Sentences with phrase «telomerase inhibitor»

Blocking the enzyme causes the cancerous cells to die, so the company is working with a telomerase inhibitor, imetelstat, that it hopes will kill tumor cells while leaving healthy ones unharmed.

In the Zakian group, he focused on the PIFI gene, a telomerase inhibitor.

The underlying reason is that Geron and partner Johnson & Johnson (NYSE: JNJ) are developing a first - in - class telomerase inhibitor called imetelstat for the rare blood disorders myelodysplastic syndromes (MDS) and myelofibrosis (MF).

Not exact matches

Some would simply crank their telomerase activity up even further; some would enhance the activity of drug - metabolizing enzymes that degrade the inhibitor; still others would change their cell surface proteins in ways that would make it harder for the drug to penetrate into the cell.

Since then, his team has been creating molecular inhibitors to target the TRBD RNA - binding pockets as means to inhibit telomerase enzymatic activity.

The figure demonstrates both the existence of telomerase activity in the peripheral endothelium (but not the central endothelium) and the elimination of contamination by Taq polymerase inhibitors in some tissue samples.