Sentences with phrase «tau hyperphosphorylation»
Ketamine induces tau hyperphosphorylation at serine 404 in the hippocampus of neonatal rats.
http://www.littlebigcat.com/ Not exact matches
PINCH in the Cellular Stress Response to Tau - Hyperphosphorylation.
Notably, she discovered the relationship between AD and the abnormal hyperphosphorylation of tau, which opened a new area of research in neurodegeneration, especially related to AD and tauopathies.
These include insoluble extracellular plaques made of beta - amyloid peptide (Aβ); intracellular neurofibrillary tangles (NFTs) resulting from the hyperphosphorylation of tau (a microtubule - associated protein); loss of hippocampal neurons; a decrease in production of brain acetylcholine; and a marked decline in glucose usage in regions of the brain associated with memory and learning.5,11,20 - 22 All of these changes can be logically explained as the sequelae resulting from long - term dysregulation of insulin signaling and glucose metabolism.
It has to do with hyperphosphorylation of tau which, as I mentioned, is linked with the development of neurofibrillary tangles: