Sentences with phrase «test in mice»

They then tested them in a mouse model of psoriasis, applying the compounds in a one percent skin cream for 28 days.

When tested in mice, the researchers did not observe any signs of addictive behavior.

Tests in mice showed, as hoped, that the wound chambers prevented inflammation.

First tested in mice, the vaccine's purpose is to encourage the animals to make disease - fighting antibodies to attack a tumor.

When tested in mice, it also improved the quality and strength of healing.

In tests in a mouse model of advanced atherosclerosis, core - shell nanoparticles, composed of block copolymers and targeted to sites of inflammation and vascular injury, delivered a bioactive peptide that improved key properties of advanced plaques.

In tests in mice with a very aggressive form of melanoma, the researchers found they could stop tumor growth by delivering this engineered form of IL - 2, along with antibody drugs, once a week.

The cells have been successfully tested in mice with a form of leukaemia, the team will tell a meeting of the American Society of Hematology in December.

These powerful ASOs are identified by the Krainer team as viable for testing in mouse models — the next step in the process of developing new human therapies.

Gould and his colleagues used a battery of behavioural tests in mice to show that one of ketamine's breakdown products — a compound called (2R, 6 R)- hydroxynorketamine — is responsible for much of the drug's antidepressant effects.

Rich and colleagues are now testing in mice whether combining Zika with traditional cancer treatments such as chemotherapy is more effective than either treatment by itself.

These two drugs were then tested in mouse models of two neurodegenerative diseases — prion disease (mad cow) and frontotemporal dementia — the same mice in which GSK2606414 had looked good in 2013.

Clinicians from the Bambino Gesu paediatric hospital's neurosciences department said tests in mice and patients with a similar, but not the same, genetic condition as Charlie had shown «dramatic clinical improvements».

Thinking that high concentrations of the corrosive NO might play a role in the nerve damage, Hilary Koprowski and his colleagues at Thomas Jefferson University in Philadelphia tested in mice three compounds — uric acid, PTIO, and D609 — that are known to scavenge NO or inhibit its production.

«Other antidepressants tested in mice, like fluoxetine, can take three weeks to show similar results on the same test.»

Brudno et al. designed a drug - delivery device that can be refilled noninvasively and tested it in a mouse tumor model.

In past tests in mice, the researchers have uncovered no toxic side effects from the gold used in the treatment, and have found no observable damage to healthy tissue from the low - energy laser.

«In pigs, the pattern of neurodegeneration is almost the same as in humans, and there have been several treatments tested in mouse models that didn't translate to human.»

While the 3D injectable scaffold is being tested in mice as a potential cancer vaccine, any combination of different antigens and drugs could be loaded into the scaffold, meaning it could also be used to treat infectious diseases that may be resistant to conventional treatments.

ZIKA BLOCKER A new therapy tested in mice curtails the effects of Zika virus (shown red in this transmission electron microscope image).

«Fire ant venom compounds may lead to skin treatments: Solenopsin analogs tested in mouse model of psoriasis.»

To discover if APECED patients» autoantibodies could have therapeutic potential, the team tested them in a mouse model of psoriasis, an autoimmune condition that causes red, itchy and scaly skin.

In preclinical tests in mice, a team at CSHL was able to dramatically change the character of an aggressive, metastatic primary breast tumor by targeting a single long non-coding RNA called Malat1 with a candidate drug called an antisense oligonucleotide (ASO).

But a new technique tested in mice and rats might provide a tool to combat the lethal tumors, known as glioblastomas.

Doctoral student Steve Stegen tested in mice how he could better equip the bone cells for that crucial stage between implantation and ingrowth of the blood vessels.

While the UC Riverside did not look at the toxicity of GO in their study, researchers at the Hersam group from Northwestern University did report in a paper published in the journal Nano Letters («Minimizing Oxidation and Stable Nanoscale Dispersion Improves the Biocompatibility of Graphene in the Lung») that GO was the most toxic form of graphene - based materials that were tested in mice lungs.

The findings, based on testing in mice, will appear this week in the Early Edition of the Proceedings of the National Academy of Sciences.

The final chemical, PZM21, was tested in mouse experiments and proved more potent than morphine, lasted longer and didn't produce the constipation and depressed respiration that morphine does.

Caldarone, B. J.; Wang, D.; Paterson, N. E.; Manzano, M.; Fedolak, A.; Cavino, K.; Kwan, M.; Hanania, T.; Chellappan, S. K.; Kozikowski, A. P.; Olivier, B.; Picciotto, M. R.; Ghavami, A. Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5 - I - A85380.

Paterson, N. E.; Iwunze, M.; Davis, S. F.; Malekiani, S. A.; Hanania, T. Comparison of the predictive validity of the mirror chamber and elevated plus maze tests in mice.

In the study, Kwong's team successfully put their remote - control method through initial tests in mice with implanted tumors (so - called tumor phantoms, specially designed for certain experiments).

They should test in mice delayed or prevented sexual maturation to see the effect it has on life spans.

Schenk also revealed some very early information specific to PRX002, the humanized version of the most promising antibody tested in the mouse studies, which was then slated to enter into early - stage human trials.

The discovery of the molecule and the results of the subsequent memory tests in mice were published in eLife, an online scientific open - access journal, on May 28.

Working in collaboration with LJI Alessandro Sette, he has now identified several peptides suitable for vaccinating humans and will test those in mice engineered to harbor a humanized immune system.

You can send it to us via our Facebook page or through the contact form on... Continue reading Research Roundup: Cancer vaccine tested in mice goes to clinical trials, e-cigarette smoke found to damage DNA and more.

Like Zika, West Nile can harm a fetus, tests in mice show.

Details of the therapy, which was successfully tested in mice, were published online in the Journal of Investigative Dermatology.

In their previous study, the researchers found that drugs that inhibit FGFR3 kinase, an enzyme that helps the protein produced by this fusion gene do its work, increased survival when tested in mice with glioblastoma.

The simulated results provide information that can help design miniature versions of the implants for testing in mice, where researchers hope to gain a preliminary measure of how well such devices may restore vision to humans.

Guichard and her colleagues further identified several molecular inhibitors critical to mediating these effects and tested them in mice with positive results.

Although human studies have linked these abnormalities with attention deficits, Noebels and his team did not specifically perform any behavioural tests in the mice.

Suvorov wanted to test in mice whether pollutants might cause or intensify behaviors typical of autism or ADHD.

Instead, they create a library of several hundred fluorophores with varying chemical additions and three - dimensional conformations and then test each in mice to see which are taken up by specific tissues in the body.

So far, they have designed vaccines against Ebola, H1N1 influenza, and Toxoplasma gondii (a relative of the parasite that causes malaria), which were 100 percent effective in tests in mice.

Stem cells that were engineered to have higher amounts of Miro1 were able to transfer mitochondria more efficiently and were therapeutically more effective when tested in mouse models of airway injury and asthma, compared to untreated cells.

Liver cells carry out hundreds of different functions, only some of which Lagasse has tested in mice, and it is unlikely that transplanted cells could fulfill all of them in humans.

«So far, the drug has only been tested in mice, and while some research in human genetics suggests this approach could work in people too, we need more research before we know how relevant this could be for people with type 2 diabetes.»

In tests in mice, the beads glowed through the animals» skin under ultraviolet light, varying in brightness as blood glucose levels changed.