Sentences with phrase «test compound»

Three - dimensional skin models offer the potential to study various diseases and test compounds in vitro.

These are well tested compounds, and there have been few cases of adverse skin reactions, from what I've read.

To determine the ability of test compounds to activate HMOX E2 - dependent expression in the presence of Bach1, cells were treated with CoPP, CDDO - Me, or HPP - 4382.

An older strategy, «phenotypic» screening, avoids much of this problem by testing compounds for their ability to produce a desired effect directly on living cells.

In an effort to block Aire and prevent the immune system from killing off T - cells that might recognize melanoma, researchers tested a compound, an anti-RANKL antibody in mice.

The study's original aim was to test the compound more generally to determine its efficacy and to see if cruciferous vegetables actually do inhibit the development of bladder cancer cells.

Screening for potential therapeutics in rodent models of AD has generally relied on testing compounds before pathology is present, thereby modeling disease prevention rather than disease modification.

Additionally, compared to many other test compounds we've previously tried for treating lupus, this one appears to be much more effective.»

Peter T. H. Wong and colleagues then tested the compounds in rats.

University of Chicago Medicine researchers have built a model system that uses multiple cell types from patients to rapidly test compounds that could block the early steps in ovarian cancer metastasis.

Finally, the researchers also tested the compound in mice that had been genetically modified to replicate the response of human iNKT cells.

Zymeworks would use its knowledge of computing to develop and license platforms: the software engines with which other companies could test their compounds virtually so as to stand a better chance of success in the laboratory.

Disney and his team tested their compound, called Targapremir - 18a, and found that it could target microRNA - 18a and trigger prostate cancer cell death.

Upon testing these compounds, they found that a number of them worked well in repelling a variety of flies such as D. melanogaster, D. yakuba, D. suzukii, D. pseudoobscura and D. virilis.

«We're going to start testing compounds immediately.

During testing with purified test compounds and real - world salmon and beef samples, the nose was selective and sensitive for cadaverine, even at low levels.

Another experiment in the study directly tested the compound's effect on the synaptic signal, the strength of the electrical connection between brain cells.

The experimenters successfully tested the compound in the two mouse models «either treating right at the beginning of diabetes, or for reversal of toxic effects after three or four months of diabetes, which is even more difficult,» King says.

Research Diets will incorporate test compounds into pelleted micro batches as small as 500 grams for those compounds that are in limited supply.

Feeding test compounds eliminates dosing related stress to the animal, eliminates vehicle effects, and saves time and labor.

Akhan Semiconductor has pushed back the release of its Mirage Diamond Glass, saying that it is actively testing the compound and that the first consumer devices sporting the improved diamond layer are slated to be made available in 2019.

Precise, graded addition of test compounds to your specified control diet allows evaluation of dose - response effects in your animal model.

The researchers collected samples of indoor dust from 11 homes in North Carolina and tested extracts from the samples in a mouse pre-adipocyte cell model, 3T3 - L1 cells, often used to test compounds for potential effects on the accumulation of triglycerides, a type of fat.

The researchers will then test their compounds in animal models to confirm that, upon chronic dosing, they are well tolerated and effectively lower tau levels in the brain.

The researchers also plan to test the compound in mice modeling Parkinson's disease.

Kelly M. Standifer, professor and chair of pharmaceutical sciences at the University of Oklahoma, points out that the researchers tested the compounds» potency in nonneuronal cells forced to express the receptors.

An independent lab study seen by CNBC suggests the tested compound had slightly less L - Tyrosine than SPRINT, which Woo confirmed.

Woo also said the tested compound had more Vitamin B12, but the lab test did not show this difference.

We test compound feeds that are to be labelled with the organic input Bud and pass them on to Bio Suisse for licensing.

We found at least one of five tested compounds (acetamiprid, clothianidin, imidacloprid, thiacloprid, and thiamethoxam) in 75 % of all samples, 45 % of samples contained two or more of these compounds, and 10 % contained four or five.

In their latest study, they tested compounds against cells from nine different types of human cancer, including common types affecting blood, colon, breast, prostate, ovaries, kidneys, and lungs.

Of the tested compounds, the most potent in terms of blocking androgens was the insecticide fenitrothion, an organophosphate insecticide used on orchard fruits, grains, rice, vegetables and other crops.

Schmidt says, «These people can test compounds or antibodies in well - defined animal models that are representative of a human disease.»

Identification of the master regulator genes will allow investigators to test compounds that interrupt their action, creating treatments that stop periodontal disease at its source.

«We hope to test this compound in clinical trials,» Ji said.

As intended, that change improved the test compounds» stability, meaning they would last longer in the body.

For example, the researchers are gaining a better understanding of how tweaks to the chemical structure of their test compounds affect the substances» cellular interactions in the body.

One of those tweaks added a polar group to the molecule, which made the test compounds more soluble.

For instance, one of the company's test compounds is good at inhibiting fertility but isn't very soluble, so it can't be taken by mouth.

9 The artificial sweeteners saccharin and aspartame were found accidentally when lab workers doing research that had nothing to do with sweetening put a bit of the test compounds in their mouths and liked what they tasted.

His head researcher had told him to test some compounds, but he misunderstood and tasted them instead.

A drug company is testing the compound to treat people with Down syndrome.

The Mayo team developed the patient - derived cell models to test the compounds in.

«We would like to be able to test these compounds in a clinical trial,» Xue says.

The test compounds (all from Sigma - Aldrich), ATP, 5 - HT, m - chlorophenylbiguanide (CPG), ondansetron (ODS), and 55 mm KCl (with KCl replacing equimolar NaCl) were added to HEPES buffer.

Then his team used a drug (not the test compound) to kill each mouse's liver before transplanting human liver cells into their bodies.

The tested compound looks and acts like the chemical building blocks of DNA, called nucleosides.

After a month on the test compound, the control animals with mouse livers seemed to do fine.