Sentences with phrase «targets the organ of»

To induce cancer mutations, the investigators package the genes for Cas9 and the RNA guide strand into viruses called lentiviruses, which are then injected into the target organs of adult mice.

To deliver the genes for Cas9 and the RNA guide strand, the MIT team packaged them into viruses called lentiviruses, which can be injected into the target organs of adult mice.

First, despite the fact that the work of educators targets the organ of learning, the brain, most teachers and school leaders have little understanding of the architecture of the brain and how it receives, filters, and applies information.

Not exact matches

I won't reveal yet who my favorites are, but I will say that these young scientist - founders came up with very creative solutions for preventing infections in some common surgeries, tackling resistance in targeted antibody drugs, improving gene vectors for cell therapies, helping the vision - impaired «see» faces and better read their environments, imaging hard - to - see spots in the lungs and other organs, improving genetic risk analysis, and expediting the logistical operations of hospitals.

Pedophiles will target children who don't know the names of sex organs because it's a sign to them that the parents aren't willing to talk openly with their children about sex and are communicating (whether intentionally or not) that it's something to be kept secret or be ashamed about, making it more likely the child will NOT report to or tell the parent that they've been abused.

The organ donors were assigned after neurologic determination of death to either of two targeted temperatures — 34 - 35 °C (hypothermia) or 36.5 - 37.5 °C (normal body temperature).

Rutgers engineers have invented a «4D printing» method for a smart gel that could lead to the development of «living» structures in human organs and tissues, soft robots and targeted drug delivery.

«They provide unique, biocompatible platforms for wireless delivery of light to virtually any targeted organ in the body,» he said.

At final trial analysis, the relative odds of delayed organ function were reduced by 38 percent when compared to targeted temperature management at normal body temperature.

The new viral treatment targets liver fibrosis, the progressive scarring of the liver that leads to organ failure.

To test the potential benefit and safety of targeted hypothermia in donors on delayed organ function rates in the recipients of their kidneys, Niemann and his research team conducted a randomized controlled trial in two large organ donation service areas from March 2012 to October 2013.

The work, recently published in Science Magazine, reveals the details of how the malaria parasite invades its initial target organ, the liver.

Using nanoparticles designed and screened for endothelial delivery of short strands of RNA called siRNA, the researchers were able to target RNAi to endothelial cells, which form the linings of most organs.

Most cells from a foreign donor, such as in transplanted organs, are targeted by the immune system, but «this one has found a way to suppress the immune system of its hosts long enough to let it be passed along,» he says.

Because previous work in rats and monkeys has found that proteins that block the costimulatory signal can hold T cells at bay, Kim Olthoff, a transplant surgeon at the University of Pennsylvania Medical Center in Philadelphia, thought her team could achieve a targeted immune suppression by getting the transplanted organ itself — rather than proteins injected into the bloodstream — to block the costimulatory signal.

The advance, described in next month's issue of Nature Biotechnology, could lead to more accurate screening of organ donors and identification of genetic targets for new drugs.

These «nanoswimmers» cross the blood — brain barrier highly efficiently, and could lead to the development of drug delivery systems that navigate through tissues and organs to target specific sites precisely.

The two cell types are important to a broad range of organ systems in the body and play active roles in diseases that could be targets for nucleic acid therapies.

Reactivation of HBV may occur with chemotherapy, organ and tissue transplantation, High dose corticosteroids, and biologicals targeting tumor necrosis factor - alpha (TNF - α), Anti-TNF medications are used in treating rheumatic diseases, such as rheumatoid arthritis, digestive conditions that include Crohn's and colitis, and dermatologic conditions, such as psoriasis.

With millions of possible combinations, identifying the optimal nanoparticles to target each organ has been overwhelming.

But they are both treating the brain as an organ that is the target of disease.

Yet studies suggesting that astronauts who spent time in space developed diabetes - like symptoms link microgravity with metabolism and point toward the liver, the major organ of metabolism, as a possible target of the space environment.

Instead of targeting specific compounds, they can highlight any toxic chemical or mixture that disrupts a key organ or life system.

Researchers will now study how these different types of messengers develop, exactly what molecules each of them carry, and what their functions are at their target organ sites.

The researchers are now in discussions with a pharmaceutical firm about screening for drugs that might target and shut off these fibrosis - causing stem cells in cases of chronic organ disease.

The selection strategy targeted cell populations expressing the inducible endothelial cell adhesion molecules, E-selectin and VCAM - 1, and proved successful in generating microvascular endothelial cell lines from a number of different organs.

In the first half of this century the new science of experimental embryology seemed to offer the best way to study the intimate bond that interlocks the growth of the peripheral neurons and their target organs.

In addition to apparently being essential to the survival of immature sympathetic neurons NGF seems to play a vital role in guiding nerve fibers toward their corresponding target organs.

This finding implies that the tip of a growing sympathetic nerve fiber elongates along a diffusion gradient of NGF released by the target organ.

«Our finding that tumor cells secrete these three distinct nanoparticles, that then target cells in different organs reflects this important aspect of the disease.»

Pilot studies using a variety of strategies suggested that this goal could be best achieved by stimulating primary organ cell cultures with TNF - α (10 ng / ml) and targeting cells expressing the endothelial cell adhesion molecules E-selectin and VCAM - 1 through a FACS - driven strategy.

Regardless of the targeted organ for cell replacement or regeneration, the shared challenges in cell therapies for diabetes such as transplant procedure and immune rejection will be well - served by the collective expertise within CCTD.

The laboratory is now analyzing the newly developed mouse models for targeted loss of MYO5B, Rab11a and Rab11 - FIP2 in the intestines and other organs.

When this swelling occurs in the liver, the primary target of HCV, it can result in an overall fattening of the organ (called steatosis), leading years later to cirrhosis and liver failure.

Successful cell replacement depends on the ability of donor cells to differentiate into all functional cell types lost in the target organ.

By secreting SDF - 1, lymphatic vessels guide the metastasis of CXCR4 + / CD133 + melanoma cells towards target organs [40].

Neurons of the peripheral nervous system (PNS), which connect the heart, lung, gut, and other organs to the CNS, are also an important target for gene delivery, especially for the study of pain.

Intestinal function is especially important as a determinant of fly aging and mortality, and many exploratory interventions target this organ.

A recent observational study investigating sex differences in target organ damage, in insulin - resistant patients, demonstrated increased vascular and renal damage in women, who had increased intima - media thickness progression, higher numbers of vascular plaques, and reduced pulse wave velocity compared with men (321).

Major challenges in the development of drug delivery systems (DDSs) have been the short half - life... chemistry affects the PK profile and organ distribution of a gold nanoparticle - based DDS containing both a passive and active targeting moiety via... -LSB-...]

In 1994, Schreiber and co-workers discovered that the proteins FKBP12 and mTOR are the simultaneous targets of the small molecule rapamycin, now approved for use as an immunosuppressant drug given to patients after organ transplantations to help prevent rejection.

Gender differences in the progression of target organ damage in patients with increased insulin resistance: the LOD - DIABETES study

We performed histological examination of GVHD target organs (liver, lung, small intestine, and colon) and the tongue, which served as a surrogate for skin damage (37), 4 wk after transplantation.

March 13, 2000 Big city drug prevention program targets Spencer, Iowa Twelve University of Chicago medical students will immerse themselves in Spencer, Iowa, for four days, bringing with them healthy and diseased human organs to give kids an inside look at what drugs can do to the body.

«With the chicken embryo, we can look at a very wide range of developmental stages, and we can identify potential target organs.

The infiltration of Th1 and Th17 cells into GVHD target organs (liver and lung), as well as the serum level of related cytokines, also were increased in allogeneic BMT recipients.

Moreover, the infiltration of Th1 and Th17 cells into GVHD target organs, as well as the serum level of proinflammatory cytokines, were significantly decreased.

The autoimmune therapeutic area represents a broad category of human disease presentations that involve a variety of organ targets and thus presents a significant challenge with respect to the development of therapies designed to re-establish self - tolerance.

Therefore the group studies with sophisticated imaging technology in vitro and ex vivo: i) the molecular mechanism driving the migration of HIV through the intestinal epithelial barrier; ii) the cellular targets in the mucosa, in specific macrophages and DCs, to identify the possible pathways to invade the tissue and disseminate to other organs; iii) the involvement of DCs and their functional properties in mediating adaptive immune responses at mucosal level; and iv) the role of antibodies with different effector functions in changing the pathways of the virus.

These syndromes include conditions in which autoimmunity is clearly implicated as causal, in light of identification of autoantibodies to relevant autoantigens; diseases suspected to be autoimmune because of the presence of autoantibodies, although the autoreactive response has not been proven to be pathogenic and could be a consequence or marker of tissue damage; and other diseases often considered to be «autoimmune,» such as psoriasis or inflammatory bowel disease, characterized by organ - targeted inflammation but without evidence of a stimulating autoantigen.