Sentences with phrase «telomere research»

Here is the link to a new article about telomere research in patients with prostate cancer lifestyle change and telomere length.

Scientifically speaking, there's a lot riding on telomere research, from ageing and cancer prevention to the future of cloning.

In this webinar, our experts will describe the advances in telomere research as it applies to human health and how deeper characterization of the telomerase maintenance process can uncover targets for therapies.

Several biotech companies — most prominently Geron, which first made a name for itself in telomere research — are working to develop anticancer drugs that would work by deactivating telomerase.

Telomere research pioneer Calvin B. Harley, who co-founded Telome Health last spring with Nobel laureate Elizabeth H. Blackburn, considers telomere length «probably the best single measure of our integrated genetics, previous lifestyle and environmental exposures.»

Not exact matches

Blackburn conducted research focused on mothers caring for children with autism and other chronic conditions, and found that moms who were more resilient to stress — perceiving their situation as a challenge, rather than something hopeless or overwhelming — kept their telomeres longer.

In a related development in 2008, a group of psychologists concluded in a research paper that a sense of purpose and direction prolongs life and we can see evidence of this in our DNA — specifically our telomeres.

Beginning as early as this spring, the companies will offer telomere - measurement tests to research centers and companies studying the role of telomeres in aging and disease; the general public may have access by the fall through doctors and laboratories, perhaps even directly.

Researchers from several institutions, including, UCLA, Boston University, Stanford University and the Institute for Aging Research at Hebrew SeniorLife, analyzed blood samples from nearly 10,000 people to find that genetic markers in the gene responsible for keeping telomeres (tips of chromosomes) youthfully longer, did not translate into a younger biologic age as measured by changes in proteins coating the DNA.

Although enthusiasm for the research services runs high, some telomere experts question the tests» current value for individuals.

Cech was collaborating with the younger professor on research involving telomeres, the DNA - and - protein caps that guard chromosome tips.

The most important question for people taking the telomere test, though — whether you can do anything about your shrinking telomeres, if indeed they cause disease — is the one that still needs the most research.

How much a certain change — say, running or cutting back on fat — is going to affect your telomeres, if at all, is a level of specificity that the research can't yet provide.

A research group discovered a new function of the chromosomal terminus, which may lead to the clarification of the mechanism for developing abnormal telomere structure such as multiple malformation and mental retardation.

He worked there for 3 years, continuing his research on telomeres and pioneering the microarray techniques that form the basis of his international reputation.

However, Steven Henikoff, a biochemist at Fred Hutchinson Cancer Research Center in Seattle, Washington, calls this scenario «highly improbable,» pointing out that new centromeres are evolving all the time, and not from telomeres.

It potentially also suggests applications for the human ageing process even at old age when telomere length has already decreased,» said Dr Grishma Rane, Research Fellow at CSI Singapore and co-first author of the study.

«One of our killifish mutants recapitulates, but in a rapid manner, a human disease called Dyskeratosis congenita, which is due to deficits in a complex involved in maintaining the end of chromosomes, or telomeres,» says lead author Dr. Itamar Harel, a postdoctoral research fellow in genetics.

Even chronic stress can wear away our telomeres, according to research done in the early 2000s that looked at mothers caring for children with chronic diseases.

Past research suggests a strong correlation between telomere dynamics and the processes that determine human aging and lifespan.

Was it luck that you ended up researching telomeres?

Research results from Lund University in Sweden show that urban great tits have shorter telomeres than others of their own species living in rural areas.

Additionally, current research is targeting telomere lengthening mechanisms as a cancer therapy.

The studies on autophagy by Yoshinori Ohsumi, which earned him the Nobel Prize in Medicine in 2016, and the discovery of cell cycle regulatory genes for which Leland Hartwell, Timothy Hunt and Paul Nurse received the same award in 2001, including the research of Elizabeth Blackburn, Carol Greider and Jack Szostak on telomeres, telomerase and its protective effect on the chromosomes, were all made possible thanks to yeast.

Research from other scientists at Johns Hopkins, he says, had suggested that some tumors, particularly those that affect the nervous system, have mutations in the ATRX gene, which produces proteins that appear to maintain the length of telomeres, repetitive segments of DNA on the ends of chromosomes that typically shorten each time a cell divides.

Dr Veronique Bataille, senior author of the paper and another dermatologist in the Department of Twin Research and Genetic Epidemiology said: «Longer telomeres are likely to be one factor explaining the protection against premature skin aging in individuals who previously suffered from acne.

«In patients whose telomeres were wearing away at a normal rate, statin treatment didn't make any difference,» says Leicester University cardiologist Nilesh Samani, who led the research.

While telomere shortening happens naturally with aging, researches indicate the process is accelerated by psychological and biological stress.

Brazilian scientists from the D'Or Institute of Research and Education (IDOR) and the Federal University of Minas Gerais (UFMG) found that ADHD kids and their mothers are more likely to have shorter telomeres, a hallmark of cellular aging, which is associated with increased risk for chronic diseases and conditions like diabetes, obesity and cancer.

Blasco is best known for her research on the enzymes that maintain telomeres — repetitive DNA sequences capping the chromosomes — and their role in cancer and aging.

For now, telomere assessment is strictly used for research purposes and not something that would translate into clinical practice, Christian said.

Related sites Richard Cawthon's Web site Basic introduction to telomeres and telomerase American Federation for Aging Research

Researchers from Leibniz Institute for Age Research — Fritz Lipmann Institute (Jena, Germany) now identified a crucial role of telomeres, the end structures of chromosomes, for sensing cells with a wrong chromosome number, referred to as aneuploidy.

Pathologist Hinh Ly's research has made a connection between genetic defects in telomere maintenance and bone marrow failure syndrome in human patients.

Research Interests: telomere, DNA damage, histone modification, aging, autophagy, Schizosaccharomyces pombe, Saccharomyces cerevisiae

There is a goodly amount of research and evidence for this therapy to be beneficial, but telomere dynamics in mice versus people are sufficient different to argue for caution still.

In her research, focused on exactly how telomeres provide this protection, Dr. de Lange has uncovered several important pieces of the puzzle.

One of the most promising fields of early stage cancer research, still only undertaken by a few scientific groups, is focused on interfering in telomere lengthening.

Anti-aging research has long focused on DNA structures known as telomeres, which have been directly linked to cell longevity.

In an associated press release author Dr Mark Iles summarised the research, «Telomeres have been described as being like the plastic tips on shoelaces that protect the shoelace from fraying, just as telomeres protect chromosomes from degrading or fusing to oneTelomeres have been described as being like the plastic tips on shoelaces that protect the shoelace from fraying, just as telomeres protect chromosomes from degrading or fusing to onetelomeres protect chromosomes from degrading or fusing to one another.

Another is to monitor the effects of transplanting telomerase - deficient but ex vivo telomere - extended bone marrow into late - generation, TMM - disabled mice, so as to be certain that the niche of such animals (or, by implication, aging humans) will support the homing, engraftment, and initial development and differentiation of such cells; the necessary research is underway now thanks to a SENS Foundation grant to Dr. Zhenyu Ju of the Institute of Laboratory Animal Sciences and Max - Planck - Partner - Group on Stem Cell Aging in the Chinese Academy of Medical Sciences, and research partner of prominent telomere biologist Dr. K. Lenhard Rudolph.

The research published by GenoMEL has identified inherited genes which increase melanoma risk which are pigment genes (affecting skin colour and vulnerability to sunburn), genes which are associated with having more moles (melanocytic naevi) and others associated with a part of the genetic makeup of the cell called the telomere.

The study, «Genetic determinants of telomere length and risk of common cancers: a Mendelian randomization study,» This work was supported by the Genetic Associations and Mechanisms in Oncology Network, Genetics and Epidemiology of Colorectal Cancer Consortium, the National Cancer Institute, the National Institute on Aging, the Cancer Research Foundation, the Wellcome Trust, and the National Health and Medical Research Council.

Her research focused on immunodeficiencies arising in short telomere syndromes, the most common group of premature aging disorders.

And there's currently a lot of exciting research centered around telomere length in relation to our longevity.

Recent research has shown that Astragalus may protect the telomeres from degradation.

Prior research has revealed that telomere length is closely linked to those 2 factors and it's known that exercise can suppress oxidative stress and inflammation.

I know it sounds like a late - night TV offer, with a vegetable dicer thrown in for free, but one of the most exciting areas of aging research is on the importance of the length of the tips of your chromosomes, called telomeres.

But Hatton said other research has shown that stressful life events can speed up shortening of telomeres.

As time passes, telomeres become shorter; their length is an excellent predictor of health and longevity, and a lot of research on aging focuses on how to protect them from shortening.