Long term high blood pressure can cause the kidneys to lose function and, of course, long
term over exposure to medications and chemicals also do damage.
Not exact matches
Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable
terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our
exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control
over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30)
exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.
From 2000 to 2007, local economies that had seen the most growth in their
exposure to competition from Chinese imports
over the preceding decade (1990 to 2000)-- that is, those in the top 25 percent of all US communities in
terms of
exposure — saw larger declines in employment.
That's according to a recent research report from BlackRock, which concluded that investors are better off hedging nearly all of their foreign currency
exposure over the long
term.
The Fund is an ideal complement to bullion for investors interested in silver;
exposure to both equities and bullion can provide better risk - adjusted returns
over the long -
term;
One of the best ways to give the money a chance to grow
over the long
term is by having an age - appropriate level of diversified
exposure to stocks — in the form of mutual funds, ETFs, or individual securities.
Given that each VIX futures contract has a constant vega
exposure of 1000, the S&P VIX Short
Term Futures Inverse Daily Index has been gradually increasing its vega
exposure over the past couple of years.
The risk
exposure to which you exposed your capital, measured not by volatility in market quotation but in the price paid relative to intrinsic value with an adjustment for the potential of wipeout, is the real secret of building wealth
over the long
term.
Uncertainty
over the direction the Federal Reserve might take on interest rates is also influencing investors to add to their short -
term municipal bond
exposure.
I'm putting together a similar self directed portfolio and although I want broad
exposure to world markets but I'm worried with the current state of the dollar that
over the long
term I'll be at risk.
I've noted before that day - to - day returns can't be controlled, so a «good day» for me is one where I take actions that I believe will produce good results
over time (such as buying high ranked candidates on short -
term weakness, selling lower ranked holding on short -
term strength, and aligning our
exposure to market fluctuations with the prevailing Market Climate).
There remains a need for future research to particularly show the effects of sustained or longer -
term exposures to food advertising and to test whether the observed increases in intake after acute
exposures are not later compensated for and, therefore, could lead to weight gain
over time (54).
It's easier and cheaper in
terms of an overall wage turnover, to keep Chamberlain, Walcott, Ramsey, Iwobi, Giroud et al as they've got players happy at the
exposure of playing for Arsenal, won't create a fuss
over money or conditions.
It is providing a foundation for better, longer -
term identification techniques that account for
exposure of oil to wind, waves, sunlight, and microbial degradation
over long times,» added Aeppli.
«Our findings suggest that
exposures that occur before the influence of a prior message «wears off» could cause the risk of smoking to accumulate
over the long
term,» Martino said.
Long -
term exposure to the pesticide
over one to two days reduced the ability of bees to fly.
«Long -
term exposure to female scents changes courtship behavior in male mice:
Over time, males lose ability to detect female scent.»
Both groups started out with scores of around 11, and were balanced in
terms of ADT
exposure; but while the yoga group's score ended up largely unchanged from baseline, the non-yoga group saw a decline
over the course of treatment.
The increased risk of further heat waves (intensive heat
over relatively short time scales) as well as
exposure to warmer temperatures
over the longer
term, suggest that recovery will depend on thermally - resistant individuals that may trade - off high temperature tolerance with other important attributes such as nutritional value or rapid growth.
There is unequivocal evidence of serious, adverse effects from
over exposure to sunlight in
terms of skin cancers and cataracts, but there is also accumulating evidence that sunlight
exposure, acting via its role in vitamin D synthesis, can protect against certain diseases.
Recently, Baccarelli et al250 have shown among 718 elderly participants in the Normative Aging Study that short -
term exposures (
over 1 to 7 days) to PM2.5 and black carbon are associated with decreased «global» DNA methylation in long interspersed nucleotide elements.
Such effects can occur years later, after just a single or short -
term exposure, or can develop
over time due to repeated
exposure to pollutants.
Long -
term harm from UV
exposure builds up
over time, which is why you probably didn't notice its effects in your 20s.
More than likely it will take numerous
exposures over time for students to cement new vocabulary
terms, concepts, and information.
For example, spending a little time every week
over the course of several months to prepare content toward developing a content - rich website that will attract hundreds of people from your target audience through search engines every day can give you amazing long -
term exposure.
This isn't necessarily a bad thing, because as I pointed out above, momentum
exposure can add to a fund's return
over the long
term.
This glide path is based on Fidelity's research and shows the funds» anticipated
exposure to equity, bond, and short -
term funds
over time.
Investors in Vanguard S&P 500 ETF are getting
exposure to 500 of the biggest and most successful businesses of our time, and chances are that these companies as a group will continue producing growing earnings and cash flows for investors
over the coming decades, no matter how tough the economic environment in the short
term.
In a 2016 essay titled Long -
Term Asset Returns, Dimson, Marsh, and Staunton showed that
over the last 115 years, currencies have jumped around a lot in relative value, but you would not have been any better off with
exposure to one currency
over another.
I'm putting together a similar self directed portfolio and although I want broad
exposure to world markets but I'm worried with the current state of the dollar that
over the long
term I'll be at risk.
For investors seeking long -
term investment returns in value - focused stocks
over the complete investment cycle (bull and bear markets combined), with added emphasis on reducing
exposure to general market fluctuations in conditions viewed by the Advisor as unfavorable to stocks.
For investors seeking long -
term investment returns in the U.S. equity market
over the complete investment cycle (bull and bear markets combined), with added emphasis on reducing
exposure to general market fluctuations in conditions viewed by the Advisor as unfavorable to stocks.
Check out «Stocks for the Long Run» for one example of the use of margin
over the long
term — there is a chart in there with recommended equity
exposures — it is interesting to note that for younger investors, the suggest allocation to stocks is greater than 100 %.
Laddering deposits by different maturity dates may also help reduce
exposure to fluctuations in interest rates
over the
term of the investment.
When you hedge foreign currency
exposure, you also give up any real interest rate differential
over the long -
term, and given the general profile of real interest rates internationally versus the U.S., fully hedging currency
exposure hasn't been a good long -
term policy.
In my own practice, I only pay a higher MER for a manager who has proven to beat the index
over the long -
term or who has experience or
exposure to an area of the global market I know little or nothing about.
Noting that NOBL is one of the firm's most popular smart beta ETFs, ProShares head of capital markets Steve Sachs says, «The idea is you're looking for S&P
exposure but you like the concept of dividend growth because we know
over the long
term dividends make up a lot of the return.»
It's important that readers understand that they will never completely eliminate risk from my investing activities, but by increasing my MoS and reducing
exposure to risk I stand a much better chance of generating consistent compounding returns
over the long -
term.
Days where there is no no significant news gives us a feel for how the large players are adjusting their
exposure; the same is true of looking at the trend
over 6 - 12 months, where the effect of short -
term news gets washed out.
I also have a position in MFC Industrial, a company with
exposure to metals and oil and gas (which, however, I will be selling shortly), a video game developer that is a net / net (Gravity Ltd.), a small position in RadioShack (made even smaller by the decline in share price
over the past 2 years), and finally a short -
term spinoff trade (Oil States International).
Given that each VIX futures contract has a constant vega
exposure of 1000, the S&P VIX Short
Term Futures Inverse Daily Index has been gradually increasing its vega
exposure over the past couple of years.
BSJI has a limited life span, and as such might not be appropriate for those looking for low maintenance bond
exposure over the long
term.
As a result, a strategy that reduces
exposure in periods when volatility is high and increases
exposure in periods when volatility is low would be more likely to outperform in risk - adjusted
terms over the long run.
The LibertyQ U.S. Large Cap Equity Index utilizes a multi-factor selection process that is designed to select equity securities from the Russell 1000 ® Index that have
exposure to four investment style - factors: quality, value, momentum and low volatility — while seeking a lower level of risk and higher risk - adjusted performance than the Russell 1000 ® Index
over the long
term.
Most stock managers do not hedge all their international currency
exposure, as research has shown currency hedging generally does not materially reduce volatility or increase returns
over the long
term for stocks.
A fund that seeks to provide long -
term total returns that outpace inflation
over a macroeconomic cycle through
exposure to inflation - related equities, inflation - linked bonds, and commodities.
During and after TBEX, we realize how successful the event has been in
terms of promotion, as the destination has achieved a lot of
exposure and coverage all
over the globe.»
For
over 12 years I've helped creative organizations meet their day to day and long
term goals, including Southern
Exposure, the National Alliance for Media Arts and Culture, and the Wexner Center for the Arts.
For
over 30 years, the team has handled cases involving allegations of personal injuries arising from acute or long -
term exposure to toxic substances.
The breast cancer findings were seen mostly in postmenopausal women, with a 17 percent higher risk for those who had had low
exposure, a 19 percent increased risk for those with medium
exposure and a 26 percent increased risk for those who had high long -
term exposure over their lifetime.