Sentences with phrase «targeted treatment therapies»

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Furthermore, an early - stage study pumping up the dose of its hemophilia A treatment — which aims to be a one - time therapy for the rare blood clotting - related disease — appeared to hit its targets without serious side effects.

Luxturna is the first of a crop of treatments that target diseases caused by mutations in specific genes, and thus is referred to by many as the first gene therapy in the U.S.

But for all of the attention paid to its cancer drug pipeline, Bristol just scored a breakthrough therapy designation from the Food and Drug Administration for a treatment that targets hepatitis C.

«Precision medicine is already positively affecting providers (for example, by reducing ED visits by 30 % through application of molecular profiling treatment strategy); payers ($ 25 billion expected annual spending on genetic tests by 2021, and 45 % of FDA approvals were geared toward targeted therapies in 2013); and pharma (the pharmacogenomics market is expected to be $ 7.5 billion by 2017).»

But he adds that the industry has entered a new cycle where targeted therapies, particularly in cancer treatments, means there are some good returns on R&D.

This active IND enables Aura to begin initial clinical testing of AU - 011, a unique targeted therapy that could transform the primary treatment of patients with OM, a rare and life - threatening disease.

Cambridge, MA — March 30, 2017 — Aura Biosciences, a biotechnology company developing a new class of therapies to target and selectively destroy cancer cells using viral nanoparticle conjugates, announced today that it has enrolled and dosed the first patient in its Phase 1b clinical trial of light - activated AU - 011, an investigational, first - in - class targeted therapy in development for the treatment of ocular melanoma, a rare and life - threatening disease.

The bill primarily targets so - called «conversion therapy,» a type of counseling that remains controversial, and essentially operates under the principle that individuals can seek a sort of treatment (usually psychological) to change their sexual orientation.

He tells us that the true victims of false incest memories were not the accused father figures, nor the ruined families: «The real targets of recovered memory therapy were the women in whom treatment cultivated such a debilitating sense of vulnerability and helplessness.»

The plan includes a child's target range for blood glucose, when his glucose should be checked, his self - care skills, treatment protocals for hypoglycemia and hyperglycemia, and details about his insulin therapy.

The primary aim is to investigate the use of targeted therapy using antibodies and antibody - conjugates and remove toxic chemotherapy and radiation from the treatment to maintain high cure rates and decrease late effects.

In Solms and Panksepp's vision of the future, depression treatment might blend various types of therapy — sometimes including psychoanalysis — with drug regimens designed to target the neural circuitry involved in a well - understood emotional response.

His team discovered that treatment - resistant melanoma tumors, in what is akin to drug addiction, develop a dependency on MAPK - targeted therapy to retain their fitness.

However, not everyone's melanoma will benefit equally from MAPK - targeted therapies, and initial benefits might wane over time as tumors develop resistance to treatment.

For example, some cancer treatments, such as HER - 2 targeted therapies, can cause weakening of the heart muscle, a condition known as heart failure.

«The findings also suggest that therapies targeting the immune system may be effective treatments against this disorder and possibly other forms of epilepsy,» said Nath.

Therefore, common treatments such as endocrine therapy and molecular targeting of the HER - 2 receptor are not effective for this breast cancer subtype.

«Considering that PDPN is associated with poor prognosis in GBM, CAR T - cell therapy that targets this protein is promising for treatment of patients with relapsed or resistant tumors following first - line chemotherapy,» says Toshihiko Wakabayashi, a coauthor and the chair of Department of Neurosurgery Nagoya University School of Medicine.

To acquire new insights into the biology and possible therapy of these tumors, Feigin et al. looked for aberrant expression of G protein — coupled receptors, cell signaling proteins that have been successfully targeted for treatment of other disorders such as depression.

A better understanding of bacterial physiology of such slowly growing bacteria, could help us to shorten the duration of treatment with a more specifically targeted antibiotic therapy.»

«The Quanterix Simoa will accelerate the discovery of new biomarkers to identify TBI and the development of new treatments, including targeted medications and other therapies,» says Charles L. Marmar, MD, the Lucius Littauer professor and chairman of Psychiatry at NYU Langone and executive director of the Cohen Veterans Center.

The achievement could open the way to a genetic treatment against the growth of smooth muscle tissue that can block arteries in heart patients, and ultimately to other targeted gene therapies.

My cancer systems biology team at the University of California, Merced, is tackling diagnosis and treatment of therapy - resistant cancers by elucidating the network of changes within cells as a way to identify new drug targets and circumvent cancer resistance.

Over the past 2 decades, few effective treatments for this cancer type have been identified, as PanNETs» heterogeneity has complicated the design of targeted therapies.

Treatment for advanced melanoma has seen success with targeted therapies — drugs that interfere with division and growth of cancer cells by targeting key molecules — especially when multiple drugs are used in combination.

To that end, in collaboration with the University of Zurich and MD Anderson Cancer Center, the researchers tested melanoma tumor samples from human patients undergoing treatment with the same targeted therapies.

The development of targeted therapies has significantly improved the survival of melanoma patients over the last decade; however, patients often relapse because many therapies do not kill all of the tumor cells, and the remaining cells adapt to treatment and become resistant.

These new therapies could alleviate some of the problems plaguing current treatments for IBD, namely injections of antibodies that target and clear excess TNF.

«Although some non-small cell lung cancer patients have increased benefit of targeted therapy or immunotherapy instead of chemotherapy, for some groups of patients with NSNSCLC, chemotherapy has been the standard treatment for more than 30 years,» Gandhi notes.

Actionable gene mutations are defined by having a reported correlation with treatment outcome, a molecular association with a particular targeted therapy, or increasing pathologic - diagnostic accuracy.

«Thanks to a deeper understanding of cancer biology, we have a potential new targeted therapy for multiple myeloma, and can better tailor treatment for kids with Wilms tumor.

Little is known, however, about the metabolic pathways that drive the growth of individual glioblastoma subtypes — knowledge that is crucial for developing novel and effective targeted therapies that might improve treatment for these lethal tumors.

But therapies that target common molecular pathways active late in disease could be part of a multi-pronged treatment plan for people with these inherited conditions.

The depth and breadth of information obtained is promoting biomarker discovery, especially potential targets for drug therapies, as well as possibly enabling improved patient stratification for clinical trials and treatment protocols.

Next steps include pursuing therapies, including antibodies and herb - derived treatments, that target the misguided progenitor cells, instead of only targeting the cancerous breast tissue they produce, Ko said.

As for the future of adolescent substance use treatment, Drs. Chung & Black describe a need to focus on the «active ingredients» of therapies and their respective «targets.»

For all these early successes, biologists see targeted cancer therapy as a treatment rather than a cure.

In their report that has received advance online publication in Nature Nanotechnology, a research team based at the Wellman Center for Photomedicine at Massachusetts General Hospital (MGH) describes how a nanomedicine that combines photodynamic therapy — the use of light to trigger a chemical reaction — with a molecular therapy drug targeted against common treatment resistance pathways reduced a thousand-fold the dosage of the molecular therapy drug required to suppress tumor progression and metastatic outgrowth in an animal model.

One potential treatment for CF is gene therapy, and a major challenge in gene therapy is packaging replacement genes so they can be delivered to the target cells.

«Investigating these pathways may identify other targets for therapy or other markers that predict treatment response,» says first author Theresa Wampler Muskardin, M.D., a rheumatologist at Mayo Clinic in Rochester, Minn. «It will help rheumatologists find the right drug for each patient and spare patients medications that won't work for them.»

«One of the challenges of current cancer therapies, including new targeted therapies, is a cancer cell's ability to overcome a treatment's anticancer properties.

By contrast, the MacLaren team's therapy targets photoreceptors that are neurons lasting for life — so in principle patients need only have the treatment once.

By targeting the fundamental DNA of the gene, the zinc finger therapy also has the advantage over other potential Huntington's therapies of needing less frequent treatments.

Nevertheless, trying to develop new therapies based on what treatments will look like in the coming decade is a nearly impossible task, points out Michael Stratton, joint head of the Cancer Genome Project and professor of cancer genetics at the University of London's Institute of Cancer Research, who has been working on developing finely targeted cancer treatments since identifying the BRAF oncogene in 2002.

Triple - negative cancers are so called because they do not express receptors for the hormones estrogen and progesterone, nor for HER2 (human epidermal growth factor 2), and hence patients with these cancers are not candidates for treatment with modern hormonal therapies or the highly effective HER2 - targeted drug Herceptin (trastuzumab).

As targeted therapies take center stage in cancer treatment, they are profoundly changing the way research is done.

«As we are entering the era where we anticipate there will be many new treatments, each targeting inflammation differently, it is also important to understand the relative efficacy of these therapies in achieving our goal of mucosal healing to appropriately position them in our treatment algorithms,» said Dr. Ashwin Ananthakrishnan, senior author of the Alimentary Pharmacology & Therapeutics review.

These genetic differences have often been blamed when chemotherapy or other treatments have been unsuccessful, as it was believed that the therapy may not have targeted all of the cells within the tumor.

A highly targeted cancer radiation therapy may offer a safe and effective treatment option for elderly pancreatic cancer patients unable to undergo surgery or combined chemotherapy and radiation therapy, according to researchers at Henry Ford Hospital in Detroit.

IGRT is the process of using frequent imaging, typically performed in the treatment room prior to radiation delivery, throughout a patient's course of radiation therapy treatment to improve localization of the target and normal structures, which allows for more precise and accurate radiation delivery.