Sentences with phrase «telomerase regulation»
One reason why we know little about this process of telomerase silencing is because specific telomerase regulation naturally occurs only in human cells but not in mouse cells, a widely used model organism where telomerase is active in all cell types.
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In recent years, a number of factors essential for telomerase regulation and telomere maintenance have been identified.
As a consequence, telomerase regulation and telomere shortening can not be studied in mice and must be understood in the context of a primary human cell system.
Not exact matches
«Telomerase is a unique protein - RNA complex where the protein subunit uses its RNA component as a template to add identical fragments of DNA to the end of chromosomes,» said Emmanuel Skordalakes, Ph.D., associate professor in the Gene Expression and Regulation program of Wistar's NCI - designated Cancer Center.
Understanding the regulation and limitation of the telomerase enzyme holds the promise of reversing telomere shortening and cellular aging with the potential to extend human lifespan and improve the health and wellness of elderly individuals.
Telomerase is an enzyme responsible for the production of telomeres, which play an important role in the regulation of normal cell division.
Williams K, Seiss K, Beamon J, Pereyra F, Rosenberg ES, Walker BD, Yu XG, Lichterfeld M. Epigenetic regulation of telomerase expression in HIV -1-specific CD8 + T cells.