This week it was widely reported that a British Nurse, Pauline Cafferkey, who was thought to have made a full recovery from Ebola, has been taken to a hospital for a third time due to what health officials described as delayed complications from the virus — raising further questions about the long -
term impact of the disease on survivors.
In cats that respond, homeopathic approaches may help promote a faster recovery and lessen the long
term impact of the disease.
Not exact matches
Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability
of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost
of accommodating, announced increases in the build rates
of certain aircraft; 6) the effect on aircraft demand and build rates
of changing customer preferences for business aircraft, including the effect
of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result
of global economic uncertainty or otherwise; 8) the effect
of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution
of key milestones such as the receipt
of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation
of our announced acquisition
of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability
of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk
of nonpayment by such customers; 13) any adverse
impact on Boeing's and Airbus» production
of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts
of terrorism; 14) any adverse
impact on the demand for air travel or our operations from the outbreak
of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the
impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition
of Asco on favorable
terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect
of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect
of changes in tax law, such as the effect
of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations
of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect
of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability
of raw materials and purchased components; 23) our ability to recruit and retain a critical mass
of highly - skilled employees and our relationships with the unions representing many
of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment
of interest on, and principal
of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness
of any interest rate hedging programs; 28) the effectiveness
of our internal control over financial reporting; 29) the outcome or
impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition
of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result
of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks
of doing business internationally, including fluctuations in foreign current exchange rates, impositions
of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.
It's worth noting that our primary focus was on technologies that aided and improved primary care, which is about half
of the U.S. market in
terms of revenue dollars (there is no question that digital tools will successfully
impact specific acute
diseases / disorders, but it's our intuition these are best left to 100 % focused HC investors).
«We know it will have a big
impact in
terms of people with developmental
diseases that will not seek treatment until it's often too late.»
Breastfeeding has long been known to positively
impact the health and immune systems
of babies, but now new research is uncovering the power
of breastfeeding in helping to prevent long
term illnesses including asthma, allergies, celiac
disease, Type 1 diabetes and obesity.
It's not 100 percent, but it would certainly dampen any
impact a new pandemic strain would have in
terms of morbidity and mortality — meaning
disease as well as death.
«Acute repeated spikes in blood sugar that you see with each dose
of this drug have long -
term impacts — and can predispose patients to the development
of insulin - resistance Type 2 diabetes and cardiovascular
disease,» said David Wright, associate professor in the Department
of Human Health and Nutritional Sciences and corresponding author
of the paper.
«The
disease of TB is probably worse than it was decades ago in
terms of the health
impact of drug resistant strains and coinfection with HIV,» he says, «and drug resistance is now extensive.»
«Healthy gut bacterial communities are known to benefit immune regulation, metabolism and potentially even the nervous system, so if cholera or other diarrheal
diseases permanently
impact the microbiota, there could be long -
term effects on human health,» explains Regina LaRocque, MD, MPH,
of the Massachusetts General Hospital (MGH) Division
of Infectious
Diseases, co-senior author
of the paper.
The overproduction
of certain hormones results in a number
of symptoms
termed carcinoid
disease which may
impact the patients» quality
of life if not managed appropriately.»
It is difficult at this stage to foresee the full
impact of post-zygotic mutations in
terms of treatment options for
disease because the study was mainly focused on the technological aspects
of these genetic changes, the researchers say.
«Our work and that
of our colleagues on stress and CRF have been mechanistically implicated in Alzheimer's
disease, but agents that impact CRF signaling have not been carefully tested for therapeutic efficacy or long - term safety in animal models,» said the study's principal investigator and corresponding author Robert Rissman, PhD, assistant professor in the Department of Neurosciences and Biomarker Core Director for the Alzheimer's Disease Cooperative Study
disease, but agents that
impact CRF signaling have not been carefully tested for therapeutic efficacy or long -
term safety in animal models,» said the study's principal investigator and corresponding author Robert Rissman, PhD, assistant professor in the Department
of Neurosciences and Biomarker Core Director for the Alzheimer's
Disease Cooperative Study
Disease Cooperative Study (ADCS).
«We have addressed a concern in pregnant women with rheumatoid arthritis in
terms of a potential increased risk
of a negative
impact of their chronic
disease on the future health
of their offspring,» said Jølving.
An increased risk
of chronic kidney
disease, however, could make the condition one that has a more long -
term impact on an individual's health.
Understanding the long -
term impact of modifiable lifestyle factors such as exercise in adolescence is
of critical importance and can have substantial public health implications for
disease prevention over the course
of life, explained author Sarah J. Nechuta, MPH, PhD, assistant professor
of medicine at Vanderbilt Epidemiology Center and Vanderbilt - Ingram Cancer Center in Nashville, Tennessee.
It has been implicated in the decline or extinction
of up to 200 species
of frogs alone; the IUCN has declared Bd to be «the worst infectious
disease ever recorded among vertebrates in
terms of the number
of species
impacted and its propensity to drive them to extinction.»
«The high protein diet that has been used increasingly in recent years to control weight gain and obesity may have deleterious
impacts on kidney health in the long
term,» said Kalantar - Zadeh, director
of the Harold Simmons Center
of Kidney
Disease Research and Epidemiology, and chief
of the Division
of Nephrology and Hypertension, UC Irvine School
of Medicine.
«Potential long -
term negative
impact of high protein diets: Research highlights need for better nutritional management in chronic kidney
disease.»
«New approaches to understand the immunology
of graft - versus - host
disease and limit its
impact are urgently needed to improve the quality
of life for our patients and increase their long
term cancer - free survival.»
These
diseases may increase the likelihood
of other associated maladies with a detrimental long -
term impact on one's health and well - being, increased lifetime healthcare expenditures and a shorter life span, the researchers conclude.
We suggest these observations will have therapeutic implications for skeletal myopathies and systemic
diseases such as diabetes and obesity and for the aged population, in which reduced endurance
impacts mortality and activities
of daily living (57); as well as societal implications in
terms of altering athletic performance.
«We need to know if the current aggressive cost - sharing arrangements have adverse long -
term impacts on health, and perhaps paradoxically increase overall spending due to complications
of poorly controlled
disease,» Doshi said.
Speaking from temporary offices in Amman, Jordan, he told New Scientist: «In a city with a six million population we are afraid not only
of the direct
impact in
terms of wounded and dead, but also other aspects
of public health like outbreaks
of disease.»
Type 1 diabetes patients continue to deal with the daily
impact of the
disease and remain at risk for often severe long -
term complications.
These studies are
of great interest to us at the Michigan Alzheimer's
Disease Center as we consider the long -
term impact of sustained stress on family caregivers and adults living with a diagnosis
of dementia.
Health improvement (allowing to post - pone / escape the
diseases and thus live, healthier /
disease - free longer, but not above human MLSP
of around 122 years; thus these therapies do not affect epigenetic aging whatsoever, they are degenerative aging problems not regular healthy aging problem (except OncoSENS - only when you Already Have Cancer - which cancer increases epigenetic aging, but cancer removal thus does not change anything / makes no difference about what happens in the other cells / about what happens in the normal epigenetic «aging» course in Normal non-cancerous healthy cells) Although there is not such thing as «healthy aging» all aging in «unhealthy» (as seen from elders who are «healthy enough» who show much damage), it's just «tolerable / liveable» enough (in
terms of damage accumulating) that it does not affect their quality
of life (enough yet), that is «healthy aging»: ApoptoSENS - Clearing Senescent Cells (this will have great
impact to reduce
diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP)
of these senescent cells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to MLSP).
An ongoing project begun in 1985, CARDIA was designed to assess the long -
term impact of various factors on the development
of coronary artery
disease.
The brain is assumed to be a sterile organ in the absence
of disease although the
impact of immune disruption is uncertain in
terms of brain microbial diversity or quantity.
I had also been persuaded by the massive data on the
impact of a vegan diet in
terms of preventing and reversing chronic
diseases (including heart
disease, cancer, diabetes, arthritis, hypertension, and obesity).
A 2017 study evaluating the
impact of nutrition on Hashimoto's thyroiditis concluded that if you have Hashimoto's thyroiditis — whether or not you test positive for celiac
disease — you will benefit from a gluten - free diet in
terms of disease complication,
disease progression, and your symptoms.
This skin
disease can be devastating in
terms of self - esteem and confidence — its
impact is very real.
This compelling knowledge base underscores three significant, unmet needs: (1) valid and reliable biological and bio-behavioral measures (or «biomarkers»)
of «toxic stress» to identify children who are at higher risk
of chronic
disease in adulthood; (2) more effective intervention strategies to prevent, reduce, or mitigate the long -
term health consequences
of significant adversity in early childhood; and (3) biomarkers that are sensitive to change and can thus be used to assess the short -
term and medium -
term effects
of intervention strategies whose ultimate
impacts on physical and mental health may not be apparent until decades later.
Because
of the severe quality
of life
impacts of this
disease and the long -
term emotional and financial burden care for an epileptic dog can place on owners, first - step relatives (parents, offspring, and full or half siblings)
of an epileptic dog should not be bred.
The
term inflammatory bowel
disease (also known as idiopathic inflammatory bowel
disease and IBD) is not one
disease, but stands for a group
of conditions that
impact your cat's digestive system.
This cardiac certification will potentially
impact the long
term health
of dogs and cats, as well as, assisting breeders in screening for both congenital and inherited cardiac
disease which will ultimately improve diagnosis, treatment and care in the future.
Thanks so much: It's so important — in CVT training we learned a lot about dental health and the long
term impact of periodontal
disease.
Even with the negative
impacts of being a regular smoker or history
of inheritable
diseases in the family, premium costs with Reliance
term insurance cover do not rise too high.
Efficient effective integrated systems are needed to reduce the
impact of increasing chronic
disease and an aging population and these concepts can be applied for long -
term models.
Some
impacts on health outcomes may be expected in the medium
term, such as changes to the health care provided to infants and young children and reductions in communicable
diseases as a result
of improved health information and immunisation programs.