Not exact matches
«The multiple sclerosis drugs currently on the market and being tested elsewhere seek to reduce the
immune attack on
cells, but none
target neurodegeneration nor do they work to restore nerve
cell function.
The protein has long been considered too complex to
target with a drug as it also is crucial to proper
function of many
immune system
cells, not just B
cells gone bad.
By manipulating the
function of certain
immune cells, called T
cells, researchers could help restore the system's balance and create new treatments to
target these diseases.
«These results represent a significant advance in our understanding of how commensal microbes can regulate host intestinal
immune responses and suggest that the identification of downstream
targets in macrophages and dendritic
cells along the GM - CSF axis can help the rationale design of novel strategies for the treatment of IBD patients with defective GM - CSF
function,» explained Dr. Merad.
Durvalumab and tremelimumab are drugs in clinical development that block the PD - 1 / PD - L1 and CTLA - 4 pathways, respectively, and
function to restimulate the
immune system to
target tumor
cells.
«This is because the stress led to poor
function against the cancer by T -
cells, which are very important in the
immune system's control and surveillance of tumours and are a major
target in many immunotherapy treatments.»
His work has really led to this new approach of
targeting immune molecules to enhance T
cell function.»
They genetically modify
target cells such as T
cells or adult
cells to induce
immune function or pluripotency.