Sentences with phrase «telomerase catalytic»

This little - heralded, meticulous investigation into the effects of ablation of the telomerase catalytic subunit in mice with human - like telomeres provides us with strong reassurance that, should it prove to be the preferred approach for implementing the OncoSENS strategy, the effects of knocking out TERT would be limited to those dictated by the loss of telomere - lengthening per se, and would not lead to an unintentional loss of some essential but hitherto - unknown phsyiological function.

Research from the laboratory of Chen and his colleagues, Yinnan Chen, Joshua Podlevsky and Dhenugen Logeswaran, recently uncovered a crucial step in the telomerase catalytic cycle that limits the ability of telomerase to synthesize telomeric DNA repeats onto chromosome ends.

Toward the goal of precisely augmenting telomerase activity selectively within adult stem cells, this discovery reveals the crucial step in telomerase catalytic cycle as an important new drug target.

Thus, the proposed telomerase catalytic subunits are phylogenetically conserved and represent a deep branch in the evolution of reverse transcriptases.

Not exact matches

Catalytic protein subunits of telomerase from the ciliateEuplotes aediculatus and the yeast Saccharomyces cerevisiae contain reverse transcriptase motifs.

This model structure of the catalytic portion of telomerase shows how the TFLY motif (green) is positioned at the entry of the pocket that guides the RNA template in the interior cavity of the telomerase ring and were the active site of the enzyme if located for catalysis.

These cells were immortalized by retroviral transduction of the SV40 T antigen and Telomerase reverse transcriptase (TERT), the catalytic subunit of the telomerase complex [4], and then termed HMLE (Human Mammary with Large T Telomerase reverse transcriptase (TERT), the catalytic subunit of the telomerase complex [4], and then termed HMLE (Human Mammary with Large T telomerase complex [4], and then termed HMLE (Human Mammary with Large T and TERT).

Emmanuel Skordalakes, Ph.D., was the first to decode the structure of the catalytic portion of telomerase, the enzyme that replicates DNA at the chromosome end (telomeres).

The strongest challenge to this approach, granting the periodic replenishment of somatic stem - cell pools with autologous but OncoSENS - ready stem cells, has been the possible existence of functions of TERT (telomerase reverse transcriptase — the catalytic subunit of telomerase), other than the lengthening of telomeres itself.

Such mice have a fully functional catalytic telomerase subunits, but suffer progressive telomere shortening.