Clonal expansion capacity defines two consecutive developmental stages of long
term hematopoietic stem cells.
Grinenko T, Arndt K, Portz M, Mende N, Günther M, Cosgun KN, Alexopoulou D, Lakshmanaperumal N, Henry I, Dahl A, Waskow C Clonal expansion capacity defines two consecutive developmental stages of long -
term hematopoietic stem cells.
Not exact matches
As a result, they are currently being investigated as a cellular therapeutic for the treatment of autoimmune diseases and long -
term patient and graft survival following solid organ transplantation, and allogeneic
hematopoietic stem cell transplantation.
One promising solution to increase long -
term overall survival has been in the area of allogeneic
hematopoietic stem cell transplantation (HCST).
Further, it has remained a challenge to obtain enough
hematopoietic cells for studies on in vitro long -
term engraftment.
«I also see
hematopoietic stem cell transplantation, which is a primary concern at City of Hope, becoming a less - toxic treatment with similar or better long -
term effects,» Rosenthal added.
On long -
term monitoring, HPC - derived
hematopoietic cells remained detectable in both the allogenic and syngeneic mice, albeit declining with time.
Previously the long -
term benefits of
hematopoietic stem - cell transplantation in cerebral adrenoleukodystrophy (ALD) are thought to be mediated by donor - derived replacement of myeloid derived cells, possibly including microglial cells.