Sentences with phrase «telomere loss»

In looking at telomere length, an abnormal increase in telomere loss can tell us there may possibly be an immunoproliferative disorder (the inability to handle oxidative stressors), metabolic abnormalcy, or progressive chronic disease that is present.

Studies on MLSP demonstrated replicative senescence is caused by telomere loss, and telomere loss is - not - a clock counter but rather a dysfunction marker.

«We have previously found that shag chicks that experience higher levels of stress during development have greater telomere loss.

However, chicks produced by older parents had greater telomere loss during nestling growth than chicks produced by younger parents.

There also is evidence the offspring of older parents have shorter telomeres, but it is not clear whether this is due to the offspring inheriting shorter telomeres or if their telomere loss during pre - or post-natal growth is higher.

Study results showed that chicks produced by older mothers and fathers had significantly greater telomere loss than chicks produced by younger parents, but the loss appeared to occur during nestling growth, rather than during the pre-natal period.

The results appear in «Parental age influences offspring telomere loss,» published in Functional Ecology.

The results are consistent with the hypothesis that the age of the parents influences offspring longevity, in part, through its effects on offspring telomere loss during post-natal growth.

Individuals with longer telomeres or slower rates of telomere loss have been shown to have greater longevity in a wide range of species.

Not exact matches

Telomeres provide protection to chromosomes during the replication process to prevent the loss of DNA strands.

Every time linear chromosomes are replicated during late S phase, the DNA polymerase complex is incapable of replicating all the way to the end of the chromosome; if it were not for telomeres, this would quickly result in the loss of vital genetic information, which is needed to sustain a cell's activities.

Telomeres shorten every time a cell divides, and ultimately the loss of telomeres leads to cellular senescence, where cells cease to divide, and eventually, ceTelomeres shorten every time a cell divides, and ultimately the loss of telomeres leads to cellular senescence, where cells cease to divide, and eventually, cetelomeres leads to cellular senescence, where cells cease to divide, and eventually, cell death.

So we might just be able to deal with cell loss if we had a sufficiently sophisticated program of stem cell replenishment — using cells engineered to lack the one linchpin function for cancer, namely telomere elongation.

If it weren't for telomerase, this gradual shortening would eventually lead to the complete loss of the telomeres in cells that replicate frequently during a life span, and thus the gradual erosion of the genes themselves.

They report that as the fetus mature in the womb and nears term, placenta and other related tissues also age correspondingly due to telomere fragmentation and eventual loss.

She found that ASF1 loss initiated an intra-nuclear ping - pong game: cells replicated the tag and then tossed it back and forth between different chromosomes in order to build disorganized but serviceable telomeres.

Human diseases that include dyskeratosis congenita, aplastic anemia, and idiopathic pulmonary fibrosis have been genetically linked to mutations that negatively affect telomerase activity and / or accelerate the loss of telomere length.

Just as youthful stem cells use telomerase to offset telomere length loss, cancer cells employ telomerase to maintain their aberrant and destructive growth.

«Telomeres function a bit like the plastic caps at the ends of shoelaces and protect the coding DNA from loss during cell division.

One way to keep stem cells and other cells working is to avoid the loss of telomeres capping the ends of chromosomes.

Telomeres cap the ends of chromosomes and act as protection against the loss of protein - coding DNA during cell division.

However, with each round of cell division, telomeres shorten, resulting in a gradual loss of genomic stability.

This helps support our earlier observation about DNA loss being concentrated at telomeres in the hg19 genomic background shown in Fig 4.

With each cell division the telomeres of most cells shorten and this progressive DNA loss triggers a growth arrest that prohibits the cell from dividing further.

This little - heralded, meticulous investigation into the effects of ablation of the telomerase catalytic subunit in mice with human - like telomeres provides us with strong reassurance that, should it prove to be the preferred approach for implementing the OncoSENS strategy, the effects of knocking out TERT would be limited to those dictated by the loss of telomere - lengthening per se, and would not lead to an unintentional loss of some essential but hitherto - unknown phsyiological function.

If that's not enough to get your attention, another silent and insidious problem is that you may lose bone strength and bone density when cortisol is high, [i] although this is not conclusively proven in women of all ages, [ii] nor is it absolutely clear that run - of - the - mill chronic stress is causal when it comes to bone loss (though it certainly shortens telomeres).

Filed Under: Anti-Aging, Cancer, Diabetes, Exercise, Food, General Health, Stress, Weight Loss Tagged With: dna, genes, telomeres, vitamin D

There are many lifestyle choices that can lead to an increased loss of telomere length, thus encouraging the aging process.