Sentences with phrase «test gene function»

Indeed, because eggs are large cells that are relatively easy to manipulate, they are one of the favored cell types used by biologists to express foreign genes and to test gene function.

Using genetic and epigenetic analyses coupled with powerful perturbation technologies to test gene functions in human cells and mouse models, we hope to identify the critical drivers of this disease and the basis for therapeutic responses.

Not exact matches

When the authors tested the ability of the lizard and snake versions of this limb - genital enhancer to function in mice, they found that the lizard version was capable of driving gene expression in the legs and the genitalia (much like the mouse version), while the snake version was only capable of driving gene expression in the genitalia.

Video of Adam, which can originate hypotheses about yeast genes and their functions, design experiments to test the ideas and conduct the work.

To test the hypothesis, sperm RNA elements corresponding to specific genes were characterized as a function of disease association.

For his part, Collins, who has led NIH since 2009 and been kept on by the Trump administration, pointed to an array of promising NIH activities, including the development of new technologies to provide insights into human brain circuitry and function through the Brain Research through Advancing Innovative Neuroethologies (BRAIN initiative) and the use of the gene - editing tool CRISPR - Cas9 to correct mutations and clear the way to develop and test a «curative therapy» for the first molecular disease: sickle cell disease.

Two projects will be done jointly with the Karolinska Institute in Stockholm: Molecular biologist David Baillie of Simon Fraser University in Burnaby, British Columbia, was awarded $ 6.73 million to study protein function in the soil nematode Caenorhabditis elegans, and microbiologist Sherif Abou Elela of the University of Sherbrooke, Quebec, received $ 3.75 million to test modified nucleic acid technologies for determining gene function.

According to Abouheif, Khila didn't just show that this new gene makes the water striders» fan; he also «reconstructs its evolutionary history, and then does the trademark ecological tests to show that it has an ecological function.»

Mice lacking the cryptochrome 2 blue - light photoreceptor gene (mCry2) were tested for circadian clock - related functions.

Researchers plan to test the function of these genes in future space station experiments.

Just like we test hypotheses about the functions of genes in genetic networks by knocking them out and replacing them, we need methods to selectively remove or inhibit specific microbes or metabolisms in microbial networks to determine their roles,» Brodie added.

Snyder - Mackler and colleagues first placed monkeys into groups of five and observed the social hierarchy they established, while conducting tests on gene expression and immune system function.

From there, scientists will study the expression of Woolly Mammoth mutations to test predictions about gene function.

Genes were filtered to have at least 5 reads per million mapped reads in at least 10 % of the samples on one of the tested groups (cpm function).

The microbe is particularly well suited for testing the functions of individual plant genes because bacterial DNA disrupts the genome at the point of insertion.

Genetic testing also can reveal many that have unknown consequences for the function of these genes, so their influence on cancer risk can't be predicted.

Test each mutant mouse line (4,000 mouse lines in the first 5 years, and ultimately up to 20,000) through a broad based primary phenotyping pipeline in all the major adult organ systems and most areas of major human diseases.Through this activity and employing data annotation tools, systematically aim to discover and ascribe biological function to each gene, driving new ideas and underpinning future research into biological systems.

Excluding genes with homology evidence for immune function, 42.24 % of induced genes encode proteins with bioinformatic evidence for a signal peptide, a significantly higher fraction that the 15.95 % of non-induced and non-immune genes that encode a protein with bioinformatic evidence for a signal peptide (P = 3.4 × 10 − 15, Fisher's Exact Test).

Although they rely on certain assumptions, such as the ability to define which variants truly affect gene function, aggregation tests have another thing going for them.

Fisher's exact test as implemented in R66 was run to test for enrichment or depletion of numbers of gene families for each molecular function category in the novel versus ancestral gene sets.

To test a possible homology of these cells with the chordamesoderm, we chose a chordamesoderm - specific gene set according to the following criteria: (i) specificity — their combined expression uniquely defines the chordamesoderm; (ii) conservation — their chordamesoderm expression is conserved in at least three of four vertebrate species; and (iii) function — they have proven essential for chordamesoderm development or signaling.

We are also examining how gene expression and mitochondrial function is altered in human cells in the disorder known as Chronic Fatigue Syndrome or Myalgic Encephalomyelitis, in order to develop objective tests for the illness as well to identify causal factors.

To address this challenge, the International Mouse Phenotyping Consortium is creating a genome - and phenome - wide catalog of gene function by characterizing new knockout - mouse strains across diverse biological systems through a broad set of standardized phenotyping tests.

In this method, all the genes are ranked according to the differential expression between two classes, and the Kolmogorov - Smirnoff test is used to determine the statistical correlation of the ranked gene list to the gene set of a given biological process, pathway or molecular function.

To that end, Berkeley Lab researchers will use CRISPR / Cas9 gene - editing technology, which Berkeley Lab scientist Jennifer Doudna helped pioneer, to systematically test the function of representative sequences in mice.

«With this technology, you can test the function of these candidate genes and measure what percentage of cells are generating into our target arterial cells,» says Zhang.

The test also includes a 50 + page report that really goes in - depth and gives feedback on your personal gene function and how to enhance your own gene expression.

The WellnessFX Cardiovascular Healthy Heart Genetic Test offers a comprehensive look at hundreds of genes related to cardiovascular health, including genes related to blood pressure, cholesterol, inflammation, and cardiovascular function.

This approach and the threshold of 0.2 allows us to test our hypothesis that T cell DNA methylation is associated with aggression trajectory and to generate further hypotheses about the functions of genes affected by the associated methylation changes.