Sentences with phrase «telomeres from»

Recent research has shown that Astragalus may protect the telomeres from degradation.

U. Biswas, M. Stevense, and R. Jessberger SMC1α Substitutes for Many Meiotic Functions of SMC1β but Can not Protect Telomeres from Damage.

Rai R, Chen Y, Lei M, Chang S. TRF2 - RAP1 is required to protect telomeres from engaging in homologous recombination - mediated deletions and fusions.

However, stem cells and some cancer cells make enough telomerase to keep their telomeres from shortening, effectively stopping the aging clock and allowing a seemingly unlimited number of cell divisions.

The study, published in Frontiers of Molecular Neuroscience, assessed the length of telomeres from 61 ADHD children (age 6 to 16) and their parents.

The team observed a relative scarcity of nucleosomes at telomeres from ASF1 - depleted cells, as one might expect once a histone chaperone is lost.

Sometimes telomerase is a good guy because it helps produce immune cells and stops telomeres from shortening, but it can also make cells immortal, which prompts them to turn malignant.

In that time, she has uncovered key elements in the biological machinery that prevents telomeres from shortening with each cell division.

It does that by grabbing telomeres from other chromosomes, which makes it straight and stable again.

Not exact matches

Doing so keeps the telomeres found on the ends of your DNA strands long and able to protect chromosomes from deterioration.

Telomeres are repetitive stretches of DNA that cap natural chromosome ends to protect them from being damaged or fused together during DNA replication.

Researchers from several institutions, including, UCLA, Boston University, Stanford University and the Institute for Aging Research at Hebrew SeniorLife, analyzed blood samples from nearly 10,000 people to find that genetic markers in the gene responsible for keeping telomeres (tips of chromosomes) youthfully longer, did not translate into a younger biologic age as measured by changes in proteins coating the DNA.

Blackburn and Szostak determined that it was a specific DNA sequence in the telomeres that kept chromosomes from fraying whenever they were copied when a cell splits in two.

Telomere proteins from ciliated protozoa bind to the single - stranded G - rich DNA extensions at the ends of macronuclear chromosomes.

The study «Telomere length is longer in women with late maternal age,» used data from LLFS to show that certain factors associated with the rate of aging and longevity, such as telomere length, are also associated with later maternal age at the birth of the lasTelomere length is longer in women with late maternal age,» used data from LLFS to show that certain factors associated with the rate of aging and longevity, such as telomere length, are also associated with later maternal age at the birth of the lastelomere length, are also associated with later maternal age at the birth of the last child.

With a grant from the National Institute on Aging, she launched another search for yeast strains with defective telomere maintenance, but on a far larger scale than in her postdoctoral work.

If our telomeres have grown dangerously short, can we do anything to keep them from shortening further?

The study, led by scientists from the University of Chicago, uses a novel method to measure genetic predisposition for telomere length, rather than physiological measures which are confounded by factors such as age and lifestyle.

Using genome data from more than 50,000 cancer cases and 60,000 controls through the GAME - ON (Genetic Associations and Mechanisms in Oncology) network, the team compared telomere lengths with the risk of developing breast, lung, colorectal, ovarian and prostate cancers, including subtypes.

Individuals carrying the variant had shorter telomeres, stretches of DNA at the ends of chromosomes that protect them from daily wear — and also aging

However, Steven Henikoff, a biochemist at Fred Hutchinson Cancer Research Center in Seattle, Washington, calls this scenario «highly improbable,» pointing out that new centromeres are evolving all the time, and not from telomeres.

The study assessed the number of children born to 75 women from two neighbouring indigenous rural Guatemalan communities, and their telomere lengths.

With each division the telomere would shorten by a notch from whatever it had been when we took telomerase out.

«The findings from our study validated recent findings on the telomere binding role of ZBTB48.

If cells fail to turn up telomerase, they also fail to immortalize, and eventually die from short telomeres because chromosomes stick together and then shatter when the cell divides.

Telomeres are bits of DNA that protect the ends of chromosomes from unraveling or degrading.

This widespread lack of the need for telomerase is used by evolution as a key component of our defense against cancer, because having a limit to the size and renewal of telomeres prevents our cells from replicating themselves indefinitely — the crucial hallmark of cancer.

They took DNA samples from Nicoya residents who were older than 60 to measure the length of their telomeres.

The gender division continues to widen until about age 75, when those with the blunted telomeres die from disease.

It wasn't until the late 1980s that a strong connection was made between telomeres and cellular aging, in a breakthrough that resulted from a bit of scientific serendipity.

Klingelhutz and his team immortalized immature precursor fat cells by adding in two genes from HPV (the virus that causes cervical cancer) along with a gene for part of an enzyme that controls the length of cells» telomeres — the pieces of DNA that protect chromosome tips from deterioration.

Telomeres are the caps at the end of chromosomes that keep them from shrinking when cells replicate.

Telomeres, compound structures at the end of each chromosome that protects the end of the chromosome from deterioration, are the genetic key to longevity.

The protein produced by this gene protects the chromosome ends of the DNA from damage, and controls telomere maintenance by the telomerase enzyme.

«Indeed, the treatment [with telomerase] significantly prevents mortality from aplastic anemia, and lengthens the telomeres in the blood and in bone marrow,» say the authors.

Research results from Lund University in Sweden show that urban great tits have shorter telomeres than others of their own species living in rural areas.

Biological age, Samani says, is related to the length of telomeres — stretches of DNA at the ends of chromosomes, which protect these precious packages of genes from daily wear and tear.

Therefore, adult stem cells become exhausted in aged individuals due to telomere length shortening that results in increased healing times and organ tissue degradation from inadequate cell populations.

These DNA repeats are part of the protective capping structures, termed «telomeres,» which safeguard the ends of chromosomes from unwanted and unwarranted DNA rearrangements that destabilize the genome.

A molecular biologist born in Hobart, Australia, Blackburn is best known for her 2009 Nobel Prize — winning discovery of telomeres, caps on the ends of chromosomes that protect genetic information from damage and are thought to play an important role in aging and cancer.

«In mammalian cells we have only been able to study ALT in cells derived from ALT - dependent tumors,» says Karlseder, who also employs roundworm models to test ALT - dependent telomere construction.

Telomere length varies from person to person, but is similar in siblings, suggesting it might be under some genetic control.

They found that the inactivation of POT1 caused by these mutations leads to longer and potentially unprotected telomeres, regions at the end of our chromosomes that protect chromosomes from damage.

Inflammation also erodes telomeres, the «caps» at the ends of chromosomes that protect genes from degradation, which can lead to early cell death, premature aging and even cancer.

The study, published in the Journal of Investigative Dermatology measured the length of white blood cell telomeres in 1,205 twins from the TwinsUK cohort.

Research from other scientists at Johns Hopkins, he says, had suggested that some tumors, particularly those that affect the nervous system, have mutations in the ATRX gene, which produces proteins that appear to maintain the length of telomeres, repetitive segments of DNA on the ends of chromosomes that typically shorten each time a cell divides.

One of the genes involved in telomere length was also associated with acne in a replication sample from the UK Acne Genetic study, also lead by King's scientists.

One biotechnology company executive flew from the United States to Colombia to try out her company's gene therapy for lengthening telomeres.

«Telomeres function a bit like the plastic caps at the ends of shoelaces and protect the coding DNA from loss during cell division.

Telomeres are repetitive nucleotide sequences found at the end of chromosomes which protect them from deteriorating during the process of replication.