Sentences with phrase «telomerase gene»

As in the former case, after being treated with telomerase gene therapy «the telomeres in the peripheral blood in these mice also lengthened and the number of blood cells increased considerably,» write the authors.

To find out, the researchers injected a cloned telomerase gene into cultured cells from retina, skin, and blood vessels, all of which are associated with degenerative, aging - related diseases.

Representative bone marrow images of aplastic anemia (left) and cured anemia upon telomerase gene therapy (right).

Dendritic cells reconstituted with human telomerase gene induce potent cytotoxic T - cell response against different types of tumors.

Telomerase gene therapy rescues telomere length, bone marrow aplasia and survival in mice with aplastic anemia

Hockemeyer says that it's unlikely to be another mutation, but rather an epigenetic change that affects expression of the telomerase gene, or a change in the expression of a transcription factor or other regulatory proteins that binds to the promoter upstream of the telomerase gene.

Though most cancers seem to require telomerase to become immortal, only some 10 to 20 percent of cancers are known to have a single - nucleotide change in the promoter upstream of the telomerase gene.

That mutation is in a promoter, a region upstream of the telomerase gene — referred to as TERT — that regulates how much telomerase is produced.

So the molecular cause is exactly the same base pair change in a telomerase gene.

In order to achieve this, researchers rely on gene therapy: using a virus as a taxi, they introduce the telomerase gene into the bone marrow cells, which can then repair the telomeres and continue generating blood cells.

After a few weeks, they treat the animals with the telomerase gene therapy.

The researchers used mice in which the telomerase gene was eliminated; specifically in bone marrow cells.

In embryos where the telomerase gene was deleted, the telomeres of all embryos became shorter than normal.

The screen returned a number of mutations in the telomerase genes.

«We now have 35 chemicals sitting in our lab that turn on the telomerase gene,» says CEO Bill Andrews.

Looking at treatments possible in the next 5 years, I think that a treatment for senile systemic amyloidosis, telomerase gene therapy, and thymus rejuvenation, in addition to the anti-aging therapies that are already available, would be able to allow some of the supercentenarians (110 +) to be able to make it past 122.

This work, published in «Blood», was carried out by the CNIO Telomeres and Telomerase Group The treatment is based on the transport of the telomerase gene to the bone marrow cells using gene therapy, a completely new strategy in the treatment of aplastic anaemia

Representative bone marrow images of aplastic anaemia (left) and cured anaemia upon the telomerase gene therapy (right).