically engineered mice with p53 serine18 mutated to alanine (p53S18A) show increased ROS levels, metabolic stress, tumor frequency, premature aging symptoms and defects in regulation of a subset of p53 target genes that include sestrins.

Both the transcriptome and the target enrichment datasets were collected using an identical sampling strategy (six individuals from each subspecies collected away from the contact zone) but each dataset derives from a different subset of individuals.

Our baseline suite of test cases includes one calculation for all filter modes with the same target, plus one subset for all kinds of targets through the same filter.

High - resolution maps of enhancer - promoter interactions in rare primary human T cell subsets and coronary artery smooth muscle cells link variants associated with autoimmune and cardiovascular diseases to target genes.

In addition, HER2 is expressed in many normal tissues, giving systemic HER2 - targeted antibody therapy the potential to cause toxicity in a subset of patients, including cardiac myopathy, congestive heart failure, and pulmonary toxicity [14], [15].

As all of these Oct4 homodimer and heterodimer conformations bind distinct DNA motifs, a signaling - based mechanism could potentially control the transcription of distinct subsets of Oct4 target genes.

Surprisingly, small molecule activators of PKA signaling increase expression of Oct4 protein, which in turn enhances expression of a specific subset of Oct4 target genes.

But TESS is still targeting a specific subset of stars: It is focused on small bright stars that are fairly close to Earth.

A subset of these miRNA knockout lines are «cluster» knockouts in which more than one gene has been targeted.

Analysis of FOXP2 gene targets in human neural tissues reveal that a subset of these play roles in activity - based sculpting of neural connections, including during learning [48], [49].

Modeling mRNA expression heterogeneity in tumors through bimodal profiles is a novel powerful approach with the potential to uncover therapeutic targets that benefit subsets of cancer patients.

Most respondents supported the idea of selecting subsets of the proposed patterns to target various audiences, but the recommendations varied widely as to what these subsets should be.

Despite being owned by AFF and representing a subset of the main AFF database, ALT have made a big effort to tailor the website to their targeted demographic.