Sentences with phrase «targeting specific cell types»

The system, originally developed in 2007 and refined by Wall and Callaway for targeting specific cell types in 2010, uses a modified version of the rabies virus to «infect» a brain region, which in turn targets neurons that are connected to it.

Compared with other viral vehicles, the immune system tends to ignore AAV, and the carrier is able to target specific cell types in the body.

«Being able to selectively target specific cell types opens up a new world for understanding how to design therapies to treat disease,» she says.

Not exact matches

So research teams began souping up various types of immune cells and even targeting them to specific protein markers on tumors.

Researchers at Penn State have combined the two approaches by taking biodegradable polymer nanoparticles encapsulated with cancer - fighting drugs and incorporating them into immune cells to create a smart, targeted system to attack cancers of specific types.

Other researchers have already loaded hollow origami structures with drugs to target specific types of cancer cells, created DNA «robots» that walk across surfaces, and mimicked the shape of viruses.

Identifying changes in the mitochondrial DNA in PPN cholinergic neurons has the potential to allow the development of more effective treatments targeted to specific cell - types.

«Only by understanding the complexities of what happens in specific cell - types found in specific areas of the brain during this disease can targeted treatments for Parkinson's disease be produced.»

The researchers found that Zika targeted two specific cell types in mice: spermatogonia, which make sperm, and Sertoli cells, which are involved in helping sperm develop and sheltering them from the blood and immune system, building what's called the blood - testis barrier.

«Ideally, specific cell types within these circuits could be targeted in order to shift attention away from unhealthy cues such as high - calorie food cues.

Furthermore, besides offering valuable insight into the function of this novel RNA type, the researchers also believe that the findings will open new avenues for novel treatments in which cell - specific enhancer sequences can be targeted to alter gene expression.

«Understanding how Cas9 is able to locate specific 20 - base - pair target sequences within genomes that are millions to billions of base pairs long may enable improvements to gene targeting and genome editing efforts in bacteria and other types of cells,» says Doudna who holds joint appointments with Berkeley Lab's Physical Biosciences Division and UC Berkeley's Department of Molecular and Cell Biology and Department of Chemistry, and is also an investigator with the Howard Hughes Medical Institute (HHMI).

As Notch appears to use cell type - specific machinery to regulate Myc, it may be possible to target the Notch - Myc signaling path in a way that does not disrupt this path in other cell types.

«Our findings are important because knowing the location and specific cell type that require Jagged expression gives us the information we need to target therapeutics to the right place to compensate for the lack of Jagged function in Alagille syndrome,» says Dong.

Solt notes that the study strongly suggests that Th17 cells have a pathological role in the development of type 1 diabetes and use of ROR - specific synthetic compounds targeting this cell type may have potential as a preventative therapy for type 1 diabetes.

«A better understanding of the brain region and cell type - specific binding targets of Hnrnph1 will tell us more about the function of this gene and possibly identify new therapeutic strategies for minimizing risk and treating psychostimulant addiction — a disorder for which there is currently no FDA - approved drug,» explained corresponding author Camron Bryant, PhD, assistant professor of Pharmacology and Experimental Therapeutics & Psychiatry at BUSM.

«Since MCR works by targeting specific DNA sequences, in cases where diseased cells have altered DNA as in HIV - infected individuals or some types of cancer, MCR - based methods should be able to distinguish diseased from healthy cells and then be used to selectively either destroy or modify the diseased cells.»

Chemical indicators have been very powerful, but are limited in scope because they can not be targeted to specific cell types or locations within a cell.

In this edition, we're going to take a look at a very interesting tool that can be used for creating (excuse the pun) specific, targeted DNA modifications in transgenic animals, embryonic stem cells, and / or tissue - specific cell types: Cre - lox recombination.

Specific emphasis will be given to various microfluidic designs targeted for use with different cell types.

They are the only means to target and manipulate specific cell types (populations) within neuronal networks in living animals.

Luckily, different cell types tend to have different things on their surfaces, which play particular parts in their specialized roles in the tissue, so it is a matter of identifying and targeting cell - surface markers that are specific to these abnormal cell types.

September 1, 1997 Targeting gene therapy to specific cells Researchers at the University of Chicago Medical Center have developed the first practical method to restrict the activity of genes used for gene therapy to a specific cell type.

Making use of cell and animal models, my laboratory group addresses some of the fundamental questions of how ethanol exposure injures the liver, with a goal ofidentifying the individual targets of ethanol - induced injury and the specific responses of the key cell types within the liver, as well as the integrated, organismal response to this ethanol - induced injury.

«This new work is exciting, because it shows that we can directly target genes within a specific cell type, which is important for targeted therapies,» says Hedrick, a Professor in the Division of Inflammation Biology.

We have generated new genetic tools for the analysis of in vivo mast cell functions that allow for cell type - specific inactivation («knock out «-RRB- of target genes selectively in mast cells by Cre loxP - mediated recombination.

While drugs can be used to quickly block NMDA receptors throughout the brain, it is hard to target drugs to a specific cell type.

The thymus is the small organ in the lymphatic system that makes T - cells, [29] which are highly specialized immune cells that target specific types and strains of microbes, like viruses.