Sentences with phrase «targeting multiple diseases»
«We felt that since we would be targeting multiple diseases, it's best done outside the university.»
http://www.sciencemag.org/ Not exact matches
Preventive effects of drinking green tea on cancer and cardiovascular disease: epidemiological evidence for multiple targeting prevention
Our key target is to produce hybrid rice with consistently high - yield heterosis (hybrid vigor), good grain quality, tolerance to key environmental stresses, multiple resistances to insect pests and diseases, and high seed production yield.
CAVD progresses rapidly through multiple, distinct stages of disease, but is general diagnosed late, making it challenging to develop targeted treatments.
«Innovative genetic, cellular techniques help identify multiple disease targets: CRISPR - Cas9 and iPSC advances hold treatment promise for schizophrenia, addiction, Zika infection and other diseases.»
«Given this mechanism, ataluren offers the potential for a new therapeutic approach for multiple nonsense mutation genetic disorders by targeting the underlying cause of the disease.»
«Many diseases, especially complex diseases, involve multiple genes, and this system could be used therapeutically to target and activate multiple genes together and rescue these disease phenotypes,» says Albert Cheng, a graduate student in the Jaenisch lab and co-author of the Cell Research paper.
So whereas these diseases produce distinct symptoms and billions of dollars have been spent researching potential drugs that target their unique molecular culprits, some scientists are placing their bets on cross-cutting approaches that might work across multiple disorders.
Our data demonstrate the feasibility of targeted gene disruption in multiple rat strains within 4 months time, paving the way to a humanized monoclonal antibody platform and additional human disease models.
«Neuroscientists are using these new gene - editing and molecular tools to develop potential therapeutic targets across multiple disease fronts.»
Biden's goal is to catalyze greater investment, coordination, and collaboration in a field marked by multiple initiatives, targeting a complex of many different diseases.
«We wanted to identify some potential therapeutic targets that are common not just to one but to multiple forms of retinitis pigmentosa at late - stage disease, when it is more likely to be clinically diagnosed in a patient population.»
Already, researchers have linked noncoding DNA to Crohn disease, heart disease, multiple sclerosis, and other disorders, suggesting that enhancers could be targets for medical manipulation.
Next steps will include engineering T cells that reliably detect multiple features on cancers such as mesothelioma and glioblastoma, allowing for more precise targeting of these diseases.
However, resistance almost always develops because tumors harbor multiple genomic defects capable of driving the disease after a targeted drug knocks down one driver.
The study is investigator led and has therefore focused on clinical need, targeting patients with progressive multiple sclerosis in whom most disability is incurred... The study also reports a predominant effect on neurodegenerative rather than inflammatory outcomes, suggesting a novel mechanism of action that might be suitable as combination treatment with immunomodulatory treatments... Further phase 3 studies to measure the effect of simvastatin on sustained disability, particularly in patients with non-relapsing secondary progressive and primary progressive multiple sclerosis, are clearly needed, but this trial represents a promising point from which to develop trials of progressive disease.»
The result is a new dual - targeting drug candidate — or, as Griffin describes, «one drug addressing multiple therapeutic indications» — that could treat both diabetes and bone disease.
The research group is now working on developing safer and smarter multitasking contrast agents, which can simultaneously record and interpret multiple biological targets, and eventually allow a better understanding of biological processes and accurate diagnosis of diseases.
Combination therapies, which target multiple alterations at the same time, may offer a better way to fight this disease.
«This study illustrates the potential of gaining fundamental insights into brain function while helping patients with debilitating diseases, and provides us with a powerful way of selecting targets based on their connectivity to other regions that can be widely applied to help guide brain stimulation therapy across multiple neurological and psychiatric disorders.»
Mutations of RGS1 are associated with several autoimmune diseases, including multiple sclerosis, and a drug targeting cell migration has been approved to treat multiple sclerosis, he notes.
«The survival benefit is clearly significant and supports future efforts to study multiple targeted therapies in earlier disease settings.
Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: treating cancer like an infectious disease.
NPT088 utilizes NeuroPhage's novel and proprietary GAIM (General Amyloid Interaction Motif) technology to simultaneously target multiple types of misfolded proteins found in many diseases of aging, including Alzheimer's and Parkinson's diseases, as well as peripheral diseases, including the systemic amyloidoses.
NeuroPhage's mission is to advance the treatment of misfolded protein diseases through GAIM therapy, simultaneously targeting multiple, toxic, misfolded proteins.
NeuroPhage is initially developing drug candidates to treat Alzheimer's and Parkinson's diseases, in which multiple misfolded proteins can exacerbate disease progression, and the Company is also targeting several rare systemic amyloidosis diseases.
One of its priorities is to develop relevant strategies to decipher multiple forms of neuromuscular diseases, identify new therapeutic targets and foster novel strategies for innovative treatments.
The broad applicability of the Proclara technology enables the company to target multiple protein misfolding diseases, including neurodegenerative diseases and several rare systemic amyloidoses.
«Through its basic research into the origins of neurological disease, Gladstone has built an impressive knowledge into potential strategies and targets for treating devastating neurological diseases, such as multiple sclerosis and Alzheimer's disease,» said Peter Høngaard Andersen, Executive Vice President of Research, H. Lundbeck A / S.
They include rheumatoid arthritis (affecting joints, such as knees), multiple sclerosis (targeting nerves and muscles), Crohn's disease (affecting the gut), psoriasis and lupus (affecting skin) and the type of diabetes that typically develops in young children.
«Our research on the role of blood proteins in brain functions has identified new targets for therapeutic intervention in multiple sclerosis and other neurological diseases,» said Dr. Akassoglou.
Such complexity is reflected by the involvement of various brain regions and multiple pathways in the etiology of neurodegenerative diseases that render single drug target approaches ineffective.
Carrier testing can be ordered in various ways, including targeted single gene disease testing, panel testing of multiple genetic diseases, or less commonly through a broad genomic test looking for genetic variants throughout the genome or exome.
The ITN will prioritize studies in a few selected autoimmune diseases, building on previous experience (e.g., systemic lupus erythematosus, ANCA - associated vasculitis, psoriasis, multiple sclerosis), prioritizing diseases with a relevant antigen (whether self or microbial in origin) that can be targeted and monitored (e.g., pemphigus, MS, ANCA - associated vasculitis), and / or diseases with accessible tissue (e.g., psoriasis, inflammatory bowel disease, pemphigus, scleroderma).
She thinks fibrinogen could be a therapeutic target for multiple sclerosis and many other neurological diseases.
The system allows for pooling and testing of multiple cell lines simultaneously, and promises to accelerate the search for targeted therapies by better representing the broad genetic diversity of disease.
Additional inhibitors targeting this pathway are under development by multiple pharmaceutical companies for this genetic disease and other conditions, including diabetic macular edema.
Dr. Falk is also PI of an NIH, pharma, and philanthropic funded translational research laboratory group at CHOP that investigates the causes and global metabolic consequences of mitochondrial disease, as well as targeted therapies, in C. elegans, zebrafish, mouse, and human tissue models of genetic - based respiratory chain dysfunction, and directs multiple clinical treatment trials in mitochondrial disease patients.
In contrast to the current drugs that target one protein or one mechanism, microRNA - based AMD therapy provides a unique «one - molecule, multiple - targets» model for disease treatment, which fits particularly well with the complex nature of AMD.
Some of these conditions are known as «autoimmune» diseases, in which an overzealous immune system overshoots its target, giving rise to illnesses such as rheumatoid arthritis and multiple sclerosis.
The Biobanco - IMM allows the study of the pathogenesis of multiple diseases with enormous impact on human health (such as neurological diseases, rheumatic disorders and cancer), improving the identification of new prognostic and diagnostic tests and new therapeutic targets.
Specifically, immune system CD4 and CD8 T - cells — which target viruses — had more disease - fighting capability «after multiple annual vaccinations» than those in people who didn't get the yearly flu shot, the investigators found.