Sentences with phrase «targeting key proteins»

Nagoya University - led research team shows in mice the potential of a special immune cell that targets a key protein in tumor growth that helps stop brain cancer.

Not exact matches

(Reuters)- Alnylam Pharmaceuticals Inc's RNAi - based drug that targets a rare genetic disease met the main goal of a key study, in a breakthrough for the new class of medicines that works by blocking disease - causing proteins.

«Proteins that appear to have neurodevelopmental significance for human babies will be key targets for future research focused on enhancing infant formula,» Lemay said.

«Since the loop has been found to be a key segment in prion protein aggregation, this site could be targeted for the development of new therapeutics designed to block prion conversion,» said Christina Sigurdson, DVM, PhD, associate professor at UC San Diego and UC Davis and senior author of the study.

Fiers discovered a key protein on the influenza virus that could serve as a target for a universal vaccine; the drug has shown promise in an early clinical trial.

The key technological innovation that enabled this achievement was the use of monobodies - small, synthetic proteins that can be custom - designed to bind to highly specific locations on target proteins.

We designed chimeric antigen receptor (CAR) T cells that specifically target podoplanin (PDPN), a key protein for the progression of solid tumors, including GBM.»

About 15 to 20 % of breast cancers are classified as «triple negative,» so called because these tumors do not express three key proteins that are biomarkers and / or drug targets for breast cancer: the estrogen receptor, the progesterone receptor, and HER2 (a member of the epidermal growth factor receptor family).

Using the same computer - based approach, the team has now been able to target the c - FLIP (cellular FLICE [FADD - like IL - 1β - converting enzyme]- inhibitory) protein, known to play a key role in cancer stem cell maintenance and survival, described in previously published work by the Institute.

Óscar Llorca and his team have used this technique to learn about the structure and functioning of a complex system called R2TP, which is involved in various key processes for cell survival such as the activation of the kinases mTOR, ATR and ATM, proteins that are the target of various cancer drugs currently being developed.

Folded proteins tend to bind to their targets firmly, like a key in a lock, at just one or two spots, but their more stretched - out wiggly cousins are like molecular Velcro, attaching lightly at multiple locations and releasing with ease.

The first study used fruit flies as an in vivo test system to reveal new evidence about the function of a key influenza protein called NS1, which has evolved to target molecular pathways in the host.

Mayo Clinic researchers have identified that a key drug target, CDK4 / 6, regulates a cancer metastasis protein, SNAIL, and drugs that inhibit CDK 4/6 could prevent the spread of triple - negative breast cancer.

But hopes that ageing could be delayed by targeting a single gene or protein in a single molecular pathway have faded, as researchers have learned that the key pathways vary according to the animal.

«Proteins that appear to have neurodevelopmental significance for human babies will be key targets for future research focused on enhancing infant formula,» Lemay said.

Knowing that this protein could be a key target in treating pancreatic cancer, they sought to understand exactly how it works.

Currently, there are no molecularly targeted therapies aimed at triple - negative breast cancer, which is a type of cancer negative for estrogen receptor, progesterone receptor and the HER2 protein — all key targets for current therapies.

To narrow down the number of chemical compounds that could be potential drug candidates, scientists utilize computer models that can predict how a particular chemical compound might interact with a biological target of interest — for example, a key protein that might be involved with a disease process.

Bapineuzumab is an antibody that targets β amyloid, a protein fragment that accumulates in the brains of Alzheimer's patients and is widely thought to be a key culprit in the disease process.

Research led by scientists at the University of Birmingham shows more precisely how G protein - coupled receptors, which are the key target of a large number of drugs, work.

Postdoctoral fellow Aaron Gitler now is searching for the original defect that the Parkinson's protein triggers in yeast cells in hopes of identifying the underlying disease pathway and key drug targets.

Blame for treatment failures is usually attributed to so - called «cold» tumors, those that do not attract T - cell infiltration and may lack key T - cell targets — the mutated proteins known as neoantigens.

By applying the method to the peripheral membrane protein and key anti-cancer target dehydroorotate dehydrogenase (DHODH) located at the mitochondria, the team is able to obtain detailed insights into the structural relationship between membrane lipid and substrate binding to the enzyme.

Understanding these pathways, and the identification of the key proteins that control the ability of cancer cells to reprogram their metabolism through biochemical, and epigenetic or genetic alterations that make them resistant to therapies, is of paramount importance for the design of more targeted and therefore less toxic therapies.

The structures of membrane - bound BCL - 2 proteins have been long sought - after because they hold the keys for understanding the mechanistic basis of activity and for the development of selective drugs free of off - target effects.

Mechanistic target of rapamycin (mTOR) is a key regulatory protein that controls the balance between cellular anabolism and catabolism.

Scientists are claiming to have zeroed in on the culprit that makes losing weight difficult for obese people, identifying a protein that stops fat cells from burning energy which they say could become a key target in treating obesity and other metabolic conditions.

By targeting the protein made by a major disease gene, we are in a position to manipulate the key biological pathway involved in the disease.

The study notes that a key feature of the new CRISPR tool is that it uses a protein called Cpf1, more recently referred to as Cas12a, to essentially function like scissors for cutting out and inserting a targeted line of genetic code.

«Seeing the design of this key protein provides a target for a potential vaccine or even a therapeutic drug,» Smith said.

Researchers at Whitehead Institute have identified a key target protein of glucocorticoids, the drugs that are used to increase red blood cell production in patients with certain types of anemia, including those resulting from trauma, sepsis, malaria, kidney dialysis, and chemotherapy.

GSK3β, the first neighbour of β - catenin is a central, highly multi-functional protein known as a key protein difficult to inhibit without causing side effects and toxicity.41 In glioblastoma and NSCLC cancer, previous studies found that the decreased level of FRAT1 influences the GSK3β activity to phosphorylate β - catenin and by that, inhibit the WNT pathway.39, 40 The role of FRAT1 in colon cancer is less known but based on its function in other cancer types and its special influencing position in colon cancer signalling, we point out its relevance as a potential target in colon cancer therapy (Fig. 3d).

To understand the selection mechanism behind mutations, network - based studies were used to estimate the importance of a mutated protein compared to non-mutated ones in signalling and protein — protein interaction networks.10, 11,12,13 Proteins mutated in cancer were found having a high number of interacting partners (i.e., a high degree of connectivity), which indicates high local importance.10 Mutated proteins are also often found in the centre of the network, in key global positions, as quantified by the number of shortest paths passing through them if all proteins are connected with each other (i.e., they have high betweenness centrality; hereafter called betweenness).11, 12 Mutated proteins also have high clustering coefficients, which means their neighbours are also neighbours of each other.10, 13 Moreover, neighbourhood analysis of mutated proteins have been previously successfully used to predict novel cancer - related genes.14, 15 However, to the best of our knowledge, no study has concentrated particularly on the topological importance of first neighbours of mutated proteins in cancer, and their usefulness as drug targets theProteins mutated in cancer were found having a high number of interacting partners (i.e., a high degree of connectivity), which indicates high local importance.10 Mutated proteins are also often found in the centre of the network, in key global positions, as quantified by the number of shortest paths passing through them if all proteins are connected with each other (i.e., they have high betweenness centrality; hereafter called betweenness).11, 12 Mutated proteins also have high clustering coefficients, which means their neighbours are also neighbours of each other.10, 13 Moreover, neighbourhood analysis of mutated proteins have been previously successfully used to predict novel cancer - related genes.14, 15 However, to the best of our knowledge, no study has concentrated particularly on the topological importance of first neighbours of mutated proteins in cancer, and their usefulness as drug targets theproteins are also often found in the centre of the network, in key global positions, as quantified by the number of shortest paths passing through them if all proteins are connected with each other (i.e., they have high betweenness centrality; hereafter called betweenness).11, 12 Mutated proteins also have high clustering coefficients, which means their neighbours are also neighbours of each other.10, 13 Moreover, neighbourhood analysis of mutated proteins have been previously successfully used to predict novel cancer - related genes.14, 15 However, to the best of our knowledge, no study has concentrated particularly on the topological importance of first neighbours of mutated proteins in cancer, and their usefulness as drug targets theproteins are connected with each other (i.e., they have high betweenness centrality; hereafter called betweenness).11, 12 Mutated proteins also have high clustering coefficients, which means their neighbours are also neighbours of each other.10, 13 Moreover, neighbourhood analysis of mutated proteins have been previously successfully used to predict novel cancer - related genes.14, 15 However, to the best of our knowledge, no study has concentrated particularly on the topological importance of first neighbours of mutated proteins in cancer, and their usefulness as drug targets theproteins also have high clustering coefficients, which means their neighbours are also neighbours of each other.10, 13 Moreover, neighbourhood analysis of mutated proteins have been previously successfully used to predict novel cancer - related genes.14, 15 However, to the best of our knowledge, no study has concentrated particularly on the topological importance of first neighbours of mutated proteins in cancer, and their usefulness as drug targets theproteins have been previously successfully used to predict novel cancer - related genes.14, 15 However, to the best of our knowledge, no study has concentrated particularly on the topological importance of first neighbours of mutated proteins in cancer, and their usefulness as drug targets theproteins in cancer, and their usefulness as drug targets themselves.

While consuming less calories compared to what you burn might be the key to losing weight, you can specifically target fat loss by basing your diet on protein.

Major target of it is a quality protein as the key ingredient which provide your dog extra ordinary nutrition for its good health and activities.