Because
telomeres become shorter as a cell ages, we can test the length of telomeres to gain a picture of the aging process.
If
telomeres become excessively diminished, the cell will become inflamed and eventually die.
As time passes,
telomeres become shorter; their length is an excellent predictor of health and longevity, and a lot of research on aging focuses on how to protect them from shortening.
As time passes,
telomeres become shorter, which leads to aging and chronic disease.
These telomeres become shorter every time a cell divides, which hinders their ability to ensure that the new cells are identical to the parent cells.
Over time,
the telomeres become too short for the cell to divide and they become «senescent.»
One key difference between telomeres and cassette leaders is that leaders stay intact as long as the tape does, whereas
telomeres become ever - so - slightly shorter every time the cell replicates itself or is hit by damaging agents like free radicals.
The more chronically stressed we are, the shorter
our telomeres become.
Not exact matches
Located at the ends of chromosomes,
telomeres typically shorten with each cell division, until the end of the chromosome
becomes so frayed that the cell dies.
Over time, these mobile elements accumulated and
became the
telomeres, says Villasante.
Telomerase periodically relengthens the
telomere before it
becomes critically short.
The
telomeres, therefore,
become a little bit shorter with each cell division process.
Therefore, adult stem cells
become exhausted in aged individuals due to
telomere length shortening that results in increased healing times and organ tissue degradation from inadequate cell populations.
In embryos where the telomerase gene was deleted, the
telomeres of all embryos
became shorter than normal.
The limitation may be that normal cells do not produce active telomerase, which can rebuild the
telomeres and keep cells from
becoming senescent.
Telomeres» initial length varies among individuals, but in everyone, they
become shorter over time.
Cell - culture studies show that when
telomeres can no longer shield chromosomes from damage, cells stop dividing or
become unstable.
No matter where the source of their DNA, as soon as the embryos
became hollow balls of cells, between the developmental stages known as blastocyst and morula, telomerase lengthened
telomeres to the right size.
When the
telomeres are worn away, the chromosomes
become vulnerable to mutations, possibly paving the way for age - related diseases such as atherosclerosis and certain cancers.
Telomeres — repeating DNA sequences at the ends of chromosomes that
become shorter with each cell division — have long tantalized biologists seeking to understand and control the aging process.
In cancerous cells, telomerase somehow
becomes reactivated, and the
telomeres begin growing again.
Telomeres do, however, gradually
become shorter, a process that is partly responsible for the aging process.
If
telomeres get too short, the cell can no longer divide and
becomes inactive or dies.
Thus, the possibility of premature aging in the IVC animals arises, which may
become evident in the
telomere machinery regulation, since Terc transcription was significantly higher in the IVC testes.
Shorter
telomeres have recently been linked to risk of certain cancers, and
telomeres are known to
become shorter with the accumulation of environmental insults over time.
In the year 2092, Nemo Nobody is a 118 - year - old man who finds himself as the last mortal amongst humans who have
become immortal due to scientific advances from the perpetual rejuvenation of
telomeres.