Sentences with phrase «telomeres do»

Telomeres do, however, gradually become shorter, a process that is partly responsible for the aging process.

Telomeres don't shrink significantly in healthy humans for decades due to an enzyme called telomerase, which partially repairs and lengthens them after each shortening.

Like aglets, telomeres don't last forever.

Greider pointed out in her paper that longer telomeres do not correlate with greater longevity in animals.

Not exact matches

Here are a few things Blackburn suggests anyone can do to keep their telomeres long.

Doing so keeps the telomeres found on the ends of your DNA strands long and able to protect chromosomes from deterioration.

It does that by grabbing telomeres from other chromosomes, which makes it straight and stable again.

Researchers from several institutions, including, UCLA, Boston University, Stanford University and the Institute for Aging Research at Hebrew SeniorLife, analyzed blood samples from nearly 10,000 people to find that genetic markers in the gene responsible for keeping telomeres (tips of chromosomes) youthfully longer, did not translate into a younger biologic age as measured by changes in proteins coating the DNA.

Those who exercise regularly have longer telomeres than those who do not.

«Telomere biology is one of the few fields that doesn't show a gender bias — and so, by frame of reference, it seems like it's dominated by women,» she says.

And in cancer cells, which unfortunately do not seem to age, telomere length is maintained virtually indefinitely.

If our telomeres have grown dangerously short, can we do anything to keep them from shortening further?

The most important question for people taking the telomere test, though — whether you can do anything about your shrinking telomeres, if indeed they cause disease — is the one that still needs the most research.

For instance, one small study found that people who ate healthier diets, did yoga or meditation, and exercised daily increased the activity of telomerase, which could lead to longer telomeres.

As a result, the readout of your telomere length test won't come with detailed information about what to do about it.

Telomere length does seem to be linked to life span; one key study in The Lancet found that otherwise - normal people over 60 who started out the study with short telomeres were more likely to die over the next 17 years than those with long telomeres.

One key difference between telomeres and cassette leaders is that leaders stay intact as long as the tape does, whereas telomeres become ever - so - slightly shorter every time the cell replicates itself or is hit by damaging agents like free radicals.

They might do just fine, but if there's something else going on combined with the shorter telomeres, that might be enough to kill them.

Even chronic stress can wear away our telomeres, according to research done in the early 2000s that looked at mothers caring for children with chronic diseases.

«Cells do not repair damage to DNA during mitosis because telomeres could fuse together.»

«While we don't yet know why this happens, it's so remarkable that it tells us something fundamental about telomeres and cell division.

The other weird thing was when we dampened down the level of telomerase, the cells didn't run out of telomeres.

But while throwing on AZT shortened the telomeres, it didn't kill the cancer cells.

Telomerase, the enzyme that repairs telomeres, is only active during pregnancy; i.e. healthy cells in an adult organism do not express telomerase.

People carrying the variant might further accelerate the biological aging process if they smoke, are obese or don't exercise — all of which are bad news for telomeres.

«Does starvation exert a stronger effect on telomere length in the reproductive cells of adults than in the leukocytes of children?

We'd like to think that telomere lengthening does facilitate long life, but it's probably just one factor.

Mice in which telomeres have been lengthened by gene therapy tended to live longer in some studies than mice that didn't get the treatment.

«In patients whose telomeres were wearing away at a normal rate, statin treatment didn't make any difference,» says Leicester University cardiologist Nilesh Samani, who led the research.

So how do shortened telomeres increase your risk of heart disease?

I understand your new UCSF robot, called ATLAS (the Automated Telomere Length Analysis System), is being used for that giant study, as it can measure several thousand samples a day as opposed to the hundred you could do before.

Although mother's telomeres were also shorter, they did not find any alteration in the father's telomere length.

What do the telomere lengths of white blood cells, which are dividing cells, tell us about what's happening in non-dividing cells, such as heart - muscle cells?

(Representative comment, from 2009 Nobel Laureate Elizabeth Blackburn, who originally studied telomeres using the protozoan Tetrahymena: «I urge you to make every possible effort to ensure that the proposed reorganization at NIH does not jeopardize the Tetrahymena stock center - it is a critical resource.»)

But do longer telomeres mean longer life in normal circumstances?

Without the RingoA - Cdk2 complex, the telomeres of the chromosomes do not tether to the membrane but rather float in the nucleus, leading to chaotic recombination.

The limitation may be that normal cells do not produce active telomerase, which can rebuild the telomeres and keep cells from becoming senescent.

Why do some clones still end up with short telomeres?

And those whose mothers attended college had 35 per cent longer telomeres than those who didn't, on average (PNAS, DOI: 10.1073 / pnas.1404293111).

Although results from mice can not be extrapolated directly to humans, says Jerry Shay of the University of Texas Southwestern Medical Center in Dallas, the mice «really do show that telomere erosion can lead to things we see in [elderly] humans.»

Their younger cousins recovered fine, as did older mice with telomerase intact, but more than half of the aged, telomere - depleted mice died from the treatment.

Telomere length decreased by 5 percent for each year the participants» parents did not own a home.

How does telomerase manage to bypass the protective function of telomeres?

Christopher Friesen, an author of the study from the University of Sydney, said: «We really don't know if shortened telomeres cause disease states or if they are a by - product of disease and ageing.

Furthermore, many mammals (including mice and rats) have short lives and die with long telomeres; the latter don't assure longevity.

The team found that deleting the PIN domain from Chp1 prevented heterochromatin formation at the telomeres but didn't affect formation at the centromere.

Do telomeres, the protective endcaps of the chromosomal DNA, have any connection to memory and aging?

It may be that, most likely, 5 of the therapies will impact health to nullify many disease but will not change the «aging» process (the one that is disconnected from telomeres but related with epigenetics) and 2 last therapies will be of intrinsic aging, of which one could end up not doing anything but remain a mitochondrial improvement manifesting as removal of mitopathies (such as MELAS) but would not alter the course of aging (such as the seperate epigenetic aging going on).

But he ended up winning the Prize for the telomere work that he had done earlier.

Sod2 haploinsufficiency does not accelerate aging of telomere dysfunctional mice.