Sentences with phrase «targeted therapies in»

Thus our studies on MELK are critical for guiding the development of targeted therapies in basal - like breast cancer.

Now, we're conducting clinical trials to test these targeted therapies in combination with immunotherapy to treat KRAS - driven NSCLC.

His research aims to understand mechanisms of resistance to targeted therapies in cancer and identify potential therapies to overcome that resistance.

However, for the majority targeted therapies in development — and their combinations with current standard therapies — there are still no approved diagnostic tools to determine which patients are most likely to benefit from or be resistant to these novel agents or drug combinations.

She has also obtained a Breast Cancer Research Foundation American Association for Cancer Research (BCRF - AACR) Grant for Translational Breast Cancer Research to explore combined endocrine and ErbB inhibition in ER + / HER2 + breast cancers in 2007, a K23 Career Development Award to explore targeted therapies in breast cancer, and is also co-Leader in three of the four research projects of the NCI - funded Vanderbilt Breast Cancer Specialized Program of Research Excellence (SPORE; Carlos Arteaga, Director).

She has intensively worked in translational projects related to targeted therapies in breast cancer, obtaining a Pilot Project from the Breast Cancer SPORE in 2005.

Jun. 14, 2017 — A PET probe that detects the amino acid glutamine predicts whether tumors respond to certain targeted therapies in preclinical animal models.

The investigators also looked into the effect of HER2 - targeted therapies in these patients.

«The field of targeted therapies in gliomas holds a lot of promise, and IL13Rα2 is in an optimal position to materialize these promises,» explained corresponding author Sadhak Sengupta, PhD, assistant professor of neurosurgery at BUSM and principal investigator of the Brain Tumor Lab at Roger Williams.

«The survival benefit is clearly significant and supports future efforts to study multiple targeted therapies in earlier disease settings.

«If resistance that is this complex is constantly evolving before us, it may mean we need multiple targeted therapies in combination to stay ahead of the resistant cancer,» said Geoffrey Oxnard, MD, a thoracic oncologist and lung cancer researcher at Dana - Farber and senior author of the report.

Although other cancer - associated proteins have been successfully attacked with targeted therapies in recent years, the myc protein has continued to elude efforts to develop drugs that target it.

The research group will now focuse on comparing the efficacy of this therapy with other targeted therapies in patients with PI3K mutations.

Researchers are already beginning to test combinations of targeted therapies in the clinic.

«Precision medicine is already positively affecting providers (for example, by reducing ED visits by 30 % through application of molecular profiling treatment strategy); payers ($ 25 billion expected annual spending on genetic tests by 2021, and 45 % of FDA approvals were geared toward targeted therapies in 2013); and pharma (the pharmacogenomics market is expected to be $ 7.5 billion by 2017).»

Cambridge, MA — March 30, 2017 — Aura Biosciences, a biotechnology company developing a new class of therapies to target and selectively destroy cancer cells using viral nanoparticle conjugates, announced today that it has enrolled and dosed the first patient in its Phase 1b clinical trial of light - activated AU - 011, an investigational, first - in - class targeted therapy in development for the treatment of ocular melanoma, a rare and life - threatening disease.

Targeted therapy in advanced metastatic colorectal cancer: Current concepts and perspectives.

Not exact matches

I won't reveal yet who my favorites are, but I will say that these young scientist - founders came up with very creative solutions for preventing infections in some common surgeries, tackling resistance in targeted antibody drugs, improving gene vectors for cell therapies, helping the vision - impaired «see» faces and better read their environments, imaging hard - to - see spots in the lungs and other organs, improving genetic risk analysis, and expediting the logistical operations of hospitals.

Luxturna is the first of a crop of treatments that target diseases caused by mutations in specific genes, and thus is referred to by many as the first gene therapy in the U.S.

That led to an earlier Food and Drug Administration (FDA) approval for Keytruda than Opdivo in 2014 since the former was a more targeted therapy; but it also left Merck with a smaller slice of the market.

Groups is very simple: For $ 65 a week, it offers group therapy in areas plagued by opioid addiction — targeting towns with fewer than 10,000 residents and little access to recovery programs — so people at different stages of recovery can learn from one another.

«The sale of the PRV provides an important source of non-dilutive capital to support the rapid advancement of our follow on exon skipping candidates and next generation RNA targeted antisense platform,» he said in a statement, referring to the action mechanism used by the company's therapies.

«Data and insight that comes directly from patient records — real - world evidence — is transforming how pharmaceutical and life science companies develop more precise, targeted therapies,» said Cota CEO John Hervey in a statement.

The Kamens claim the main thing that distinguishes their foundation from other brain tumor foundations is their focus on pediatric brain cancer specifically, as well as their close ties with pharmaceutical and biotech companies working in the fields of immunotherapy and target gene therapy.

But he adds that the industry has entered a new cycle where targeted therapies, particularly in cancer treatments, means there are some good returns on R&D.

Cambridge, MA — February 6, 2017 — Aura Biosciences, a biotechnology company developing a new class of therapies to target and selectively destroy cancer cells using viral nanoparticle conjugates, announced today that the U.S. Food and Drug Administration (FDA) has cleared the investigational new drug application (IND) for the company's lead program, light - activated AU - 011 in ocular melanoma (OM).

That therapy for treating melanoma is already in the development pipeline, along with 906 other biologics targeting over 100 diseases from autoimmune disorders to viruses.

What Stephen Hawking Missed: Small Biotechs Developing Promising Cell Therapies for Devastating Disease Source: Streetwise Reports (5/2/18) In the second of a two - part series exploring the disruptive cell therapy space, Maxim Group analyst Jason McCarthy takes a look at small - cap companies targeting big - ticket indications and their potential to drive blockbuster value for both patients and investors.

Incyte's (NASDAQ: INCY) Jakafi racked up $ 1.1 billion in sales last year as the only targeted therapy for patients with myelofibrosis, but a majority of patients who take it eventually relapse.

He tells us that the true victims of false incest memories were not the accused father figures, nor the ruined families: «The real targets of recovered memory therapy were the women in whom treatment cultivated such a debilitating sense of vulnerability and helplessness.»

«Liberal Democrats in Government have been leading a mental health revolution, boosting investment in talking therapies and putting mental health on an equal footing with physical health in terms of waiting time targets.

«These new insights into the complexities of epigenetic regulation are contributing to our basic understanding of this process in human health and disease and gives us new vision for how to go about targeting errors in DNA methylation with innovative drug therapies.»

Drugs that impact DNA methylation are increasingly a target for drug development; in fact, several of these therapies are already in clinical use for certain cancers.

«For us, it's very important to understand the neural circuits or pathways so that we can develop therapies specifically for pain or itch, instead of targeting it as a whole system,» says Santosh Mishra, assistant professor of neuroscience in NC State's College of Veterinary Medicine and the corresponding author of a paper on the topic.

The idea was «to identify the areas of the brain in which p11 is particularly important, in order to find targets» for new therapies for depression, says Kaplitt.

As the first targeted therapies edge towards regulatory approval, attention turns to the next drugs in line.

The study, published online today in Science Translational Medicine, further points to a master switch for these gene sets as a potential target of future therapies.

In Solms and Panksepp's vision of the future, depression treatment might blend various types of therapy — sometimes including psychoanalysis — with drug regimens designed to target the neural circuitry involved in a well - understood emotional responsIn Solms and Panksepp's vision of the future, depression treatment might blend various types of therapy — sometimes including psychoanalysis — with drug regimens designed to target the neural circuitry involved in a well - understood emotional responsin a well - understood emotional response.

This prognosis guides decisions for subsequent courses of targeted therapy, and further biopsies are not routinely obtained, given the invasive nature of rebiopsy in the lungs.

Recent advances in the understanding of cancer have led to more personalized therapies, such as drugs that target particular proteins and tests that analyze gene expression patterns in tumors to predict a patient's response to therapy.

Happily, according to the researchers» report in the Journal of Allergy and Clinical Immunology, they were able not only to describe the new mutation, but also to successfully treat the patient with targeted therapy.

His team discovered that treatment - resistant melanoma tumors, in what is akin to drug addiction, develop a dependency on MAPK - targeted therapy to retain their fitness.

«Current therapies in clinical trials are focused on targeting genetic changes in tumors and helping to boost one's immune system to fight the cancer cells.

Prof. Severine Vermeire (KU Leuven / UZ Leuven): «In the future, gut bacteria may be used to help identify PSC patients with a more or less aggressive disease, or patients that may benefit from microbiota - based therapies, such as fecal microbiota transplantation or targeted pre - and probiotics.»

Researchers at New York University College of Dentistry (NYU Dentistry) have described a new target that may open the door to developing therapies for preventing bone fractures in people with type 2 diabetes.

Biological markers could enable tailored therapies that target individual differences in symptoms

By combining this strategy with cancer cell - targeting materials, we should be able to develop a therapy for glioblastoma and other challenging cancers in the future.»

The investigators» experiments in mice suggest that the receptors» activation directly aggravates airway constriction and — if the same process is active in people — may be a promising new target for the development of drug therapies.

Clinical trials for targeted therapies, selected on the basis of the genomic tests, are scheduled to begin in early 2007.

«Considering that PDPN is associated with poor prognosis in GBM, CAR T - cell therapy that targets this protein is promising for treatment of patients with relapsed or resistant tumors following first - line chemotherapy,» says Toshihiko Wakabayashi, a coauthor and the chair of Department of Neurosurgery Nagoya University School of Medicine.