Sentences with phrase «targets cell surface»

D'Oro, U., Vacchio, M.S., Weissman, A.M. & Ashwell, J.D. Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation.

In a first step, the water - soluble toxin assembles at the target cell surface around this core design, which makes the cell unable to repair the damage resulting from aerolysin pore formation.

Targeting these proteins may be superior to targeting cell surface proteins because their elimination confers simultaneous insensitivity to multiple cell - surface inhibitory receptors.

One of the earliest steps in lentiviral transduction is the interaction between the viral envelop and the receptors on the target cell surface.

Not exact matches

His work indicates that this cell surface marker could serve as a target for a novel brain cancer vaccine or T - cell therapies engineered to recognize and kill tumors carrying that neoantigen.

At the end of September, the European Commission approved a marketing application for Lutathera, a radioactive molecule that targets specific receptors found on the surface of neuroendocrine tumor cells.

To target liposomes to certain tissues or cells, such as tumour cells, a specific binder of a unique protein (an antigen) on the targeted cell, known as a monoclonal antibody, must be linked to the liposome surface.

Like many drugs, beta blockers target receptors embedded in the surface of cells.

In their study, which has just been published in the journal PNAS, the researchers demonstrate that the defence protein docks on to a specific target in the nematode: a modified sugar found on the surfaces of the worm's intestinal cells but also on those of molluscs like snails.

In this study, the SIgN team discovered for the first time that the integrity of p53 affects the production of a special cell surface protein called Major Histocompatibility Complex (MHC) class I. MHC class I molecules on the cancer cell surface serve as targets for the immune system.

The drug works by targeting a protein carried on the surface of about 90 percent of AML cells.

To begin the research, the scientists screened human DIPG tumor cultures for surface molecules that could act as targets for CAR - T cells.

This affords safe passage to a theoretically unlimited selection of carriers targeting distinct cell surface receptors.»

To address this challenge, Koide, Miller and their teams designed monobodies that bound to target locations on the fluoride ion channel - specifically, two small surfaces not embedded within the cell membrane.

The mushroom - shaped protein specializes in infecting cells, first by binding a trio of sites on its head to three separate sugar molecules on the surface of targeted cells.

Other researchers have already loaded hollow origami structures with drugs to target specific types of cancer cells, created DNA «robots» that walk across surfaces, and mimicked the shape of viruses.

Although some cancers — particularly those that are rife with mutations like lung cancer or melanoma — create more tangible targets on the surface of cells for the immune system to recognize and attack, other malignancies such as prostate and pancreatic cancers have proved more intransigent.

The target Porter and June ultimately chose was CD19, a protein on the surface of B cells only, discovered by researchers at Harvard Medical School in the 1980s.

Liang Xu, Ph.D. member of the KU Cancer Center's Drug Discovery, Delivery and Experimental Therapeutics program and associate professor of molecular biosciences at KU, has discovered that targeting a cell - surface receptor called «CD44s» can block pancreatic tumor formation and recurrence after radiotherapy.

Other teams are trying to find ways of targeting the progenitor cells that give rise to the surface cells.

disruption of the cell wall barrier by reactions of chlorine with target sites on the cell surface

RAR molecules are abundant on the surface of cartilage cells, hence the positive targeted response of the drug.

For the study, Dr. Dadachova's team paired the monoclonal antibody (mAb2556) designed to target a protein expressed on the surface of HIV - infected cells with the radionuclide Bismuth - 213.

T cells are thought to be able to provide protection across different strains, says Teijaro, because the bits of influenza virus the T cells recognize do not mutate as much as the influenza surface proteins, the target of antibodies.

Nivolumab, meanwhile, is an antibody that targets a protein known as PD - 1, which is also found on the T cell surface.

In this study, we examined the effectiveness of a vaccination targeting tumors that produced IL - 15 and its cell surface receptor called IL - 15R - alpha -LRB--RRB- and examined their ability to up - regulate (or increase) immune responses to tumor antigens,» Morris says.

Because HIV uses CD4 to infect cells, the researchers used a CAR molecule that hijacks the essential interaction between HIV and the cell surface molecule CD4 to make stem cell - derived T - cells target infected cells.

In addition, exosomes are being co-opted as a treatment modality and have been modified through their parental cells to express a targeting moiety or marker tag on their surface.

Inglis attributes this success to the fact that the bacteriocin targets a receptor on the bacteria's cell surface that is essential to its survival.

Last year, she and her colleagues showed that the therapy could also be used to help halt HIV by targeting one of several viral proteins on the surface of HIV - infected cells.

It targets the CD52 glycoproteins on the surface of mature immune cells, or lymphocytes, depleting levels of the aggressive T and B cells without affecting other lymphocytes.

Once they are engineered with antibodies that bind to specific receptors on the surface of targeted cells, these nanoparticles also can, in principle, become highly specific to the disease they are designed to treat.

Current efforts are focused on identifying TB - specific surface proteins that are targeted by CD4 + and CD8 + T cells and testing them in their multi-organ computational model.

Two drug classes: adamantanes (FDA approved in 1966) and neuraminidase inhibitors (oseltamivir, FDA approved in 1999) represent two classes of drugs that target viral an ion channel and a cell surface antigen, respectively, hereby preventing or treating infection.

Then they secrete onto its surface a lethal pore - forming protein that causes the target cell to leak and die

In human medicine EGFR is frequently used as the target of cancer immunotherapy because many cancer cells bear this receptor on their surface.

Most integrin inhibitor drugs target their adhesive function and block them on the surface of the cancer cell.

A specific lung - targeting molecule is attached to the carrier's surface and the steriod, dexamethasone, an anti-inflammatory, is loaded into the nanogel, which then binds to lung endothelial cells lining the inside wall of the blood vessels where it rapidly delivers the drug.

One of the immunotherapeutic approaches that has been explored thus far relies on the use of monoclonal antibodies that specifically target a protein present on the surface of prostate cancer cells called prostate specific membrane antigen (PSMA) to elicit an anti-tumor immune response and control the cancer.

But the full potential of CARs for treating solid tumors has not been reached because they have targeted molecules found on the surface of both normal cells and cancer cells, resulting in serious side effects.

The modified T cells contain a protein known as a chimeric antigen receptor (CAR), which is designed to target the CD19 protein found on the surface of B cells, including the cancerous B cells that characterize several types of leukemia and lymphoma.

A fourth goal is to map the surface of cells with KRAS mutations because this could suggest proteins or peptides that could be targeted with antibodies or nanoparticles.

The other end, known as the constant region, binds to receptors on the surface of cells that can direct the immune system to respond in a variety of ways, all in the hopes of eliminating the target on the variable end of the antibody.

In uncircumcised men Langerhans cells — immune cells that are primary targets for HIV transmission — «are more richly concentrated near the surface of the foreskin,» says Anthony Fauci, director of the U.S. National Institute of Allergy and Infectious Diseases in Bethesda, Md..

Once activated, the circuit expresses proteins designed to direct the immune system to target the tumor cells, including surface T cell engagers, which direct T cells to kill the cells.

BV is an immunotherapy that targets CD30, a protein on the surface of some Hodgkin lymphoma cells, and delivers a potent dose of chemotherapy to destroy the cell.

The protein covers the viral surface and allows it to attach to a receptor on the surface of its target cell.

«By eliminating the expression of the IgE receptor on the surface of mast cells, we have identified an innovative and targeted approach with the potential to treat allergic inflammation in millions of patients worldwide.

The authors catalogued several co-stimulatory molecules and receptors present on the surfaces of the PD -1-responsive T cells, which possibly could be targets for drugs.

Several antibody drugs have been developed to target other receptors found on cancer - cell surfaces.