Sentences with phrase «targeting essential genes»

«By using chloroplast transformation we generated potato plants that accumulate high amounts of long stable dsRNAs targeting essential genes in the beetle,» says Ralph Bock.

Targeting an essential gene of a crop pest can turn dsRNA into a precise and potent insecticide.

Not exact matches

Because the genes that are massively amplified in the neochromosomes are essential for the cell's survival, drugs that turn those off are an obvious target for research.

In this way, the team identified a new small protein, growth inhibitor gene product (Gp) 0.6, which specifically targets and inhibits the activity of a protein essential to bacterial cells.

«Microsatellite length and location appears to be essential for EWS / FLI to activate the oncogenic gene targets,» says Dr. Lessnick.

«Identifying targets essential to cell survival in tumor suppressor genes has long been an investigational goal with the aim of offering cancer - specific vulnerabilities for targeted therapy,» said Ronald DePinho, M.D., professor of Cancer Biology, MD Anderson president, and senior author for the Nature paper.

By searching for gene deletion patterns in cancer through a concept the investigators call «synthetic essentiality,» the team identified a synthetic essential gene known as chromatin helicase DNA - binding factor (CHD1) as a therapeutic target for prostate and breast cancers lacking a tumor suppressor gene called phosphatase and tensin homolog (PTEN).

To kill an insect, the RNAs must silence a gene essential for life, and species often share genes of such crucial importance, making it difficult to target one insect over another.

Because CRISPR will never fully be rid of off - target effects, the key question for a given therapy is not strictly how many unwanted cuts it makes, but whether it disrupts any essential genes, says Jiing - Kuan Yee, a molecular biologist at the research center City of Hope in Duarte, California.

Since proper functioning of the fat body is essential for the development of the female reproductive system after a blood meal, identifying which miRNAs are important to fat body functions, and what specific genes they target, can help design ways to manipulate the levels of microRNA or their targets, affect their interactions, disrupt mosquito reproduction, and thus prevent the spread of diseases the mosquitoes transmit.

To be most effective, DNA vaccines need to be based on the genes of the viruses present in the target population, so regular genetic diversity monitoring is essential, Dukhovlinova says.

«These sequences then become the targets for a far narrower set of follow - up gene function studies in F. graminearum by reverse genetic experimentation to pinpoint the genes essential for the disease - causing abilities of this pathogen.»

For gene editing to work, it is essential to uniquely target a single site among the 3 billion nucleotides in the haploid (single set of unpaired chromosomes) human genome.

References 46 and 47 describe gene - targeting studies of CARDIF / IPS1 / MAVS / VISA and show that this adaptor has an essential role in the cytosolic pathway of type I IFN gene induction.

Homozygous lethality of the XPCS allele is likely due to reduced levels of expression of this essential protein as a result of gene targeting (Figure 1A) rather than to the mutation itself.

Overlap — Finally, successful drug targets significantly overlap with disease genes — those in which a mutation can cause a specific disease, such as cystic fibrosis — and with essential genes, that are required for normal development.

We hypothesized that antimicrobial resistance can be reversed by targeting chromosomal non-essential genes that are not responsible for acquired resistance but essential for resistant bacteria under therapeutic concentrations of antimicrobials.

A synthetic lethal target is a gene which is essential for optimal fitness of a cancer cell with a specific mutation.