Sentences with phrase «targets mitochondrial dysfunction»

In the January Journal Club, we discussed the new drug J147 which targets mitochondrial dysfunction to potentially treat Alzheimer's and other age - related diseases.

Not exact matches

With the microRNA signatures of mitochondrial function and dysfunction in RPE cells in hand, combined with a detailed mechanistic understanding of how these microRNAs are transferred from cell to cell, we can use small interfering RNAs to target specific microRNAs and block their adverse effects on mitochondria function and their transfer to other RPE cells.

Dr. Falk is also PI of an NIH, pharma, and philanthropic funded translational research laboratory group at CHOP that investigates the causes and global metabolic consequences of mitochondrial disease, as well as targeted therapies, in C. elegans, zebrafish, mouse, and human tissue models of genetic - based respiratory chain dysfunction, and directs multiple clinical treatment trials in mitochondrial disease patients.

These findings suggest that specific MFN2 mutations cause tissue - selective mitochondrial dysfunction with increased adipocyte proliferation and survival, confirm a novel form of excess adiposity with paradoxical suppression of leptin expression, and suggest potential targeted therapies.

A customized dietary protocol, targeted supplementation, and mind - body therapies enabled my dramatic recovery, as did addressing root causes of dysfunction, including micronutrient deficiencies, heavy metal toxicity, hypothalamic - pituitary - adrenal axis dysfunction, sex hormone imbalances, dysbiosis, stealth infections, blood sugar dysregulation, and aberrant mitochondrial function.