Sentences with phrase «telomere length»

1.5 % The average reduction in telomere length in children who sleep one hour less per night.

In their study, the researchers first confirmed that a gene previously associated with telomere length also affected telomeres in a subset of their UK sample of more than 2,700 people.

They found a highly significant correlation between telomere length at 25 days and life span; birds with longer telomeres lived longer.

Fretts AM et al. 2016 Processed Meat, but Not Unprocessed Red Meat, Is Inversely Associated with Leukocyte Telomere Length in the Strong Heart Family Study.

They tested the samples for longer telomeres that weren't the product of a protein called telomerase, which helps maintain telomere length in healthy cells and more commonly in other cancers.

«Our findings reveal a critical role for telomere length in a mouse model of age - dependent human disease,» said first author Christina Theodoris, an MD / PhD student in the laboratory of Deepak Srivastava, MD. «This model provides a unique opportunity to dissect the mechanisms by which telomeres affect age - dependent disease and also a system to test novel therapeutics for aortic valve disease.»

In the study, they measured telomere length in white blood cells and EPA+DHA in whole blood at baseline and again 5 years later.

Her clinic was the first in North America to offer genetics testing and now tests telomere length as well.

Childhood adversities are associated with shorter telomere length at adult age both in individuals with an anxiety disorder and controls

Most of your studies look at telomere length in white - blood cells, but you've started looking at cells in saliva.

We reciprocally cross-fostered urban and rural nestling great tits (Parus major L.) to study how growing up in an urban versus rural habitat affected telomere length (TL)-- a suggested biomarker of longevity.

Her clinic is leading the way in using telomere length tests as a tool in health aging programs.

«Long telomere length associated with increased lung cancer risk: Genetic predisposition for long telomeres predicts increased lung adenocarcinoma risk.»

In the new study, published in the Journal of Clinical Investigation, the Gladstone scientists linked telomere length to risk for or resistance to these types of diseases.

Now, an article «The Latent Cytomegalovirus Decreases Telomere Length By Microcompetition» by Hanan Polansky and Adrian Javaherian, published in Open Medicine by De Gruyter Open, provides some answers to these questions.

All six studies looking specifically at LTL found reduced telomere length in persons with PTSD.

Using genome data from more than 50,000 cancer cases and 60,000 controls through the GAME - ON (Genetic Associations and Mechanisms in Oncology) network, the team compared telomere lengths with the risk of developing breast, lung, colorectal, ovarian and prostate cancers, including subtypes.

It was found that couch potatoes, even those exercising at a moderate level, had the shortest telomeres, while people who exercised at high intensities had significantly longer telomere length.

Because telomere length influences premature aging and cancer, Yildiz's findings bear long - term therapeutic implications.

The results showed that participants with lower childhood socioeconomic status — indicated by fewer years that their parents were homeowners — had shorter than average telomere length.

Led by Deliang Tang and Frederica Perera at Columbia University's Mailman School of Public Health, the research team analyzed telomere length in the umbilical cord blood of 255 newborns, about half of whom were born before the plant closure and half conceived and born after.

«Mendelian randomization is an important tool that allows us to examine telomere length without the problematic biases that come with physically measuring it,» said study author Chenan Zhang, graduate student in public health sciences at the University of Chicago.

Telomere length influences longevity in other birds as well as in humans.

His studies have mostly focused on the role of p53 and Rb / p16INK4a abnormalities, and of telomere length maintenance mechanisms (telomerase and Alternative Lengthening of Telomeres).

He then combined the data on adult telomere length with information about their health and feeding habits as babies.

«Telomere length predicts cancer risk.»

«We found that women who sat longer did not have shorter telomere length if they exercised for at least 30 minutes a day, the national recommended guideline,» said Shadyab.

Conclusion: The possibility of extending telomere length with NAD + holds out hope for slowing the aging process and improving longevity.

Telomere length also began to vary during the space period.

«Further follow - up is needed to assess the role telomere length plays in health outcomes in the context of early life exposure to air pollution.»

Dr Kappei said, «We are now actively pursuing the exact molecular mechanism through which ZBTB48 controls telomere length, and further looking into ZBTB48's role in various cancers, such as neuroblastoma, in which the gene is frequently deleted.

Erosion of telomeres has long been associated with diseases of aging, but how telomere length affects human disease has remained largely a mystery.

Meanwhile, fish oil intensified oxidation associated with ageing, lowered mitochondrial electron transport chain activity and altered the relative telomere length.

Because of this, some people regard telomere length to be the best marker of our true biological age.

To address this issue, Pierce and his colleagues used Mendelian randomization, a method which calculates telomere length based on genetic factors.

The research involved creating a score representing genetically determined telomere length, based on all the established telomere associated genes and found that this score correlated with melanoma risk.

«It is possible that the early telomere length in birds predicts the susceptibility for certain diseases and not their natural life span.»

Since these telomere - related proteins are present in mammals, her research also holds lessons about human telomere length control.

Exercise is just one of many lifestyle factors that preserve telomere length and thus slow the aging process.

Telomere research pioneer Calvin B. Harley, who co-founded Telome Health last spring with Nobel laureate Elizabeth H. Blackburn, considers telomere length «probably the best single measure of our integrated genetics, previous lifestyle and environmental exposures.»

That shrinking has led many scientists to view telomere length as a marker of biological aging, a «molecular» clock ticking off the cell's life span, as well as an indicator of overall health.

While their results shed light on the unclear role of telomeres in cancer biology, Pierce and his colleagues warn that Mendelian randomization produces estimates of causal relationships, but the estimates could be biased if the genetic variants measured in the study affect cancer risk and telomere length independently.

In the multivariate regression analysis, telomere G - tail length was independently associated with FMD values and severity of ARWMCs, whereas the total telomere length was not associated with these indicators.