Not exact matches
The focus of those hopes is the liquid biopsy: a
test that could detect and analyze a solid
tumor from biomarkers in the bloodstream or other easily
sampled body fluids, such as saliva.
In blood
samples from 1005 patients with eight types of
tumors that had evidently not yet metastasized, the
test detected between 33 % and 98 % of cases, depending on the
tumor type (see graph, above).
To that end, in collaboration with the University of Zurich and MD Anderson Cancer Center, the researchers
tested melanoma
tumor samples from human patients undergoing treatment with the same targeted therapies.
Using
tumor samples from a patient, they do lab
tests to determine which substances can first make the different types of cancer cells uniform and then effectively kill them.
The minimally invasive
test could reduce the need for the sometimes painful and risky procedures involved in
sampling tumors, particularly those that reside deep within the body.
By growing organoids from
tumor samples, researchers can create minitumors and use them to study how cancer develops or to
test drugs.
«We used biopsied
tumor samples from DIPG patients to create models in the lab, which we studied and then used to
test a novel, targeted approach to treating the
tumor.
«Being able to safely take tissue
samples will also allow us to
test for specific
tumor sub-types and better decide the most appropriate treatment for each individual patient,» added Dr Booton.
The role of rebiopsy and repeat analysis in the setting of post-treatment relapse, along with
testing of blood
samples for mutations in circulating
tumor cells, cell free
tumor DNA, or exosomes will be considered.
The researchers also employed
tumor - marker
testing by genotyping patient
samples to pinpoint
tumor mutations and
tumor type.
Searching for T cells that had infiltrated the
tumors, they collected as many as 50 T cell
samples from a single
tumor; next, the team
tested each batch of T cells against other
tumor samples from the same patient.
To
test their hunch, the researchers isolated microvesicles from 30 frozen
tumor samples and looked for mRNA from a particular growth receptor unique to glioblastomas.
In order to
test whether the method is suitable for use in clinical routine diagnostics, the scientists analyzed more than 1,100 additional
tumor samples.
The
test, called ProsignaTM and manufactured by NanoString Technologies, comes with a machine and kit, so patients»
tumor samples do not have to be sent to a single laboratory for analysis.
Their theory was first confirmed with ovarian cancer cell lines and then the Peter / Lengyel team
tested HGMA2 protein levels in
tumor samples from 100 patients with ovarian cancer.
In close collaboration with oncologists at the Olivia Newton John Cancer Research Institute (ONJCRI), the technology was
tested on blood
samples from melanoma patients and was able to track critical changes in spreading
tumor cells before, during and after treatment.
«The end game is to take the guesswork out of chemotherapy, with a clinical
test that will assess dozens of drugs and drug combinations against
tumor samples from each patient.»
Laser Light
Test Reveals Spreading Cancer Cancer imaging and breast cancer experts used advanced microscopes equipped with tissue - penetrating laser light to develop a promising new way to accurately analyze the distinctive patterns of ultra-thin collagen fibers in breast
tumor tissue
samples and to help tell if the cancer has spread.
When the researchers compared average cytokine levels in CFS patients versus the healthy control
samples, they found that only 2 of the 51 substances they
tested for were significantly different: One, called
tumor growth factor beta, was higher in CFS patients, while the other, called resistin, was lower.
By performing
tumor sample testing we can determine what type of breast cancer it is, and what subtypes of breast cancer are relevant to the case.
To make a diagnosis for the canine eye
tumors mentioned, your veterinarian will want to take a small
sample of the
tumor for
testing in a lab.
Finally, Hannibal's
tumor sample made it to Breen's lab at NC State, where a genomic
test and pathology report confirmed a diagnosis of T cell lymphoma.
Cytology (the microscopic examination of cell
samples drawn from the
tumor using a needle and syringe) is sometimes helpful as a rapid or preliminary
test.
Due to advances in veterinary medicine,
tests can be applied to mast cell
tumor biopsy
samples to determine if certain chemotherapeutic agents should be used for treatment.
Accession high volume of solid
tumor, and wet
samples for The Department of Diagnostic Molecular Pathology Train / Mentor new hires to efficiently process laboratories
samples, and transcribe clinical reports Process received Molecular orders to respective specialties within the Department of Pathology to review, and submit adequate material Actively assist in workflow modifications, and training manuals Transcribe clinical reports for all molecular
tests in a timely manner Actively follow up with office assistants and clinicians within the institution to ensure proper paperwork / specimens are submitted for IMPACT
testing.