Sentences with word «telomeric»

«To identify ALT, the gold standard is exchange of telomeric DNA from one chromosome to another,» he says.

Deletion of the fission yeastpot1 + gene has an immediate effect on chromosome stability, causing rapid loss of telomeric DNA and chromosome circularization.

Quantitative interaction screen of telomeric repeat - containing RNA reveals novel TERRA regulators.

Bradshaw PS, Stavropoulos DJ, Meyn MS. Human telomeric protein TRF2 associates with genomic double - strand breaks as an early response to DNA damage.

An inherently high stalling frequency of the S. cerevisiae telomerase may account for its in vitro properties and for the irregular telomeric sequences of this yeast.

In the clincher, Nausica Arnoult, a postdoc in the Karlseder lab and one of the study's co-authors, took advantage of a fluorescent tag that others had embedded into one chromosome's telomeric end and then used a whole chromosome imaging method called FISH to track where the tag went over time.

In telomeric DNA mutants of Tetrahymena thermophila, created by expression of a telomerase RNA with an altered template sequence, division of the germline nucleus was severely delayed or blocked in anaphase.

Our work support the idea that there are two imprinted gene domains, a more centromeric domain including KvLQT1 and p57KIP2, and a more telomeric domain including IGF2.

Telomerase synthesizes telomeric DNA repeats onto chromosome ends de novo.

These proteins affect chromatin structure, often in telomeric regions, and thereby affect transcription and silencing of various genes...

This enabled them to analyze the functioning of two proteins, namely, the mixed lineage leukemia (MLL) protein and the disruptor of telomeric silencing 1 - like (DOT1L) protein.

The telomerase activities of the yeasts Saccharomyces castellii and Saccharomyces cerevisiae — with regular and irregular telomeric sequences, respectively — have now been identified and characterized.

This is likely true for two reasons; 1) there would not have been much time for a large number of chromosomal rearrangements to occur between these early ancestral human and mouse genomes, 2) and that since divergence with the boreoeutherian ancestor the human genome has undergone only a small number of chromosomal rearrangements meaning that many human telomeric regions are ancestral [58, 73].

In my practical development as a scientist, I would name, as of fundamental importance, Dr. Bruno Amati and his team at the European Institute of Oncology in Milan, where I worked on my MSc thesis on the role of Myc in stem cell biology, and Prof. Lingner and the EPFL in Lausanne, where I was admitted for a summer school working on telomeric RNA interacting proteins.

These Pot1 (protection oftelomeres) proteins each bind the G - rich strand of their own telomeric repeat sequence, consistent with a direct role in protecting chromosome ends.

By 1985, Blackburn, who had started her own lab at UC Berkeley, and Carol Greider, a grad student in Blackburn's group, had discovered telomerase, an enzyme that synthesizes and preserves telomeric DNA.

I discovered what telomeric DNA consisted of and that it was a special form of DNA.

Thus, Taz1p appears to regulate telomeric recombination as well as telomerase activity in fission yeast.

«Telomerase has a built - in braking system to ensure precise synthesis of correct telomeric DNA repeats.

However, the activity of the telomerase enzyme is insufficient to completely restore the lost telomeric DNA repeats, nor to stop cellular aging.

This new mouse model reveals telomeric dysfunction as a potential factor in triggering these diseases.

The telomerase ribonucleoprotein has a phylogenetically divergent RNA subunit, which contains a short template for telomeric DNA synthesis.

Soon the cell becomes senescent as she loses nuclear chromosome telomeric DNA.

«They were tackling what seemed to be important problems,» says Sundquist, who while there studied telomeric DNA structures, the hairpin - shaped tails that cap chromosomes.

Drosophila telomeric retrotransposons derived from an ancestral element that was recruited to replace telomerase.

This finding and the varied number of repeats led Blackburn and Szostak to speculate that an enzyme adds telomeric sequences to chromosome ends.

The difference in LTL between the highest and lowest tertiles of vitamin D was 107 base pairs (P = 0.0009), which is equivalent to 5.0 y of telomeric aging.

The ribonucleoprotein enzyme telomerase synthesizes telomeric DNA by copying an internal RNA template sequence.

Most significantly, microscopy showed that nuclei of ASF1 - depleted cells contained aggregates of telomeric DNA, known as PML bodies.

Research from the laboratory of Chen and his colleagues, Yinnan Chen, Joshua Podlevsky and Dhenugen Logeswaran, recently uncovered a crucial step in the telomerase catalytic cycle that limits the ability of telomerase to synthesize telomeric DNA repeats onto chromosome ends.

The relationship between this biomarker, the telomeric 3» - overhang (G - tail) length, and cardiovascular risk in humans is unclear so far.

ZBTB48 binds through the last of its 11 zinc fingers directly to telomeric DNA (TTAGGG, in red) as well as subtelomeric variant repeats (TTGGG / TCAGGG, grey), which represent the protective caps at the end of chromosomes.

Scientists in the Netherlands observed that the telomeric DNA fragment would get longer and longer.

When the telomeric DNA - binding gene taz1 + is also deleted, trt1 − taz1 − survivors use the recombinational mode more frequently.

Each time the cell divides, the telomeric DNA shrinks and will eventually fail to secure the chromosome ends.

Researchers know that a protein called telomeric repeat - binding factor 2 (TRF2) is key to telomeric structural integrity due to the role it plays in forming the T - loop.

«By using different biochemical and biophysical methods, we show that specific DNA sequences from the Schizosaccharomyces pombe's ribosomal and telomeric DNA regions have a strong tendency to form G4 structures,» says Nasim Sabouri, Assistant Professor at the Department of Medical Biochemistry and Biophysics, and one of the researchers in the study.

Tankyrase binds to the telomeric protein TRF1 (telomeric repeat binding factor — 1), a negative regulator of telomere length maintenance.

ADP - ribosylation of TRF1 diminished its ability to bind to telomeric DNA in vitro, suggesting that telomere function in human cells is regulated by poly (ADP - ribosyl) ation.

For the complete replication of telomeric DNA and the functionality of telomeres, the activity of a telomere - specific DNA polymerase, the telomerase, is required.

The inactivation of KvLQT1 and p57KIP2 epigenetically in the centromeric domain is the primary cause of BWS, while LOI of IGF2 in the telomeric domain is predominantly involved in cancer.

Swapping the DNA binding domain of another telomeric protein, TRF2, with the zinc finger domains of TZAP showed that the TZAP zinc finger domains were sufficient to localize TRF2 to telomeres.

One study even found a telomeric shortening on children who were abused.