Sentences with phrase «termination codons»
Termination codons are small sequences of genetic code found in our DNA that tell our cells when to stop making a specific protein. They act like a "stop" sign, indicating the end of protein production. When the cell encounters a termination codon, it knows to finish building the protein and stop the process. Full definition
The mutation is a G → A substitution at c. 1473 + 1, which destroys a splice donor recognition site in intron 10 and causes exon skipping that results in a frameshift and the introduction of a premature termination codon [129].
cgejournal.biomedcentral.com
Conversely, an earlier age at breast cancer diagnosis was associated with nonpremature termination codon mutations and the founder mutations (Table 3).
A T to C transition in exon 11 replaces the opal termination codon in the C57BL / 6J allele with an arginine codon in the BALB / cBy allele.
It is a single - point deletion (c. 1623delG, p.P541fsX597) that results in creation of premature termination codon (Farias et al. 2011).
Mutations conferring NMD or premature termination codon were associated with a later age at breast cancer diagnosis.
Premature termination codon (PTC) mutations in the ATP - Binding Cassette, Sub-Family A, Member 7 gene (ABCA7) have recently been identified as intermediate - to - high penetrant risk factor for late - onset Alzheimer's disease (LOAD).