Sentences with phrase «telomerase from»

Removing telomerase from every cell in our body would preempt cancer before it had a chance to get started.

Catalytic protein subunits of telomerase from the ciliateEuplotes aediculatus and the yeast Saccharomyces cerevisiae contain reverse transcriptase motifs.

Not exact matches

The grueling 18 months unearthed a gold mine: Lundblad's team found three genes that are crucial for telomerase function, results that generated a flurry of groundbreaking papers from the members of her group in 1996 and 1997.

To find out, the researchers injected a cloned telomerase gene into cultured cells from retina, skin, and blood vessels, all of which are associated with degenerative, aging - related diseases.

Sequence comparisons placed the telomerase proteins in the reverse transcriptase family but revealed hallmarks that distinguish them from retroviral and retrotransposon relatives.

Amounts of telomerase RNA increased in immortal cells derived from primary mouse fibroblasts.

I also had heard from friends that the telomerase lab directed by Carol Greider was a top place.»

With each division the telomere would shorten by a notch from whatever it had been when we took telomerase out.

I calculate death would arrive around a decade from the point when telomerase was deleted.

If cells fail to turn up telomerase, they also fail to immortalize, and eventually die from short telomeres because chromosomes stick together and then shatter when the cell divides.

The new research, which studied the immortalization process using genome - engineered cells in culture and also tracked skin cells as they progressed from a mole into a malignant melanoma, suggests that telomerase plays a more complex role in cancer.

This widespread lack of the need for telomerase is used by evolution as a key component of our defense against cancer, because having a limit to the size and renewal of telomeres prevents our cells from replicating themselves indefinitely — the crucial hallmark of cancer.

Sometimes telomerase is a good guy because it helps produce immune cells and stops telomeres from shortening, but it can also make cells immortal, which prompts them to turn malignant.

However, the researchers believe that these results are proof of concept that gene therapy is a valid strategy against aplastic anemia; this therapy could also be applied to other genes — besides from telomerase — if a causal role for those other forms of the disease was discovered.

The protein produced by this gene protects the chromosome ends of the DNA from damage, and controls telomere maintenance by the telomerase enzyme.

«Indeed, the treatment [with telomerase] significantly prevents mortality from aplastic anemia, and lengthens the telomeres in the blood and in bone marrow,» say the authors.

Research from the laboratory of Chen and his colleagues, Yinnan Chen, Joshua Podlevsky and Dhenugen Logeswaran, recently uncovered a crucial step in the telomerase catalytic cycle that limits the ability of telomerase to synthesize telomeric DNA repeats onto chromosome ends.

Greider and Ariel Avilion, a grad student working in her lab toward a Ph.D. from the State University of New York, Stony Brook, were attempting to find and isolate the gene for the RNA portion — dubbed hTR — of human telomerase.

Arsenic, the researchers found, stops a gene for an important part of the telomerase enzyme, known as the reverse transcriptase subunit, from being translated.

Dang's team traced the clumping back to malfunctions in the enzyme telomerase, which maintains the caps at the ends of the chromosomes and keeps the chromosomes apart from one another.

The limitation may be that normal cells do not produce active telomerase, which can rebuild the telomeres and keep cells from becoming senescent.

Their younger cousins recovered fine, as did older mice with telomerase intact, but more than half of the aged, telomere - depleted mice died from the treatment.

The old, telomerase - deficient mice also had weaker immune systems and had more trouble recovering from a dose of chemotherapy that killed blood cells.

Studies in the last two decades revealed that telomeres and telomerase have dual functions in suppressing and facilitating tumorigenesis: In the adult human, the activity of telomerase is mostly restricted to the stem cells and is absent from the vast majority of human cells.

However, stem cells and some cancer cells make enough telomerase to keep their telomeres from shortening, effectively stopping the aging clock and allowing a seemingly unlimited number of cell divisions.

In 2001 researchers at the biotech giant Geron Corporation isolated a molecule called TA - 65 from the herb astragalus, which they said boosted telomerase activity (its effect has not yet been evaluated in published, peer - reviewed studies).

In this report, no telomerase activity in the limbal region from Schwalbe's line to the trabecular meshwork was detected.

A different example going in opposite direction, from basic to translational, is that of the recent Nobel Prize on telomeres and telomerases.

Lanes 3 and 5 show telomerase activity in the peripheral regions of the HCEC from the 16 - and 66 - year - old donors, respectively.

Telomerase activity in candidate stem cells from fetal liver and adult bone marrow.

In the assay, cell extracted telomerase enzyme synthesizes telomere repeats of GGTTAG (enzyme product) onto an artificial substrate oligonucleotide from substrate NTPs in the reaction medium.

Methods: Human corneas with attached scleral rims were obtained from eye banks and were assayed for telomerase activity and BrdU (bromodeoxyridine) incorporation to determine, respectively, the presence of a stem - like cell marker and replicative activity.

A study conducted by California's Preventive Medicine Research Institute saw telomerase production boosted by 29 percent in 24 patients who switched from a sedentary lifestyle to one defined by exercise, healthy diet and stress management.

Our patent portfolio includes patents and applications acquired from Geron Corporation, a pioneer in the fields of pluripotent stem cells and telomerase biology and new filings on work performed at Asterias.

Our vaccines also employ the LAMP sequence, licensed from Immunomic Therapeutics, to optimize antigen presentation, increasing immune responses to telomerase.

F: Demonstrates that extensive serial dilutions of central - intermediate and peripheral area HCECs only show telomerase activity in the endothelial peripheral area as taken from mixed aged donors (21 - 52 years).

Our lab studies various aspects of chromosome biology ranging from the maintenance of chromosome ends by telomerase to meiosis, hybridization and ploidy.

«Indeed, the treatment [with telomerase] significantly prevents mortality from aplastic anaemia, and lengthens the telomeres in the blood and in bone marrow,» say the authors.

Drosophila telomeric retrotransposons derived from an ancestral element that was recruited to replace telomerase.

Telomerase beautifully illustrates that you never know where medically relevant discoveries might come from.

Through such evolutionary processes, a drug that targets telomerase could seem effective at first, only to be defeated by the cancer cell line if it can (for instance) more effectively break the drug down, or prevent the drug from entering its cells, or put out the biological equivalents of the «chaff» and flares that are used by fighter jets to ward off the targeting systems of hostile missiles.

From the same group studied above, Dr. Ornish measured the activity of an enzyme produced by genes, telomerase, believed to be involved in slowing the aging process.

Telomerase renews (elongates) the telomeres, which are responsible for the protection of human DNA from damage and cancer causing errors.