Sentences with phrase «telomere dysfunction»
Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease.
http://www.cnilas.org/
Telomere dysfunction induces environmental defects limiting hematopoietic stem cell function and engraftment.
Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment.
Further understanding of the DNA damage checkpoints induced by telomere dysfunction during aging will lend support to develop therapeutic approaches to slow down aging process and improve old organ functions.
Titia de Lange of The Rockefeller University is honored for her studies of how telomeres shield chromosome ends and of the relationship between telomere dysfunction and cancer.
We investigated telomere dysfunction, a recently discovered biomarker of cellular senescence, and found that the number of senescent fibroblasts increases exponentially in the skin of aging baboons, reaching > 15 % of all cells in very old individuals.
Clinico - Pathological Correlation of β - Catenin and Telomere Dysfunction in Head and Neck Squamous Cell Carcinoma Patients.
Telomere dysfunction — alterations in the structure and / or functioning of telomeres — is one of the molecular mechanisms underlying a number of age - related diseases but, to date, little is known about its possible role in pathologies of the liver such as cirrhosis, hepatitis and liver cancer.
The telomere G - tail length is essential for the biological effects of telomere dysfunction in vitro.
Not exact matches
The telomere G - tail shortening might cause endothelial dysfunction and age - related white matter change.
They suggested that the telomere G - tail might be a useful marker of endothelial dysfunction, as well as stroke and dementia.
Dysfunction in telomere maintenance pathways plays an integral role in aging, cancer, and certain rare diseases such as dyskeratosis congenita (DC).
reproductive aging, oocyte dysfunction, telomeres, meiosis, stem cells, oocytes, genome integrity, stem cell biology
Studies on MLSP demonstrated replicative senescence is caused by telomere loss, and telomere loss is - not - a clock counter but rather a dysfunction marker.