Sentences with phrase «telomerase expression»

Williams K, Seiss K, Beamon J, Pereyra F, Rosenberg ES, Walker BD, Yu XG, Lichterfeld M. Epigenetic regulation of telomerase expression in HIV -1-specific CD8 + T cells.

Lin and Artandi wondered whether they could use telomerase expression as a marker to identify the subset of cells responsible for regenerating the liver during normal turnover.

Not exact matches

Hockemeyer says that it's unlikely to be another mutation, but rather an epigenetic change that affects expression of the telomerase gene, or a change in the expression of a transcription factor or other regulatory proteins that binds to the promoter upstream of the telomerase gene.

«Telomerase is a unique protein - RNA complex where the protein subunit uses its RNA component as a template to add identical fragments of DNA to the end of chromosomes,» said Emmanuel Skordalakes, Ph.D., associate professor in the Gene Expression and Regulation program of Wistar's NCI - designated Cancer Center.

The variant lies near a gene called telomerase RNA component, or TERC, and earlier studies in animals have shown that low TERC expression is associated with shorter telomeres, and faster biological aging.

Studies have shown the modification of TERC (TElomerase RNA Component) expression may be therapeutically beneficial in DC patients.

Rao's team used various approaches, including assays of telomerase activity, measurement of cell growth, and gene expression profiling of TSY - 1 treated cells, to determine how it acts.

In telomeric DNA mutants of Tetrahymena thermophila, created by expression of a telomerase RNA with an altered template sequence, division of the germline nucleus was severely delayed or blocked in anaphase.

He studies how structural changes to chromosomes impact gene expression and cell fate with a focus telomere, telomerase, and chromosomal stability, epigenetic proteins, and the role of the SOSS complex in DNA damage repair.

We also identified a «meditation effect» within the regular meditator group, characterized by a distinct network of genes with cellular functions that may be relevant to healthy aging, and this network was associated with increased expression of a number of telomere maintenance pathway genes and an increase in measured telomerase enzymatic activity.

In addition, an inverse relationship between the expression of SA - beta - Gal activity and telomerase activity was noted in cells undergoing immortalization.

Of the two telomerase components analyzed, Tert (telomerase reverse transcriptase) expression did not show any differences between groups, but Terc (telomerase RNA component) transcription was significantly higher in the IVC testes (Fig. 2B).

In recent years, several reports (1 - 10) have emerged claiming to have uncovered such functions, but generally in vitro and in nearly all cases under unphysiologically high and / or persistent forced expression of the telomerase gene.

Expression of mTert in primary murine cells links the growth - promoting effects of telomerase to transforming growth factor - beta signaling.