Sentences with phrase «test cell produces»

Not exact matches

Also there is evidence of molecular mechanisms in the cell membranes that can amplify small changes in the field to produce large changes in neural activity.13 On the other hand, earlier tests of Kohler's theory found that interference with electrical gradients over the cortex had no effect on behavioral measures (see note 11 for reference to these studies).

Either approach could produce enough HSCs to transplant and — pending further safety testing — potentially treat leukemia, sickle cell disease and other severe blood disorders.

The team tested whether overexpression of PGC1 - alpha could protect cultures of rat brain cells from the pesticide rotenone, which inhibits complex I of the electron transport chain in neuronal mitochondria and produces many symptoms similar to those of Parkinson's.

In lab tests, they show that one such particle can be produced in plants and it ferries small molecules to cancer cells.

Dr Coleman and her group have developed a sensitive test to allow them to detect the location and number of the stem cells after they've been added; they report that the stem cells do not permanently integrate into the host tissue but instead produce signals that encourage the host's own cells to heal the fracture more efficiently.

The enzyme was tested in three different cell lineages: leukemia cells incapable of producing asparagine at normal levels (MOLT4); another line of leukemia cells, in this case capable of producing asparagine at normal levels (REH); and non-malignant cells, used as a control (HUVECs).

Then, they produced the hemagglutanin with different combinations of these mutations in an experimental cell line (testing the mutations in H7N9 viruses themselves could be dangerous).

The researchers also tested a Runx2 knock - down variant of a human multiple myeloma cell line and found that it produced significantly less tumor growth in immunodeficient mice than the original human multiple myeloma cells.

In test tubes, this gene caused the cells to produce extra amounts of a chaperone molecule that ordinarily helps a cell recognize misfolded proteins.

Tissue engineers have been unable to grow epidermis with the functional barrier needed for drug testing, and have been further limited in producing an in vitro (lab) model for large - scale drug screening by the number of cells that can be grown from a single skin biopsy sample.

But fetal tissue is scarce, and research in the past several years suggests that stem cells, which can be mass produced in a test tube, can also replace damaged brain tissue.

In cell - based tests, Banfi and his colleagues showed that Noxo1 and Nox3 work together to produce superoxide, a precursor of oxygen free radicals.

In test - tube experiments with hamster cells, the DNA vaccine created mRNA that both copied itself like it would in the alphavirus and produced antigen.

The researchers then tested the particles» ability to shut off the gene for a blood clotting protein called Factor VII, which is produced in the liver by cells called hepatocytes.

The researchers tested two anti-CK2 drugs for their ability to stimulate the production of new brown fat in mice: a new small - molecule CK2 - blocker called silmitasertib (CX - 4945), which is already in clinical trials as a cancer therapeutic; and a more precise next - generation antisense oligonucleotide (ASO) drug developed in collaboration with Isis Pharmaceuticals, which eliminates CK2 by blocking the RNA instructions cells use to produce it.

Bone marrow biopsies often produce limited numbers of tumor cells to test — as few as 50,000 tumor cells in this study — but for this technique that is enough to test many different drugs and drug combinations.

As well as the potential to produce pigment - correct skin grafts, the team's 3D bioprinting method could also be used to develop skin constructs for toxicology testing and fundamental cell biology research.

An older strategy, «phenotypic» screening, avoids much of this problem by testing compounds for their ability to produce a desired effect directly on living cells.

Further tests suggested that epithelial cell progenitors helped by restoring the connection between cells called myoepithelial contractile cells and the lacrimal gland's secretory cells, which produce tears.

The Münster immunologists found a test - tube alternative for this, too: they used the molecular biological method of genome editing to systematically «cut out» the gene segment relevant for VLA4 and produce the appropriate «deficient» immune cells.

The real test will be in getting the stem cells produced by StemBANCC into the hands of researchers in a way that actually does this.

The Stanford team tested their technology on a custom - made solar absorber — a device that mimics the properties of a solar cell without producing electricity — covered with a micron - scale pattern designed to maximize the capability to dump heat, in the form of infrared light, into space.

Georgia Tech's Rohatgi has been testing SiXtron's machine versus conventional silane solar cell production and found that they produce similar quality cells.

Garle and his colleagues have designed a test that measures levels of a chemical to show the «sum effect» of all the cytokines produced by the skin cells.

They sent soil samples for DNA testing, looking for matches with particular genes known to be found in microbes and fungi; they tried to stimulate microbial growth on a wide variety of substances and then count the cells produced; and they used highly sensitive radiorespiration activity assays, which involve feeding the soil microorganisms a food source which has been labelled with radioactive carbon, which can then be used to detect if the microorganisms are active.

Electricity produced by a fuel cell by combining hydrogen and oxygen powered an electric motor to turn the two - seat test glider's propeller and enabled it to fly for roughly 20 minutes at 62 miles per hour (100 kilometers per hour) at about 3,300 feet (1,000 meters) above sea level.

Testing many variants, the team eventually found an artificial receptor design that worked well in cell culture, enabling host T cells to efficiently destroy cells producing antibodies to desmoglein, including those derived from PV patients.

The ultimate test of a stem cell is its ability to produce different cell types.

Therefore, those were chosen to test whether the molecules produced by the neural stem cells of patients alter the angiogenic capacity of the cells.

To test the quality of the «blood vessels» produced, the researchers cultured a chunk of tissue made from rat liver cells using their technique.

Graduate student Yu - Hsiang Tu then tested candidate genes one - by - one until he found one that produced a proton - conducting protein when introduced into cells that did not have any proton - conducting channels.

Research has suggested that standard therapies combined with drugs that inhibit PARP1 can kill cancer cells, but clinical trials testing PARP1 inhibitors in cancer patients have produced disappointing outcomes.

He says devices like this are already being tested for their ability to house insulin - producing cells derived from stem cells.

First, we produced PARP1 - KO ovarian cancer cell lines using CRISPR / Cas9 gene editing to test the loss of PARP - 1 as a resistance mechanism to all clinically used PARP inhibitors.

In addition, Celvive has partnered with a US - based FDA - approved manufacturer to produce the StemCure ™ cell isolation and delivery system which has been tested to prepare for an IND application with the FDA for the second phase of clinical studies in the US.

This requires the intervention of sophisticated robotic technology to produce the required quantities of cells on one hand, to practice drug tests under conditions to identify the compound effective to thousands of thousands of others, on the other hand.

ViaCyte is aiming to eliminate rigorous insulin treatment and glucose testing by engineering a type of stem cell that produces insulin and other hormones that regulate sugar levels.

Overall, this simple technique (see figure for overview) produces therapeutically relevant cells in a safe and efficacious manner, which may be used in in vitro models for the investigation of glaucoma disease mechanisms, RGC development, drug testing, and may in the future lead to a treatment of glaucomatous neuropathy.

The piece mentioned that some of the funds would support ViaCyte and our efforts to develop and test the VC - 01 ™ product, comprised of an implantable device that holds precursor cells that upon implant in a patient are expected to differentiate to become pancreatic islet cells that produce insulin and other blood sugar - regulating hormones.

The numbers of cells produced in StemSpan ™ SFEM II were significantly higher than in all other media (* p < 0.01, paired t - test, n = 6).

To test whether GBP1 and GBP2 transmit nutritional information from the fat body to the insulin - producing cells, we determined whether GBP1 and GBP2 control ILP secretion.

Specifically, 8.0 ± 5.8 % of the SC area of cell - injected eyes produced thresholds less than 0.8 log units, 22.0 ± 8.5 % produced thresholds less than 1.5 log units and 67.7 ± 10.0 % yielded thresholds less than 2.1 log units, with best test points falling within the normal, non-dystrophic range.

There may also be a blood test for a substance produced by some cancer cells called carcinoembryonic antigen (CEA).

In one test, the scientists controlled the cell's ability to produce acetate.

In two new publications in the journal Molecular Therapy, University of Cincinnati (UC) biomedical engineering professor Peixuan Guo, PhD, details successful methods of producing large RNA nanoparticles and testing their safety in the delivery of therapeutics to targeted cells.

Now, ViaCyte is testing the VC - 01 ™ product candidate made up of macro-encapsulated pancreatic progenitor cells, precursor cells that are expected to differentiate into mature cells that produce insulin and other hormones.

The VC - 01 product candidate is the first embryonic stem cell - derived islet replacement therapy to reach clinical testing and is currently being evaluated in patients with T1D who have minimal to no insulin - producing beta cell function.

Excitingly, because stem cells can produce such large numbers of neurons, we can even test for and identify new drug candidates using patient specific neurons.

The oxygen carrying capacity of these blood cells can be tested under varying temperatures and stress conditions without ever producing an animal.

We therefore tested whether both the αβ and γδ subsets of IL7RαhiCcr6 + T cells produce IL17 in skin draining LNs following bacterial or fungal challenge.