Sentences with phrase «targeting key molecules»

Treatment for advanced melanoma has seen success with targeted therapies — drugs that interfere with division and growth of cancer cells by targeting key molecules — especially when multiple drugs are used in combination.

By giving patients an antibody targeting a key molecule in the inflammatory pathway, investigators reduced heart disease and stroke by 15 %, they reported last week.

Not exact matches

The Company focuses on discovering and developing small molecule drugs directed against tumor and immune cell targets that control key metabolic pathways in the tumor microenvironment.

«A molecular atlas of calcific aortic valve disease: Study builds molecular networks of calcific aortic valve disease to identify key molecules and therapeutic targets for a disease that affects one in four older Americans.»

Lanza also designed the nanoparticles to carry targeting molecules that home in on and bind to cancer cells that carry the complementary receptor, like a lock and key.

Researchers at the University of Leeds have made a new synthetic anti-cancer molecule that targets two key mechanisms in the spread of malignant tumors through the body.

«This is a seminal step in identifying key pathways and molecules involved in kidney cancer so that specific therapies that target these new genes can be developed to treat this cancer.»

Draths and Frost targeted this molecule as the key to making adipic acid.

The mutations inhibited key molecules involved in insulin signaling (IIS) and the nutrient signaling pathway Target of Rapamycin (TOR).

Her group is actively working to identify new molecules key to the disease process that could become potential drug targets.

One of the key parameters in these simulation models are absolute cross sections, which give the probability of interaction between a single LEE and a target molecule.

But by eliminating the sugar molecule, the new mutation also affects «a key region in the virus that is targeted by the immune system,» Hensley adds, making the vaccine less effective.

A key finding of AIDS research is that infection begins when HIV binds to a molecule called CD4 on the target cell.

«The goal of our research is to identify key molecules that govern metastasis and use them as targets for the development of new drugs.»

«Ovarian cancer target molecule may be key to blocking its spread.»

A key problem with the current system is that companies tend to work in parallel, identifying similar or identical targets and developing their own molecules — unaware of other similar products that have already been tested and discarded.

Specific Aim 2: Having utilized mutant mice to identify the key players in AMD pathology from Specific Aim 1, we will develop and test molecules that target either the anaphylatoxins or the MAC, or both, in the context of practical therapies that can be utilized in humans.

Enhancing the stability of siRNA molecules is key to ensuring that they reach target cells intact and able to effectively carry out their function.

Our group has 3 major goals: Develop novel therapeutic approaches based on centrosomal clustering To further develop our first prototype inhibitors of centrosomal clustering preclinically and to establish a robust and specific high throughput small molecule screen Discover key events in myeloma pathogenesis To investigate the pivotal transition from the pre-malignant, asymptomatic to malignant, symptomatic stages of plasma cell dyscrasias in order to understand the pathophysiology and thereby identify novel targets Translate small molecule therapeutics from bench to clinical trials To evaluate novel agents in the preclinical setting and to initiate early phase clinical trials in hematologic malignancies with focus on multiple myeloma

Altogether, our results demonstrate that kahweol is a potent anti-angiogenic compound both in vitro and in vivo, targeting some key steps shared with tumor progression, key molecules involved in ECM remodeling (MMP - 2 and uPA), and key molecules involved in inflammation (COX - 2 and MCP - 1).

We also demonstrate the inhibitory effect of kahweol on the endothelial cell potential to remodel extracellular matrix by targeting two key molecules involved in the process, MMP - 2 and uPA.

The drug, marketed as Lucentis, targets a molecule called vascular endothelial growth factor (VEGF), a key player in the growth of blood vessels.