Sentences with phrase «targeted therapy using»

«Our study's positive results may lead the way to developing a more targeted therapy using steroids to quickly restore the integrity and function of the BBB after bTBI.»

Targeted therapy using MDSC - inhibiting drugs, such as cabozantinib (Cabo) and BEZ, also demonstrated minimal anti-tumor capabilities.

The primary aim is to investigate the use of targeted therapy using antibodies and antibody - conjugates and remove toxic chemotherapy and radiation from the treatment to maintain high cure rates and decrease late effects.

Bottom Line: Young mice that received molecularly targeted therapies used to treat brain cancer in human patients sustained cognitive and behavioral deficits, but the deficits were largely reversible through environmental stimulation and physical exercise.

Not exact matches

The start - up's premiere product, the Thin Ice vest, uses cold therapy to target areas of the body with high concentrations of thermoreceptors, which are nerve cells that are able to detect the presence of hot or cold temperatures.

Gene therapy, for example, frequently involves using a virus to deliver a gene to the cells that scientists are targeting.

«The sale of the PRV provides an important source of non-dilutive capital to support the rapid advancement of our follow on exon skipping candidates and next generation RNA targeted antisense platform,» he said in a statement, referring to the action mechanism used by the company's therapies.

• The use of biotech to provide precision medicine for targeted therapies.

Cambridge, MA — February 6, 2017 — Aura Biosciences, a biotechnology company developing a new class of therapies to target and selectively destroy cancer cells using viral nanoparticle conjugates, announced today that the U.S. Food and Drug Administration (FDA) has cleared the investigational new drug application (IND) for the company's lead program, light - activated AU - 011 in ocular melanoma (OM).

Cambridge, MA — December 21, 2017 — Aura Biosciences, a biotechnology company developing a new class of therapies to target and selectively destroy cancer cells using viral nanoparticle conjugates, announced today that it closed a $ 30 million Series C financing.

Cambridge, MA — March 30, 2017 — Aura Biosciences, a biotechnology company developing a new class of therapies to target and selectively destroy cancer cells using viral nanoparticle conjugates, announced today that it has enrolled and dosed the first patient in its Phase 1b clinical trial of light - activated AU - 011, an investigational, first - in - class targeted therapy in development for the treatment of ocular melanoma, a rare and life - threatening disease.

But I think it is long past time to consider the value of other approaches, including the targeted use of drug therapies.

Drugs that impact DNA methylation are increasingly a target for drug development; in fact, several of these therapies are already in clinical use for certain cancers.

Unlike conventional chemotherapies and radiation that indiscriminately eradicate fast - growing tissues and ravage people's bodies with side effects, new therapies specifically target tumors using tailored cells from individual patients.

Prof. Severine Vermeire (KU Leuven / UZ Leuven): «In the future, gut bacteria may be used to help identify PSC patients with a more or less aggressive disease, or patients that may benefit from microbiota - based therapies, such as fecal microbiota transplantation or targeted pre - and probiotics.»

The finding suggests that other AAVs used for a gene therapy targeting the brain or spinal cord might be improved by having the same or a similar set of amino acids.

To address this challenge, our research group is using nanoparticles not only to deliver more chemotherapy drugs to the target site within cancer cells, but also to compromise the function of the efflux pumps and thereby significantly improve safety and efficacy of cancer therapy.»

«We were hoping to find targets we can use for therapy and we were also trying to figure out molecular differences in different types of epilepsy.

However, they determined the blood levels of SMN are not altered when SMN levels are altered in motor neurons using a gene therapy approach delivered directly into the cerebrospinal fluid to target the central nervous system.

Importantly, while using rosiglitazone in conjunction with targeted therapy reduced tumor growth in both young and aged pre-clinical models, using rosiglitazone alone accelerated tumor growth in young models, while inhibiting it in aged ones.

This new technology offers two main advantages based on the use of molecular tools to manipulate the genome: firstly, working models that had not existed up until now for the study of tumour biology and, secondly, their application will eventually allow for the study of new therapeutic targets and therapies.

Researchers at The University of Texas MD Anderson Cancer Center developed a novel chimeric mouse model to test the combination therapy using immune checkpoint blockades with therapies targeting myeloid - derived suppressor cells (MDSCs).

«Inhibiting mTOR signaling using everolimus, a targeted therapy, known as a rapalog, for patients with lung and gastroenteropancreatic NETs, has been approved by the FDA.

The researchers found a set of frequently mutated genes in SBAs that could be helpful to clinicians when they are looking to use targeted therapies that work best in cancers with specifics mutations.

«In order to block tumor recurrence after radiation therapy, we used an antibody to target and inhibit these cancer stem cells,» said Dr. Xu.

Treatment for advanced melanoma has seen success with targeted therapies — drugs that interfere with division and growth of cancer cells by targeting key molecules — especially when multiple drugs are used in combination.

These results not only show promise on a new targeted therapy to treat this malignancy, as PI3K inhibitors are already used in the clinical practice, but also unravel a new function of the PI3K kinase in cancer biology through its role in promoting metastasis.

One way to do this is to use combinations of targeted therapies.

While this could not heal or replace an entire body's worth of diseased muscle, it could be used in tandem with more widely targeted genetic therapies or to heal more localized problems.

«Potential targeted therapy for lung cancer identified using fly model.»

«Knowing how language learners make use of statistical information may suggest ways we can target language therapies,» says Goldrick.

The researchers were able to reverse these epigenetic changes with the use of an FDA - approved drug, forcing the cancer cells out of hiding and potentially making them better targets for the same immune therapy that in the past may have failed.

Taken together, the results suggest a role for bile duct tissue microbiome in development of CCA and which may accordingly be used as a target for therapy.

The advantage of proton therapy is that there may be a procedure I could undergo in the future that uses targeted radiation to target the tumorous tissue and that could potentially kill off my tumor.

A research group at Boston's Massachusetts General Hospital, led by Tayyaba Hasan, has used nanocells and photodynamic therapy (light - activated chemicals) to target pancreatic cancer.

As for the future of adolescent substance use treatment, Drs. Chung & Black describe a need to focus on the «active ingredients» of therapies and their respective «targets.»

«Obviously, this information can be used in our efforts to identify drug therapies that kill cancer cells by targeting telomerase activity.»

Targeted Alpha Therapy of prostate cancer uses PSMA - 617, an anti-PSMA (Prostate Specific Membrane Antigen) peptide that specifically binds to prostate cancer cells, but not to normal, healthy cells.

Still, the standard form of liver - targeted gene therapy carries a range of potential complications, including the risk of harmful mutations and of the body mounting an immune response against the viral vectors used to carry the correct forms of the defective genes responsible for haemophilia.

In their report that has received advance online publication in Nature Nanotechnology, a research team based at the Wellman Center for Photomedicine at Massachusetts General Hospital (MGH) describes how a nanomedicine that combines photodynamic therapy — the use of light to trigger a chemical reaction — with a molecular therapy drug targeted against common treatment resistance pathways reduced a thousand-fold the dosage of the molecular therapy drug required to suppress tumor progression and metastatic outgrowth in an animal model.

Dr. Jones obtained his Ph.D. in 2003 from the University of Birmingham Institute of Cancer and Genomic Sciences (United Kingdom) under Professor Lawrence Young, studying the use of gene therapy for targeting Epstein - Barr Virus (EBV) proteins with replication - competent adenoviruses to treat EBV - driven malignancies.

As the central nervous system is also a target of AAV vectors, Hélène Puccio and Patrick Aubourg's teams are investigating whether a similar approach using gene therapy could be as effective for the spinal cord and cerebellum as it is for the heart.

The next step in the research should be to study the use of mindfulness - based therapies to target purpose in life and resulting sleep quality, said Arlener Turner, the study's first author and a former postdoctoral fellow in neurology at Feinberg.

Drugs used in targeted gene therapy operate by inhibiting one or more cellular processes.

The radiation used for cancer therapies is a much more targeted version of what exists in outer space, and exposure to that radiation presents a major health risk, and thus a serious challenge for NASA, SpaceX, and other organizations trying to explore the solar system.

Last year, she and her colleagues showed that the therapy could also be used to help halt HIV by targeting one of several viral proteins on the surface of HIV - infected cells.

Thus, finding new targets for drugs already in use to treat other diseases, in other words drug repurposing, is an emerging area in developing anti-cancer therapies.

Testing for the EGFR mutation and ALK rearrangements and the use of targeted therapies have given lung cancer patients the chance for survival, along with improved quality of life and time with loved ones.

This method, known as targeted radionuclide therapy, or TRT, involves the use of molecules labeled with radioactive atoms that are injected into patients and localized in cancer cells.

The bots might arrive at a clot, for example, and then using an internal power system, obliterate the clot with a precisely targeted drug or therapy.