Sentences with phrase «targeting protein coding»

In addition, profiling has been exploited to identify non-coding RNAs that may represent downstream targets of activated oncogenic pathways or that are targeting protein coding genes involved in cancer.

The main molecular alterations are represented by variations in gene expression, usually mild and with consequences for a vast number of target protein coding genes.

Not exact matches

In particular, he has focused on targeting the gene coding for flagellin protein b, or flaB, which has proved to be quite distinct from one genospecies to the next.

The genetic code also holds clues to Chlamydia's surface proteins, which Stephens says should give researchers new targets for vaccines, diagnostic tests, and drugs.

In the study, the genetic targets were messenger RNA (mRNA) that code for certain proteins known to be biomarkers for aggressive breast cancer cells.

The gene that codes for this clotting protein has a very similar sequence across many plant species, and the researchers showed that the microRNA from dodder targets regions of the gene sequence that are the most highly conserved across plants.

Extensive research has already examined the function of microRNAs, a category of small evolutionarily conserved noncoding RNAs about 22 to 24 nucleotides in length that target protein - coding genes in a sequence - specific manner.

About 50 code for proteins that appear on the surfaces of these microbial pests and could be drug targets or vaccine candidates.

If so, it could make cell fate more resilient to random mutations in a plant's genetic code, even when such changes keep some gene - regulating proteins from binding their intended DNA targets.

By acquiring sections of proteins coded by other genes, which are often the target of pathogen infection, NLRs act as an «integrated defense decoy».

TKM - 080301 targets a specific gene called polo - like kinase 1 (PLK1), which codes for a protein involved in tumor cell growth.

So - called microRNAs have been shown to target specific protein - coding RNAs for destruction or inhibition of protein synthesis.

But Yang targeted several genes that code for the protein that causes mushrooms to turn brown as they age or get bruised.

Her starting point is that many antibiotics target bacteria's» ribosomes, «the universal cellular machines that translate the genetic code into proteins.»

Until now, the vast majority of CRISPR screens have targeted protein - coding genes.

Lipschutz and others previously showed that the exocyst, a protein targeting complex, plays a crucial role in receiving these «zip - coded packages» containing ciliary proteins.

Whole - genome sequencing generates the order of all three billion chemical components in a genome, while whole - exome sequencing targets the 1 to 2 percent of a person's genome that codes for proteins.

We used custom microarrays to capture and Illumina sequence 6 Mb of targeted intronic DNA, and combined this dataset with published protein coding sequences derived from transcriptome sequencing [28]--[29].

The study notes that a key feature of the new CRISPR tool is that it uses a protein called Cpf1, more recently referred to as Cas12a, to essentially function like scissors for cutting out and inserting a targeted line of genetic code.