Sentences with word «tauopathy»

Aggregation of tau protein into intracellular deposits is a pathognomonic feature of tauopathies such as Alzheimer's disease (AD) and lowering tau is a prominent therapeutic strategy under development.

P301L transgenic (tg) mice well mimic features of human tauopathies and provide a good model for investigating the role of tau in neurodegenerative events.

Other scientists recently discovered that the Tau mutation in question could increase a person's risk of developing different tauopathies, including Alzheimer's or FTD.

Abstract: Aggregation of tau protein into intracellular deposits is a pathognomonic feature of tauopathies such as Alzheimer's disease (AD) and lowering tau is a prominent therapeutic strategy under development.

In the proposed work we will address three specific aims: How does NMNAT2 reduce toxic tau species and protect neurons against tauopathy?

Scientists are eager to assess tau therapies in PSP for a number of reasons: First, it is a pure tauopathy.

«Since both TBI and Alzheimer's share features such as neurofibrillary pathology, and a variant of the tau molecule, the Quanterix device offers opportunities to further explore tauopathy that contributes to Alzheimer's disease risk,» Dr. de Leon adds.

An example is the microtubule - associated protein (MAP) tau, which is enriched in the axon in healthy neurons and distributes to the somatodendritic compartment during a class of neurodegenerative diseases collectively called tauopathies.

The research team, led by Gladstone Investigator Yadong Huang, MD, PhD, identified an important mechanism behind tauopathies.

«So much about the mechanisms that cause tauopathies is a mystery, in part because traditional approaches — such as post-mortem brain analysis and animal models — give an incomplete picture,» explained Dr. Huang, who is also an associate professor of neurology at UCSF, with which Gladstone is affiliated.

We conclude that the ACI - 5400 antibody binds to protein Tau phosphorylated at S396 and favors a conformation that is typically present in the brain of tauopathy patients, including Alzheimer's disease.

Previously we reported the development of liposome - based vaccines and their efficacy and safety in preclinical mouse models for tauopathy.

Another important tauopathy is chronic traumatic encephalopathy (CTE), a neurodegenerative disease affecting people who have been exposed to repeated head trauma, such as professional football players and boxers.

«Targeting tau acetylation could be a new therapeutic strategy against human tauopathies, like Alzheimer's disease and FTD,» says co-senior author Eric Verdin, MD, a senior investigator at the Gladstone Institutes.

ApoE4 markedly exacerbates tau - mediated neurodegeneration in a mouse model of tauopathy.

But deposits of the tau protein in the brain are also seen in a group of less common conditions known as «tauopathies.»

Yet if you look at people who develop the clinical syndrome of dementia, especially later in life, yes, they have amyloid in the brain but they also have other pathologic entities — vascular disease; synucleinopathies [insoluble fibrils of the normally soluble protein, alpha - synuclein]; a tauopathy [which is marked by disease - inducing, insoluble tangles of another protein, tau].

We here analyzed the possible interactions among phosphorylation of tau (p - tau), spine injury, neuronal death, and sex in the P301L mouse model of tauopathy.

NeuroPhage has accumulated extensive preclinical data on this candidate, demonstrating its efficacy across disease models of Alzheimer's and Parkinson's disease, tauopathies and other related diseases characterized by aggregation of amyloid beta, tau, and alpha - synuclein proteins.

Abstract: P301L transgenic (tg) mice well mimic features of human tauopathies and provide a good model for investigating the role of tau in neurodegenerative events.

These diseases include neurodegenerative conditions, such as Alzheimer's disease (AD), Parkinson's disease (PD), tauopathies, prion protein diseases, as well as peripheral amyloidoses, such as immunoglobulin light chain amyloidosis caused by myeloma.

The patents also cover second and third generation GAIM - based therapeutic candidates currently in preclinical testing for other protein misfolding diseases of the central nervous system, including Alzheimer's, Parkinson's and tauopathies, and in peripheral amyloidoses.

Studying these models allowed us to see for the first time how a specific genetic mutation may kick start the tauopathy process.»

A group of disorders that includes both Alzheimer's and FTD, tauopathies are characterized by the abnormal accumulation of the protein Tau in neurons.

Notably, she discovered the relationship between AD and the abnormal hyperphosphorylation of tau, which opened a new area of research in neurodegeneration, especially related to AD and tauopathies.

Abnormal tau formations, known as «tauopathy,» have been associated with a number of neurodegenerative disorders.

Finally, in a mouse model of tauopathy, mice subjected to the flickering - light treatment had lower levels of tau phosphorylation associated with formation of neurotoxic tangles.

We and others have found that NMNAT2 levels are significantly reduced in CNS tissues from patients with Alzheimer's disease, tauopathies, or Parkinson's disease.

The growth of lethal tau formations, known as «tauopathy,» has been associated with many neurodegenerative disorders.

We are studying how a protein called NMNAT2 provides neuroprotection in the mammalian central nervous system with a long - term goal of developing therapies to treat neurodegenerative diseases, including Alzheimer's disease and tauopathies.

In an effort to achieve these goals, we have established interdisciplinary partnerships devoted to the study of basic biological processes and signaling pathways targeted by neurodegeneration in Alzheimer's and Parkinson's disease, tauopathies, Down syndrome, neurometabolic disease (including obesity & diabetes), motor neuron disease and traumatic brain injury.

Cecilia Ljungberg, Yousuf Ali, Jie Zhu, Chia - Shan Wu, Kazuhiro Oka, R.Grace Zhai, Hui - Chen Lu (2012) «CREB - activity and nmnat2 transcription are down - regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy», Human Mol.

The rTg4510 mouse, a model of tauopathy, overexpresses P301L mutant human Tau in the forebrain.

Sarah M. Ciupek, Jingheng Cheng, Yousuf O. Ali, Hui - Chen Lu, Daoyun Ji (2015) «Progressive functional impairments of hippocampal neurons in a tauopathy mouse model», Journal of Neuroscience 35:8118 - 31.

The rTg4510 mouse, a model of tauopathy, overexpresses P301L mutant human Tau in the forebrain under control of a tetracycline tansacting element (TET - Off).

Tauopathies are neurodegenerative disorders involving an accumulation of tau in the brain.

«The ultimate goal of our program is to develop pills that could treat and even prevent Alzheimer's disease and related disorders known as tauopathies.»